[Rosuvastatin in prevention of cardiac complications following surgical treatment of patients with vascular pathology].

The article deals with the findings of studying the use of rosuvastatin in patients after endured reconstructive operations on the brachiocephalic arteries and aortofemoral segment in order to prevent cardiac atherothrombotic complications. A total of thirty patients were given "Crestors" at a daily dose of 10 mg for two weeks prior to surgery and for two weeks postoperatively and were found to have a significant decrease in the average levels of total cholesterol and low-density lipoproteins, which was accompanied and followed by certain improvement in the functional state of the vascular wall, with no cardiac complications being observed in either case.

[Liprimar in prevention of coronary complications in patients following reconstructive vascular surgery].

The article is dedicated to analyzing the outcomes of an open prospective study of efficacy of Liprimai administered in the postoperative period. The study comprised a total of 30 patients presenting with atherosclerotic lesions of the arteries of the carotid bed and aorto-femoral segment, who were subjected to reconstructive vascular operations. The aim of the present study was to look into a possibility of preventing cardiac complications in patients after endured reconstructive vascular surgery. Liprimar was administered at a daily dose of 10 mg seven days prior to the operation, and for eight days thereafter.

[Administration of Gadobutrol in coronary artery stenting in a female patient with allergy to iodine-containing radiopaque agents].

Presented herein is a case report of a successful treatment of subtotal stenosis of the anterior interventricular artery (over 95%) using paramagnetic contrast agent Gadovist 1.0 in a female patient with a polyvalent allergy, including that to iodine-containing radiopaque substances. Immunological tests for drug intolerance according to the Demyanenko technique using Gadovist 1.0 were followed by coronography and stenting of the anterior interventricular artery. The immediate outcomes were assessed as good: the lumen of the anterior interventricular artery was restored completely, with sufficient filling in of the distal portions of the artery. The total volume of the administered contrast substance amounted to 1.8 ml/kg. No alterations in the markers of the renal function were noted. This case report demonstrates a possibility of using contrast medium Gadovist 1.0 as a radiopaque substance in an endovascular intervention, also confirming that Gadobutrol exerts no side effect on the kidneys, even if administered in high doses.

[Estimation of the protective effect of Nebilet for perioperative cardiac complications in patients underwent vascular surgery: results of prospective study].

We report results of our prospective study - administration of Nebilet in 30 patients in perioperative period. Aim of this study is to estimate the protective effect of Nebilet for perioperative cardiac complications (nonfatal myocardial infarction and cardiac death) in patients which underwent recostructive vascular surgery. Patients were administrated Nebilet (2.5 to 7.5 mg/per day, according to arterial pressure and heart rates) 20 days before operation and 2 months after surgery. In early postoperative period we performed the control examinations: troponin T (1, 3, 7 days), ECG (1 day), echocardiography (1-2 day) and 2 months after operation (ECG and echocardiography). During whole follow up period we controlled in patients arterial pressure and heart rates.

[Substantiation and varieties of complex surgical treatment tactics for pyo-necrotic forms of diabetic foot]. / Obosnovanie i varianty taktiki kompleksnogo khirurgicheskogo lecheniia gnoino-nekroticheskikh form "diabeticheskoi stopy".

For the period from 1996 to 1998 in the Division of wounds and wound infection of A.V. Vishnevsky Institute of Surgery 92 patients with pyonecrotic forms of "diabetic foot" underwent thorough examination and treatment. The patients were divided into groups by the form of "diabetic foot": with pyonecrotic forms of "diabetic foot" without critical ischemia (group 1) and with it (group 2). In 18 patients of both groups the data of electron autoradiography were used to reveal peculiarities of the wound process. Group 1 patients had at admittance a large number of neutrophiles in various stages of destruction in biopsies of the wound. In patients of group 2 a great majority of the vessels in biopsies of the wound were in different stages of destruction with lost connections between their separate cells or some of their part absent. Separate cells (endotheliocytes and pericytes) which make up the walls of destroying vessels, were synthesizing RNA and were functionally active. In both groups, the studied parts of the wound before plastic repair of its defect usually represented as well developed granulation tissues with a number of microvessels and cells. Intensive synthesis of PNA in the cells of microvascular wall evidenced of their high functional activity, and the synthesis of DNA in them showed their ability for proliferation, i.g.--for growth. Thus, microangiopathy was reversible, and the solution of the problem of critical ischemia should be considered in the light of macroangiopathy. Thus, in patients of group 1 the cause of pyonecrotic damage consists in infection process, while in patients of group 2--in combination of infection with ischemia of the extremity. In both groups pyonecrotic disease of the extremity ruses at the background of severe disturbances of cellular immunity.