[Lines of research in the field of cellular technologies and its application in military medicine].

The paper presents an overview of cellular therapy products and medical tissue engineering of the leading countries of the world (including the US) and identifies lines of research in the field of cellular technology application in the interests of national military medicine. The authors gave information concerning practical implementation of the achievements of biomedical research in the field of regenerative cellular products and technologies in Russia as different products, which may be used at the stages of medical evacuation. The authors presented results of research, which was, performed on the model of mine blast injury in accordance with principle possibility of the usage of cellular technologies products (multipotent mesenchymal stromal cells) in medical practice.

[Clinical and experimental investigation on the radioprotective effect of riboxine in low-dose fractionated irradiation]. / Kliniko-éksperimentalnoe issledovanie radiozashchitnoi éffectivnosti riboksina pri fraktsionirovannom obluchenii v malykh dozakh.

In experiments with dogs (fractionated y-irradiation, accumulated dose 1Gy) as well as in clinical testing of the group of men, recieved 0,25 Gy being engaged in the Chernobyl NPS disaster repairment, the positive influence of riboxin (purine nucleoside) course treatment on parameters of peripheral blood and non-specific resistance system has bee n shown.

[Study of the combined action of an antibiotic and an immunostimulator using mathematical modeling]. / Izuchenie kombinirovannogo deistviia antibiotika i immunostimuliatora metodom matematicheskogo modelirovaniia.

A mathematical model of antibiotic and immunostimulator (IMS) combined effect on various elements of the immune system and general state of patients with infectious diseases is described. The model was constructed as a system including 6 usual differential equations of the 1st order. With the use of this model and a computer many diverse variants of infection development under conditions of treatment with IMS at the background of antibiotic therapy were modeled. Ii was shown that IMS-antibiotic complexes markedly improved the indices of antibiotic therapy as compared to the use of the antibiotics alone. In combined use of IMS and antibiotics it was possible to lower the antibiotic doses without lowering the antimicrobial effect. The use of IMS at the optimal period led to balanced activation of the host specific and nonspecific resistance factors at the background of antibacterial therapy. The results of the mathematical modeling corresponded to the data on protective effect of salmozan (IMS) and doxycycline (antibiotic) combination in animals (albino mice). It was concluded that the described mathematical model was adequate for validation and optimization of schemes for combined use of IMS and antibacterial agents.

[Comparative evaluation of the effect of immunostimulants on the dehydrogenase activity of the mouse thymus]. / Sravnitel'naia otsenka vliianiia immunostimuliatorov na aktivnost' nekotorykh degidrogenaz timusa myshei.

Comparative biochemical estimation of the influence of yeast RNA, prodigiosan and levamisole on the activity of lactate dehydrogenase, malate dehydrogenase and glutamate dehydrogenase in the thymus of mice was carried out. It was shown that the immunostimulants induced different qualitative and quantitative changes in the activity of the enzymes. Administration of yeast RNA resulted in activation of lactate dehydrogenase, malate dehydrogenase and glutamate dehydrogenase. Prodigiosan increased the activity of lactate dehydrogenase and glutamate dehydrogenase but not that of malate dehydrogenase. The action of levamisole was characterized by long-term activation of glutamate dehydrogenase. The possible mechanisms of the influence of these drugs on the metabolic activity of the thymus are discussed.