ABSTRACT
Typical ischemic damage to neurons were detected in the focus of experimental photothrombosis and in the transition zone. They were associated with symptoms of impaired motor functions and dysfunction of pelvic organs. The applied method of focal photothrombosis can be used for simulation of spinal cord ischemia for the development of methods for pharmacological correction and restoration of impaired sensorimotor functions.
Subject(s)
Neurons/pathology , Spinal Cord Ischemia/pathology , Spinal Cord/radiation effects , Thrombosis/pathology , Animals , Disease Models, Animal , Male , Motor Activity/radiation effects , Neurons/radiation effects , Neurons/ultrastructure , Rats , Rats, Wistar , Spinal Cord/pathology , Spinal Cord Ischemia/etiology , Thrombosis/etiology , Ultraviolet Rays/adverse effectsABSTRACT
This review is devoted to the control of hair growth. The hair follicle undergoes cyclic transformation from the resting phase (telogen) to the growth phase (anagen). The latter phase is characterized by rapid proliferation of follicular keratinocytes and elongation and thickening of the hair shaft. The regression phase (catagen) leads to the involution of the hair follicle. These cyclic changes include rapid remodeling of both the epithelial and the dermal components. They are controlled by numerous different factors: sex hormones, neurotrophins, FGF, TGF, BMP, VEGF, Sonic Hedgehog, and other signaling pathways.
