ABSTRACT
Levamisole is an immunomodulatory drug which can trigger development of levamisole-induced multifocal inflammatory leukoencephalopathy (LIMIL) in patients treated for helminthic invasion, aphthous stomatitis, cancer, or cocaine users. LIMIL clinical case in patient 45 years old after single dose of levamisole (taken without any medical prescription) was described. We presented clinical history and clinical picture, MRI and laboratory data and treatment results during 1-year observation. According to similarity of LIMIL with acute disseminating encephalomyelitis or debut of multiple sclerosis and high frequency of levamisole usage in Russia (usually without medical prescription) LIMIL should be included in differential diagnosis in demyelinating disorders and treated according to current clinical recommendation.
Subject(s)
Adjuvants, Immunologic/adverse effects , Demyelinating Diseases , Leukoencephalopathy, Progressive Multifocal/chemically induced , Levamisole/adverse effects , Adjuvants, Immunologic/therapeutic use , Humans , Levamisole/therapeutic use , Magnetic Resonance Imaging , Middle Aged , RussiaABSTRACT
We studied the dynamics of neurological deficit and parameters of the blood flow through middle cerebral arteries in 97 patients with acute ischemic stroke (IS). Absolute and relative parameters of the blood flow were compared to the severity of neurological deficit in the 1st, 5-7th and 21-23rd days. There was a strong correlation between the asymmetry in blood flow velocity in the first day of II and NIHSS scores in 21-23rd days (r= -0,96; p<0,01). The less pronounced asymmetry in the first day of IS predicted the better recovery of damaged functions in patients with IS.
Subject(s)
Brain Infarction/physiopathology , Carotid Artery Diseases/complications , Cerebrovascular Circulation/physiology , Middle Cerebral Artery/physiopathology , Aged , Blood Flow Velocity , Brain Infarction/diagnostic imaging , Brain Infarction/etiology , Carotid Artery Diseases/diagnosis , Carotid Artery Diseases/physiopathology , Female , Follow-Up Studies , Humans , Male , Middle Cerebral Artery/ultrastructure , Prognosis , Severity of Illness Index , Ultrasonography, Doppler, TranscranialABSTRACT
Specific feature of occupational medicine in highly aluminiferous mullitic refractories production nowadays is dust factor associated with disintegration, crushing and pressing of fireclays and coal clays. Therefore average shift dust levels increase and considerably exceed the MAC. Calcination process is associated with slightly exceeded MAC for sulphur dioxide and carbon dioxide and MAL for noise.
