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1.
Pediatr Surg Int ; 30(8): 815-22, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25052255

ABSTRACT

PURPOSE: Intestinal neuronal dysplasia Type B (IND-B) has been proposed to be an allied disorder of Hirschsprung's disease (ADHD). The original histological criteria included hyperganglionosis, giant ganglia, ectopic ganglion cells and an increased AChE activity in the lamina propria. The criteria for IND-B have been gradually revised. The present diagnostic criteria are [1] more than 20 % of the submucosal ganglia contain nine or more ganglion cells and [2] the patient is older than 1 year. To clarify the current status of IND-B in Japan, a nationwide retrospective cohort study was performed. METHODS: Questionnaires were sent to 161 major institutes of pediatric surgery and gastroenterology in Japan. RESULTS: A total of 355 cases of ADHD were collected, including 18 cases of IND-B (5 %). Based on original criteria, 13 out of 18 cases were diagnosed as IND-B. However, only four cases met the current criteria. Three of the four patients (75 %) required pull-through operation. All of the patients exhibited giant ganglia and ganglioneuromatosis-like hyperplasia of the myenteric plexus. CONCLUSIONS: IND-B cases matching the current criteria are thought to be quite rare and they are associated with marked hyperplasia of the myenteric plexus. "True" IND-B is a rare and intractable disease.


Subject(s)
Enteric Nervous System/pathology , Hirschsprung Disease/pathology , Intestinal Mucosa/innervation , Submucous Plexus/pathology , Adolescent , Child , Child, Preschool , Female , Hirschsprung Disease/epidemiology , Humans , Incidence , Intestinal Mucosa/pathology , Japan/epidemiology , Male , Retrospective Studies , Surveys and Questionnaires
3.
Kyobu Geka ; 60(7): 526-8, 2007 Jul.
Article in Japanese | MEDLINE | ID: mdl-17642211

ABSTRACT

Combination of congenital cardiovascular and other anomalies are often found. Combined operation is needed for some of these cases. We report 3 cases who underwent combined operations by combined team of cardiovascular and general surgical units. Case 1: A 10-month-old boy with VATER association was complicated with tetralogy of Fallot, double aortic arch and so on. He underwent division of left aortic arch for vascular ring by cardiovascular surgical unit and esophagogastrostomy for esophageal atresia by general surgical unit. Case 2: A 15-day-old girl with patent ductus arteriosus and eventration of the diaphragm underwent ligation of ductus arteriosus by cardiovascular surgical unit and plication of left diaphragm by general surgical unit. Case 3: An 8-month-old boy with tracheobronchomalacia and atrial septal defect underwent atrial septal defect (ASD) closure by cardiovascular, and extra tracheobronchial stenting on cardiopulmonary bypass by cardiovascular and general surgical unit. These 3 operations were successful, and we consider that combined operation is useful for certain surgical congenital multiple anomalies.


Subject(s)
Abnormalities, Multiple/surgery , Heart Defects, Congenital/surgery , Surgical Procedures, Operative/methods , Female , Humans , Infant , Infant, Newborn , Male , Patient Care Team , Perioperative Care , Treatment Outcome
5.
Surg Endosc ; 17(2): 278-81, 2003 Feb.
Article in English | MEDLINE | ID: mdl-12364995

ABSTRACT

BACKGROUND: Laparoscopic findings of levator muscle and the efficacy of laparoscopic muscle stimulator (LMS) in infants with high imperforate anus have not been reported. METHODS: Twelve patients underwent laparoscopically assisted anorectoplasty for high imperforate anus. Following laparoscopic dissection of the distal rectum and division of the fistula, levator muscles in the pelvic floor were stimulated with a 5-mm-diameter LMS. Dilatation was done by inserting a guidewire and balloon catheter through the center of the levator muscle sling and muscle complex. Rectal pull-through and anastomosis between the rectum and anus were successfully completed. RESULTS: LMS showed good contraction of levator muscles and enhanced accurate midline placement of pull-through rectum. LMS was particularly useful in observing weak muscles in infants with rectovesical fistula. CONCLUSIONS: Laparoscopy and LMS offer excellent visualization of the pelvic musculature and precise tract of rectal pull-through. Fecal continence will be assessed by long-term follow-up.


