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Modification of biological activity of lipopolysaccharide in the complex with chitosan.
Ermak, I M; Davydova, V N; Gorbach, V I; Berdyshev, E L; Kuznetsova, T A; Ivanushko, I A; Gazha, A K; Smolina, T P; Zaporozhets, T S; Solov'eva, T F.
Bull Exp Biol Med ; 137(4): 379-81, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15452608

ABSTRACT

In the complex with chitosan, lipopolysaccharide partially lost its ability to induce lymphokines tumor necrosis factor and interleukin-8, but retained immunostimulating properties and increased phagocytic function of macrophages by improving digestion of bacteria.


Subject(s)
Chitosan/immunology , Lipopolysaccharides/immunology , Animals , Escherichia coli/metabolism , Interleukin-8/immunology , Macromolecular Substances , Macrophages, Peritoneal/immunology , Mice , Spleen/cytology , Spleen/immunology , Tumor Necrosis Factor-alpha/immunology , Yersinia pseudotuberculosis/metabolism
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