[The leading role of mitochondrial depolarization in the mechanism of glutamate-induced disorder in Ca(2+)-homeostasis]. / Vedushchaia rol' mitokhondrial'noi depoliarizatsii v mekhanizme glutamat-vyzvannogo narusheniia Ca(2+)-gomeostaza.

Digital fluorescence imaging techniques were employed to monitor changes in the cytoplasmic Ca2+ concentration and mitochondrial potential in fura-2 AM or rhodamine-123 loaded individual cerebellar granule cells during and following the Glu exposure. The data obtained suggests that the MD-induced blockade of the mitochondrial Ca2+ uptake and a reversal of the mitochondrial ATP-synthase play a critical role in the mechanism of the glutamate-induced disorder of neuronal Ca2+ homeostasis.