Subject(s)
Anus, Imperforate/therapy , Laparoscopy/methods , Muscle, Skeletal/physiopathology , Pelvic Floor/physiopathology , Physical Stimulation/methods , Anal Canal/surgery , Anastomosis, Surgical/methods , Anus, Imperforate/complications , Catheterization/methods , Child, Preschool , Female , Humans , Infant , Male , Muscle Contraction , Rectovaginal Fistula/complications , Rectovaginal Fistula/surgery , Rectum/surgery , Urethral Diseases/complications , Urethral Diseases/surgery
8.
J Pediatr Surg ; 36(11): 1633-6, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11685689

ABSTRACT

BACKGROUND/PURPOSE: In infants, neuroblastoma has been known to spontaneously differentiate into a benign ganglioneuroma. Although several investigators have compared mass-screened with unscreened, disseminated with localized, and adrenal with retroperitoneal neuroblastoma, there are very few cross-comparisons of the above parameters. Herein, the authors report the maturation of mass-screened, localized adrenal neuroblastoma. METHODS: Fifty-one mass-screened adrenal neuroblastomas were divided into 2 groups. In infants less than 1 year of age (Group A), 45 neuroblastomas were resected, whereas 6 neuroblastomas were resected after observation in 1- to 4-year-old children (group B). Histopathology of the tumors in the 2 groups was compared. Data were analyzed by X(2) test, and P <.05 was considered significant. RESULTS: According to the International Neuroblastoma Pathological Classification, 41 of 45 tumors of group A were "differentiating neuroblastoma" and 4 of 6 tumors of group B were "maturing ganglioneuroma." Maturation toward ganglioneuroblastoma was observed in 16 neuroblastomas of group A (36%) and 6 neuroblastomas of group B (100%). In group A, 58% had low mitosis karyorrhexis index (MKI); all patients in group B had low MKI. CONCLUSIONS: If left untreated, maturation of mass-screened, localized adrenal neuroblastomas is a common phenomenon. These children do not need to undergo early operation.


Subject(s)
Adrenal Gland Neoplasms/pathology , Ganglioneuroma/pathology , Neuroblastoma/pathology , Adrenal Gland Neoplasms/classification , Child , Child, Preschool , Ganglioneuroma/classification , Humans , Infant , Mass Screening , Neoplasm Regression, Spontaneous , Neoplasm Staging , Neuroblastoma/classification
9.
Surg Endosc ; 15(7): 751-4, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11591983

ABSTRACT

BACKGROUND: The role of laparoscopy in children with cancer has not been fully defined. The aims of this study were to develop an optimal surgical procedure for the treatment of abdominal neuroblastoma in the laparoscopic era and to evaluate the advantages and disadvantages of laparoscopy in the pediatric population. METHODS: Since July 1997, 37 children were diagnosed with abdominal neuroblastoma at our center, and 44 surgical procedures were performed on them. Patients with advanced neuroblastoma underwent laparoscopic biopsy, open biopsy, and delayed primary or second-look excision, whereas early neuroblastoma cases had either laparoscopic or open excision. We compared the length of the operation, intraoperative blood loss, length of hospital stay, complications, and time to start postoperative feeding and chemotherapy for the laparoscopic and open surgery groups. RESULTS: Length of stay and time to postoperative feeding and chemotherapy were significantly lower in the laparoscopic group than the open surgery group. However, there were no significant differences between the two groups in length of operation and intraoperative blood loss. CONCLUSION: Laparoscopic biopsy and excision of abdominal neuroblastoma are effective and efficient surgical procedures in children.


