ABSTRACT
New medicinal plant preparations of polyphenol nature, representing the derivatives of bioflavonoids (piflamin) and ellagotannins (altan and ellagic acid) were experimentally studied. The drugs exhibited antioxidant properties, which were manifested by inhibition of a pathological lipid peroxidation, restoration of the functional activity of the antioxidant system components, and stabilization of the hepatocyte membranes.
Subject(s)
Antioxidants/pharmacology , Ellagic Acid/pharmacology , Flavonoids/pharmacology , Tannins/pharmacology , Animals , Carbon Tetrachloride Poisoning/metabolism , Cell Membrane , Chemical and Drug Induced Liver Injury/metabolism , Female , Hepatocytes/drug effects , Hepatocytes/ultrastructure , Lipid Peroxidation/drug effects , Liver/drug effects , Liver/metabolism , Liver/ultrastructure , Male , Mice , RatsABSTRACT
The article presents the material on the study of the cardioprotective effect of ellagic acid on a model of neoepinephrine myocarditis in rats. In doses of 0.5-1 mg/kg ellagic acid causes a marked antioxidant effect. Restores the disturbed myocardial functions. The reference-agent vitamin E (50 mg/kg) yields to ellagic acid as a cardioprotector. The effect of 0.5 mg/kg of ellagic acid was more stable than that of a 1 mg/kg dose. The cardioprotective activity of the drugs under study was determined according to the POL parameters in a myocardial homogenate and blood serum and according to the EEG parameters and the degree of cardiomyocyte cytolysis.
