[Dynamics of EKG changes in patients with Itsenko-Cushing disease before surgery, and following the 1st and 2d stages of adrenalectomy]. / Dinamika izmenenii EKG u bol'nykh bolezn'iu Itsenko--Kushinga do operatsii, posle pervogo i vtorogo étapov adrenaléktomii.

The results of examination of ECG in 44 patients suffering from Itsenko-Cushing's disease at different stages of surgical treatment are presented. The data obtained were compared with the blood potassium and sodium levels, 17-KS, and 17-OCS levels in the urine, arterial pressure and cholesterol content. Various ECG changes before the operation were revealed in 39 patients. Signs of enlargement of the left ventricle and deformity of the end part of the ventricular complex (negative T wave and or reduction of S-T segment in I, II, avL V5-6 leads) were found in 8 patients, and deformity of the end part of the ventricular complex without any signs of enlargement of the left ventricle--in 18 patients. There proved to be a significant dependence of the changes in the end port of the ventricular complex on increased urinary excretion of 17-OCS, hypokaliemia and hypernatriemia. Negative ECG changes after bilateral total adrenalectomy was significantly connected with postoperative hypocorticism.

[Dynamics of changes in the indicators of electrolyte metabolism after surgical treatment of Cushing's syndrome]. / Dinamika izmenenii pokazatelei elektrolitnogo obmena posle khirurgicheskogo lecheniia bol'nykh bolezn'iu Ishchenko-Kushinga

The authors present the results of study of the state of the water-electrolyte metabolism at the early postoperative period in 58 patients suffering from Itsenko-Cushing's disease with consideration of the potassium deficiency correction. Potassium and sodium level was studied in the plasma and the erythrocytes. Besides, in 31 patients potassium and sodium content were examined in the muscular tissue obtained during the operation. Hypoglycemia was revealed in 48.2% of the cases, and hypernatriemia--in 19.0%. A reduction of potassium level in the erythrocytes was revealed in 50%, and a rise of sodium--in 52% of cases. The muscle tissue potassium level fell in parallel to the reduction of this electrolyte level in the erythrocytes. Disturbances of the electrolyte balance proved to be most pronounced at the early postoperative period in the patients given no potassium preparations. Separate use of potassium preparations, or (particularly) together with veroshpiron, prevented potassium deficiency at the early postoperative period.