Subject(s)
Abdominal Neoplasms/surgery , Laparoscopy/methods , Neuroblastoma/surgery , Adolescent , Adrenalectomy/methods , Age Factors , Child , Child, Preschool , Female , Humans , Infant , Male , Retroperitoneal Neoplasms/surgery , Treatment Outcome
10.
Surg Endosc ; 15(5): 489-92, 2001 May.
Article in English | MEDLINE | ID: mdl-11353967

ABSTRACT

BACKGROUND: The laparoscopic procedure involving total resection of abdominal neuroblastoma combined with lymphadenectomy has not been reviewed in English literature. The aim of this study was to evaluate the significance and accuracy of laparoscopic resection of abdominal neuroblastoma. METHODS: Since July 1997, five patients with abdominal neuroblastoma underwent laparoscopic resection combined with lymphadenectomy or sampling of the lymph nodes. The length of operation, intraoperative blood loss, resectability, and complications were retrospectively reviewed and evaluated. RESULTS: Four cases were managed laparoscopically, but one case was converted to open procedure because of poor visualization around large vessels. The mean operation time was 135 min and the intraoperative blood loss 52 ml. CONCLUSIONS: Good visualization of the primary tumor and large vessels is, arguably, the most important factor for successful completion of this procedure laparoscopically. Precise indicators for laparoscopic resection of abdominal neuroblastoma provide a better prognosis and a good quality of life for children with neuroblastoma.


Subject(s)
Adrenal Gland Neoplasms/surgery , Laparoscopy/methods , Lymph Node Excision/methods , Neuroblastoma/surgery , Retroperitoneal Neoplasms/surgery , Child , Child, Preschool , Humans , Retroperitoneal Space , Retrospective Studies
11.
Pediatr Surg Int ; 16(1-2): 118-20, 2000.
Article in English | MEDLINE | ID: mdl-10663858

ABSTRACT

The role of pre- and intraoperative procedures for the localization of insulinomas has been extensively debated. We report a case of successful treatment using preoperative selective intra-arterial calcium injection and intraoperative glucose monitoring. A 12-year-old boy with hypoglycemic attacks had a large insulinoma in the head of the pancreas on computed tomography. Preoperative selective angiography combined with arterial stimulation-venous sampling (ASVS) by intra-arterial injection of calcium revealed no other insulinomas in the body and tail of the pancreas. Elevation of serum glucose on intraoperative monitoring confirmed complete enucleation of the insulinoma. Preoperative ASVS can accurately localize an insulinoma, and may help to increase the success rate of surgery and avoid blind pancreatectomy.


Subject(s)
Blood Glucose/metabolism , Calcium Gluconate , Insulinoma/surgery , Pancreatic Neoplasms/surgery , Calcium Gluconate/administration & dosage , Child , Humans , Injections, Intra-Arterial , Insulin/blood , Insulinoma/diagnosis , Male , Pancreatic Neoplasms/diagnosis
12.
Pediatr Int ; 42(6): 608-12, 2000 Dec.
Article in English | MEDLINE | ID: mdl-11192515

ABSTRACT

BACKGROUND: Laparoscopic surgery in small infants is still an uncommon procedure in Japan. The present study was conducted to evaluate the advantages and disadvantages of laparoscopic surgery in neonates and infants weighing less than 5 kg. METHODS: Between July 1997 and November 1999, 54 infants underwent laparoscopic surgery. They were evaluated for length of operation, intra- and postoperative complications, changes in intra-operative body temperature, time to postoperative feeding, length of hospital stay and changes in serum levels of C-reactive protein (CRP), creatinine phosphokinase (CPK) and interleukin (IL)-6 on days 0, 1 and 4. These parameters in the laparoscopic pyloromyotomy (LP) and laparoscopic fundoplication groups were compared with those in the open pyloromyotomy (OP) and open fundoplication groups, respectively, which were performed during the same period. RESULTS: Three laparoscopy cases were converted to open procedures. One case of fundoplication had panperitonitis due to failed gastrostomy and required long-term parenteral nutrition. Time to postoperative feeding and length of hospital stay in the LP group were significantly shorter than in the OP group. In LP group, intra-operative body temperature did not markedly decrease during CO, pneumoperitoneum. Although serum levels of CRP, CPK and IL-6 were elevated in all groups on postoperative day 1, there were no significant differences between the groups. CONCLUSIONS: Better quality of life after laparoscopy is a significant advantage over conventional surgical procedures. This advantage not only outweighs the incidence of intra- and postoperative complications in small infants, but further emphasizes the need to improve laparoscopic techniques to avoid complications.


