ABSTRACT
We demonstrate a versatile nanoparticle with imaging-guided chemo-photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo-photothermal synergistic therapy toward liver cancers in the near future.
Subject(s)
Antineoplastic Agents , Epithelial Cell Adhesion Molecule/metabolism , Fluorescent Dyes , Indoles , Polymers , Quantum Dots , Animals , Antibodies, Immobilized/chemistry , Antibodies, Immobilized/metabolism , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacokinetics , Antineoplastic Agents/pharmacology , Female , Fluorescent Dyes/chemistry , Fluorescent Dyes/pharmacokinetics , Fluorescent Dyes/pharmacology , HeLa Cells , Hep G2 Cells , Humans , Indoles/chemistry , Indoles/pharmacokinetics , Liver Neoplasms/metabolism , Mice , Mice, Inbred BALB C , Polymers/chemistry , Polymers/pharmacokinetics , Quantum Dots/chemistry , Quantum Dots/metabolism , Theranostic Nanomedicine/methodsABSTRACT
We report the bubble dragged microrocket consisting of functionalized multilayer polymer covered asymmetrically by platinum nanoparticles. The microrocket is pushed back during bubble growth over a small step and dragged forward over a big step during bubble explosion. Each bubble explosion induced a shock wave of gas which propagates in water at ultrafast speed. The bubble dragged microrocket can move along an approximate straight line instead of a fluctuating circle which is the trajectory of a bubble-pushed microrocket in most cases, which makes it a promising candidate for drug delivery and simulating rod-shaped bacteria.
