[Effect of cardiac glycosides on the calcium ion binding by biomembrane lipids]. / Vliianie serdechnykh glikozidov na sviazyvanie ionov kal'tsiia lipidami biomembran.

By using methods of fluorescent and spine (electron paramagnetic resonance) probes it was shown that cardiac glycosides (digoxin, digitoxin, convallatoxin, corelborine and strophanthin) effectively interact with biomembrane lipids enhancing conformational motility of lipids and cause additional binding of calcium ions with the membrane.

[Interaction of beta-adrenergic agents with the plasma membranes of the myocardium]. / Vzaimodeistvie beta-adrenergicheskikh sredstv s plazmaticheskimi membranami miokarda.

The initial stage of interaction of beta-adrenomimetics and beta-adrenoblockers with specific membrane binding sites is characterized by different patterns of thermodynamic parameters. Administration of isadrin results in a decrease of entropy and enthalpy, which reflects the primary binding reaction and agonist-specific receptor isomerization to the conformational form activating adenylate cyclase. Anaprilin and alpheprol do not change the receptor conformation and participate only in the primary binding reaction which is marked by a decrease in enthalpy and a rise of entropy in the course of interaction of beta-adrenoblockers with specific membrane binding sites. The different patterns of thermodynamic parameters under the effect of beta-adrenomimetics and beta-adrenoblockers on plasma membranes are explained by the different influence of these substances on the mobility of membrane lipids, i.e. on the viscosity of plasma membranes.

[Geno- and phenotypic distribution by the ABO and Rhesus systems in the population of Minsk]. / Geno- i fenotipicheskoe raspredelenie po sistemam ABO i rezus naseleniia g. Minska.

The distribution of blood groups of the ABO system is different in the rhesus-positive and rhesus-negative subpopulations. An increasing frequency of the phenotype A2 in the rhesus-negative subpopulation is observed. The calculation of the gene frequency reveals a deficiency of genes A1 and O, and the increasing frequency of genes A2 and B in the rhesus-negative part of the population. On the whole for the inhabitants of Minsk the ratio of the phenotypes A2/A1 differs significantly from the corresponding index for the republic as a whole, which is the evidence of a significant migration of the population in the capital of Byelorussia. The observed correlative dependences in the distribution of the genes of ABO system and of the rhesus system permit to recommend the accomplishment of a scientific search between the hereditary pathology and the susceptibility to different diseases and blood groups taking into consideration the rhesus appurtenance of the populations studied.

[Study of the microstructure of the water-protein layer of spin-labeled preparations of lysozyme by the magnetic relaxation method]. / Issledovanie mikrostruktury vodno-belkovogo sloia spin-mechenykh preparatov lizotsima metodom magnitnoi relaksatsii.

Possible applications of magnetic relaxation to the studies of microstructures of water-protein layer of spin-labelled proteins and enzymes are analyzed on lyzozymes taken as an example. It is shown that the effective time of correlation of dipole-dipole interaction of the complex spin label--water proton (Tauc), as well as thermodynamic parameters Eeff. and delta Seff. reflect the local state of solvatic surrounding of lyzozyme in case of long labels. Conformation transitions of lyzozyme are revealed at the change of temperature (5--80 degrees C) and as a result of binding of a specific inhibitor NAG. It is concluded that local physico-chemical properties of water-protein matrix of lyzozyme spin-labelled preparations depend on protein conformational state.