ABSTRACT
The authors studied the activity of a pathological process in the lymph nodes of the mediastinum, by using 67Ga citrate and 99mTc, and pulmonary circulation with MAA-99mTc. Radionuclide studies have established that in new cases of respiratory tuberculosis, the function of lymph nodes recovers by 1.5 times higher than that in pretreated patients. In patients with destructive tuberculosis, pulmonary circulation restores insignificantly and slowly, particularly in a group of pretreated patients. This is explained by the fact that the lung fibrous changes available prior to therapy defy an evolutionary process.
Subject(s)
Lymph Nodes/diagnostic imaging , Tuberculosis, Pulmonary/diagnostic imaging , Citrates/pharmacokinetics , Gallium/pharmacokinetics , Humans , Lung/blood supply , Lung/diagnostic imaging , Lung/pathology , Lymph Nodes/pathology , Microcirculation , Mycobacterium tuberculosis/isolation & purification , Radionuclide Angiography/methods , Radiopharmaceuticals/pharmacokinetics , Technetium/pharmacokinetics , Tuberculosis, Pulmonary/microbiology , Tuberculosis, Pulmonary/pathologySubject(s)
Tuberculosis, Pulmonary/diagnostic imaging , Tuberculosis, Pulmonary/pathology , Humans , Inflammation/diagnostic imaging , Inflammation/pathology , Lung/diagnostic imaging , Lung/pathology , Lung/physiopathology , Pulmonary Circulation , Pulmonary Ventilation/physiology , Radionuclide Imaging , Technetium , Tuberculosis, Pulmonary/physiopathologyABSTRACT
Studies of the time course of changes in regional blood flow and regional ventilation of the lung in patients with destructive pulmonary tuberculosis (DPT) suggest that there may be different shifts in radionuclide indices after antibacterial therapy. Full recovery of regional blood flow and regional ventilation of the lung sometimes is accounted for by the resolution of inflammatory changes, by the healing of destruction frequently attended by a significant improvement, but there is a more regular change in the areas of the underlying process in particular, through evolving pneumosclerosis. A comprehensive radionuclide study in patients with destructive pulmonary tuberculosis in combination with clinical and X-ray studies allows clinicians to investigate the extent and site of a pathological process and thereby to define the functional status of capillary blood flow and pulmonary alveoles. Radionuclide studies enable a trend of a pathological process in the lung to be defined during treatment since alterations in the lung reflect the time course of changes in a specific process and the efficiency of treatment.