Subject(s)
Laparoscopy , Postoperative Complications , Body Weight , C-Reactive Protein/analysis , Creatine Kinase/blood , Humans , Infant, Newborn , Interleukin-6/blood , Laparoscopy/adverse effects , Postoperative Complications/blood , Postoperative Complications/immunology , Postoperative Complications/prevention & control , Postoperative Period , Quality of Life
14.
Pediatr Surg Int ; 13(2-3): 149-53, 1998 Mar.
Article in English | MEDLINE | ID: mdl-9563030

ABSTRACT

Minimally invasive surgery (MIS) for cancer patients has become widely accepted in general surgery, however, it has not completely replaced the standard open operative procedures in pediatric oncology. The aim of this study was to evaluate the host relationship following MIS in a murine model of retroperitoneal neuroblastoma (NB) Immature, 5- to 7-week-old male A/J mice weighing 18-23 g were inoculated with either C1300 or TBJ NB in the left retroperitoneal space. At 4 days (early stage) or 11 days (late stage) following tumor inoculation, the animals underwent a laparotomy or pneumoperitoneum with carbon dioxide under general inhalational anesthesia. Animal survival, tumor growth, and postoperative changes in body weight were observed. In the model of subcutaneous TBJ NB, distant metastases following the laparotomy or MIS technique were also evaluated. Each surgical group had a sample size > or = 12, and data were statistically analyzed by ANOVA and the chi-square test where appropriate. P < 0.05 was considered to be significant. There were no significant differences in animal survival, tumor growth, or distant metastases among surgical groups in any combination of type and stage of tumor. The only salutary influence of MIS was seen in a model of early-stage NB, where the decrease in body weight on postoperative day 7 was preserved when compared to post-laparotomy weight loss. We conclude that when compared to conventional laparotomy, the MIS access technique does not influence the outcome in a model of retroperitoneal murine NB.


Subject(s)
Neuroblastoma/surgery , Retroperitoneal Neoplasms/surgery , Animals , Disease Models, Animal , Laparotomy , Male , Mice , Mice, Inbred A , Minimally Invasive Surgical Procedures , Neuroblastoma/secondary , Retroperitoneal Neoplasms/pathology , Treatment Outcome , Tumor Cells, Cultured
15.
J Pediatr Surg ; 33(3): 457-61, 1998 Mar.
Article in English | MEDLINE | ID: mdl-9537557

