ABSTRACT
Neoplasms of the epididymis are uncommon, and malignant tumors are extremely rare. We report a case of clear cell papillary cystadenocarcinoma of the epididymis presenting with a long history of painless scrotal mass on the left side. Immunohistochemical markers for clear cell renal cell carcinoma (RCC) were examined to distinguish between clear cell papillary cystadenocarcinoma of the epididymis and metastatic clear cell renal cell carcinoma. The present case was positive for cytokeratin-7, PAX2, vinculin, vimentin and carbonic anhydrase IX. Expression of CD10 was focally observed. In contrast, no immunoreactivities for α-methylacyl-CoA racemase, RCC marker, glutathione S-transferase α or C-KIT were detected. The immunophenotypic profile of clear cell papillary cystadenocarcinoma of the epididymis closely resembles that of clear cell papillary RCC, although the immunohistochemical markers tested in this study are useful to make a differential diagnosis between clear cell papillary cystadenocarcinoma of the epididymis and metastatic clear cell RCC.
Subject(s)
Adenocarcinoma, Clear Cell/diagnosis , Carcinoma, Renal Cell/diagnosis , Cystadenocarcinoma, Papillary/diagnosis , Epididymis/pathology , Testicular Neoplasms/diagnosis , Adenocarcinoma, Clear Cell/metabolism , Adenocarcinoma, Clear Cell/surgery , Aged , Biomarkers, Tumor/metabolism , Carcinoma, Renal Cell/metabolism , Carcinoma, Renal Cell/secondary , Cystadenocarcinoma, Papillary/metabolism , Cystadenocarcinoma, Papillary/surgery , Diagnosis, Differential , Epididymis/metabolism , Humans , Male , Orchiectomy , Testicular Neoplasms/metabolism , Testicular Neoplasms/surgeryABSTRACT
A 69-year-old man visited our hospital with complaints of hoarseness and dysphagia. Computed tomography showed wall thickening in the middle thoracic esophagus, tracheal invasion, and para-aorta lymph node swelling. An esophagoscopy revealed an elevated lesion in the middle portion of the esophagus, which was pathologically diagnosed as neuroendocrine carcinoma, stage IV: T4N3M1. Two courses of concurrent chemoradiotherapy using cisplatin and etoposide were performed, followed by 4 courses of combined chemotherapy with carboplatin and etoposide. The patient showed clinical complete remission.
Subject(s)
Carcinoma, Neuroendocrine/therapy , Chemoradiotherapy , Esophageal Neoplasms/therapy , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Carcinoma, Neuroendocrine/pathology , Esophageal Neoplasms/pathology , Humans , Male , Tomography, X-Ray ComputedABSTRACT
It is important to recognize and understand focal fatty infiltration and pseudolesions of the liver mimicking liver tumors on CT during arterial portography or helical-CT images. These conditions are caused by venous flow outside the main portal vein. Unless this is borne in mind, incorrect diagnosis and management may follow. This article demonstrates the appearance of the parenchymal changes caused by systemic venous flow and location of the systemic veins entering the liver parenchyma.
