ABSTRACT
The article deals with the influence of dust load on coal miners' health state, the quality characteristics of mine dusts and degrees of coniotic changes in the lungs affected as a result of the nervous elements' reactions. Described are the peculiarities of the chronic processes in the nervous system in mine workers affected with dusts.
Subject(s)
Air Pollutants, Occupational/adverse effects , Anthracosilicosis/pathology , Coal Mining , Lung/innervation , Neurons/pathology , Anthracosilicosis/etiology , Atrophy , Dust/adverse effects , Humans , Necrosis , UkraineABSTRACT
A study was performed on white rats of the physiological, biochemical, haematological and pathomorphological indices in separate and combined actions of formaldehyde (FA) (60.0 +/- 12.7 mg/m3 in one-time exposition and 7.2 +/- 1.2 mg/m3 in a 30-day long experiment) with a concomitant increased barometric pressure (IBP) characteristic of deep coal mines (111 and 123 kPa corresponding to 1000 and 2000 m deep mines respectively). It was established that, at 123 kPa, lipoid peroxide oxidation process was stimulated in combination with microcirculatory disorders, growing FA concentration in the serum and pulmanary tissues. The shifts were still more vivid at growing IBP.
Subject(s)
Atmospheric Pressure , Formaldehyde/toxicity , Animals , Coal Mining , Formaldehyde/analysis , Formaldehyde/blood , Lipid Peroxidation , Lung/chemistry , Male , Rats , Time FactorsSubject(s)
Coal Mining , Lung , Pneumoconiosis , Humans , Lung/diagnostic imaging , Lung/pathology , Middle Aged , Pneumoconiosis/diagnostic imaging , Pneumoconiosis/pathology , RadiographySubject(s)
Coal Mining , Pneumoconiosis/epidemiology , Algorithms , Humans , Pneumoconiosis/diagnosis , Prognosis , Risk , UkraineSubject(s)
Anthracosilicosis/therapy , Bronchitis/therapy , Coal Mining , Hyperbaric Oxygenation , Adult , Animals , Dust/adverse effects , Humans , Male , Middle Aged , RatsSubject(s)
Lung/enzymology , Oxidoreductases/metabolism , Silicosis/enzymology , Animals , Dust/adverse effects , Lung/pathology , Male , Rats , Rats, Inbred Strains , Silicosis/pathologyABSTRACT
A Soviet low-molecular weight polymeric preparation polyvinylpyridine-N-oxide in doses producing a marked antisilicotic effect (1 g/kg bw, 5 injections for 2 weeks or inhalations at a concentration of 57.9 +/- 4.11 mg/m3 for one hour a day 5 times a week over 8 months or throughout the entire pregnancy) does not affect generative function of rats or mice and progeny of two generations.