ABSTRACT

BACKGROUND/PURPOSE: Although minimally invasive surgery (MIS) has been broadly applied in patients with cancer of the gastrointestinal tract, the etiology of port-site tumor recurrence (PSR) after laparoscopic cancer surgery remains unclear. The authors report here an analysis of PSR in a model of murine neuroblastoma after laparoscopic tumor biopsy and propose a mechanism for this complication as well as a potential treatment. METHODS: Immature 5- to 7-week old male A/J mice (18-23 g) were subcutaneously inoculated with the minimally immunogenic TBJ-neuroblastoma (TBJ-NB) in the left flank and divided into three treatment groups. The following operations were performed 14 days after tumor inoculation: group 1, additional intraperitoneal or intravenous injection of TBJ-NB during CO2 pneumoperitoneum; group 2, simulated transperitoneal tumor biopsy using MIS techniques during either CO2 pneumoperitoneum or gasless suspension; Group 3, intraperitoneal (IP) or intravenous (IV) administration of cyclophosphamide on postoperative days 0 and 3 to prevent PSR after simulated tumor biopsy during CO2 pneumoperitoneum. RESULTS: In group 1, the incidence of PSR was 0% in the intravenously injected mice versus 63% in mice injected intraperitoneally with TBJ-NB. In group 2, no significant difference in the incidence of PSR was seen between simulated tumor biopsy (89%) animals with CO2 pneumoperitoneum versus animals with gasless suspension (81%). In group 3, mice that did not receive any chemotherapy had an 89% incidence of PSR. Administration of cyclophosphamide via either the IP or IV route effectively prevented PSR, although there was no difference in the incidence of PSR between the two routes (IP 12% versus IV 13%). CONCLUSIONS: The data suggest that PSR in tumor-bearing hosts may be caused by direct seeding of exfoliated tumor cell, and not by hematogenous metastases. Contrary to the other reports, CO2 pneumoperitoneum was not found to be essential for the development of PSR. Furthermore, the authors conclude that postoperative chemotherapy may be useful in preventing PSR after MIS in patients bearing chemotherapy-sensitive tumors such as neuroblastoma.


Subject(s)
Laparoscopy/adverse effects , Neoplasm Recurrence, Local , Neoplasm Seeding , Neuroblastoma/pathology , Animals , Antineoplastic Agents/administration & dosage , Biopsy, Needle/adverse effects , Male , Mice , Neoplasm Recurrence, Local/etiology , Neoplasm Recurrence, Local/prevention & control , Neoplasm Transplantation , Neuroblastoma/secondary , Peritoneal Neoplasms/pathology , Pneumoperitoneum, Artificial/adverse effects
16.
Pediatr Surg Int ; 12(7): 505-8, 1997 Sep.
Article in English | MEDLINE | ID: mdl-9238117

ABSTRACT

Precise staging of malignant disease is required to define the optimum therapeutic strategy. In spite of technical advances, the sensitivity of conventional imaging techniques is usually limited to defining lesions of at least 1 cm in size. Laparoscopy is a sensitive technique that is very valuable for visual inspection of the abdominal cavity and the identification of small surface lesions. However, non-superficial lesions may escape detection due to the lack of tactile sensitivity. As an adjunct to laparoscopy, this study, utilizing a young swine model, has analyzed the detectability of intra-abdominal lymph nodes by laparoscopic ultrasound (LU). Lymph nodes in and around the hepatoduodenal ligament, examined and measured by LU, were resected by subsequent open laparotomy in eight young, mixed-breed swine. The numbers and sizes of lymph nodes detected by LU and resected at laparotomy were compared and analyzed statistically. Forty-six lymph nodes were resected by laparotomy, while LU failed to detect 3 small nodes (sensitivity, 43/46 = 93.5%). The sizes of lymph nodes in the LU group correlated strongly with the sizes actually measured in the laparotomy group (r = 0.936, P < 0.001). Twenty-six small lymph nodes, which conventional extracorporeal imaging might have failed to diagnose, were detected accurately by LU (r = 0.877, P < 0.001). This new technology may not only be effective for staging intra-abdominal malignant disease, but adds the benefit of obtaining tissue samples under direct vision using minimally invasive techniques.


Subject(s)
Lymph Nodes/diagnostic imaging , Lymphatic Metastasis/diagnostic imaging , Neoplasm Staging/methods , Abdomen , Animals , Feasibility Studies , Laparoscopy , Sensitivity and Specificity , Swine , Ultrasonography, Interventional
17.
J Am Coll Surg ; 184(4): 357-63, 1997 Apr.
Article in English | MEDLINE | ID: mdl-9100680

