ABSTRACT
DNA distribution was studied in tumor cells of 54 patients with bladder cancer. Diploid and aneuploid distributions were recorded in 34 and 20 cases, respectively. Aneuploid DNA proved to be a negative prognostic factor as 5-year survival of such patients made up 48.2%, the lethality rate being 1.78 (p = 0.04). For diploid tumors the above parameters were 80.7% and 0.63, respectively. Poor differentiation of the tumor, invasion in lamina propria, lymphatic and blood vessels occurred much more frequently in patients with aneuploid tumors which appeared to indicate high-grade malignant potential of such tumors. It is concluded that DNA content in bladder cancer is a valuable prognostic criterium. This biological marker requires further studies.
Subject(s)
Carcinoma/mortality , Urinary Bladder Neoplasms/mortality , Aneuploidy , Biopsy , Carcinoma/chemistry , Carcinoma/pathology , DNA, Neoplasm/analysis , Diploidy , Female , Humans , Male , Prognosis , Urinary Bladder/pathology , Urinary Bladder Neoplasms/chemistry , Urinary Bladder Neoplasms/pathologyABSTRACT
DNA quantitation by flow cytometry was made in 36 patients with morphologically diagnosed prostatic cancer (PC) in stage II, III and IV (4, 14 and 18 patients, respectively). All the patients received adequate treatment. Aneuploid tumours were found in 25 patients (group 1), diploid ones in 11 patients (group 2). A 3-year survival in group 1 made up 65.5%, in group 2 all the patients survived 3 years. The recurrence-free survival was 22.2% and 78.8%, respectively. The above findings make it possible to regard flow cytometry DNA estimation as a reliable prognostic indication in PC.