ABSTRACT

BACKGROUND: Laparoscopic operative procedures have decreased postoperative pain and the length of hospitalization. In addition, evidence supports a physiologic benefit from laparoscopic surgery. By analyzing several parameters of peritoneal macrophage function, we report a comparison of the magnitude of postoperative stress between two types of minimally invasive access techniques contrasted with an open laparotomy, in a murine model. STUDY DESIGN: Immature male A/J mice were exposed to pneumoperitoneum using carbon dioxide, gasless suspension, or laparotomy. Peritoneal macrophages were then harvested, and the number and viability of the macrophages from each group of mice were compared. Last, as a marker of postoperative stress, the in vitro production of nitric oxide and tumor necrosis factor alpha by these macrophages was determined. RESULTS: The number of peritoneal macrophages and the viability of the macrophages in the laparotomy group were significantly decreased 4 hours after operation compared with the minimally invasive and control groups. In addition, macrophage production of tumor necrosis factor alpha and nitric oxide, two markers of macrophage stress, 24 hours after operation was significantly increased in the laparotomy group compared with animals serving as controls. Gasless suspension and pneumoperitoneum decreased the number of macrophages to a lesser degree than did open laparotomy and did not affect macrophage viability. Moreover, gasless suspension and pneumoperitoneum did not lead to an increase in tumor necrosis factor alpha or nitric oxide production by peritoneal macrophages. CONCLUSIONS: Postoperative stress, assessed by a decrease in macrophage viability and an increase in cytotoxic cytokine production, is maximized after laparotomy compared with stress in murine hosts that underwent minimally invasive treatment. These data provide basic scientific evidence for the possible physiologic benefit of minimally invasive techniques.


Subject(s)
Laparoscopy , Macrophages, Peritoneal/physiology , Minimally Invasive Surgical Procedures , Stress, Physiological/physiopathology , Animals , Cell Survival , Male , Mice , Mice, Inbred Strains , Nitric Oxide/biosynthesis , Pneumoperitoneum, Artificial , Tumor Necrosis Factor-alpha/biosynthesis
18.
Surgery ; 119(4): 431-6, 1996 Apr.
Article in English | MEDLINE | ID: mdl-8644009

ABSTRACT

BACKGROUND: Because graft arteries are smaller and shorter in living-related liver transplantation (LRLT) than in whole or reduced-size liver transplantation from cadavers, arterial reconstruction is thought to be one of the critical points for success. METHODS: Thirty LRLT patients were classified into two groups: those in whom all graft hepatic arteries were reconstructed (group A), and those whom only had some were reconstructed (group B). In group A 17 patients had a single hepatic artery and three had two hepatic arteries. In group B the thickest one of several arteries was reconstructed, but the others were ligated after pulsatile back-bleeding from their cut stumps had been confirmed. The clinical results were compared between the two groups. RESULTS: Neither arterial thrombosis nor liver dysfunction related to the arterial blood supply was observed during the postoperative course. One case of bile leakage and two cases of bile duct stenosis occurred in group A. No significant difference was noted in the postoperative values of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase between the two groups. Overall patient and graft survival was 90%. CONCLUSIONS: Although several hepatic arteries may supply the potential allograft in LRLT, it is not always necessary to reconstruct all of them.


Subject(s)
Hepatic Artery/surgery , Liver Transplantation , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , Male
19.
J Pediatr Surg ; 30(12): 1724-7, 1995 Dec.
Article in English | MEDLINE | ID: mdl-8749937

ABSTRACT

Two cases of esophageal duplication cyst associated with pulmonary cystic malformations (cystic bronchiectasis with pneumonia in one, intrapulmonary bronchogenic cysts with bronchial atresia in the other) are reported. The coexistence of these complex anomalies supports the recognition that esophageal duplication cyst also is an entity of a broad spectrum of developmental abnormalities caused by abnormal budding of the primitive foregut. Nine cases of similar complex anomalies in the lung and esophagus have been reported. Although rare, this malformation complex should be borne in mind in the treatment of pediatric mediastinal and pulmonary malformations.


Subject(s)
Abnormalities, Multiple/surgery , Cystic Adenomatoid Malformation of Lung, Congenital/surgery , Cysts/congenital , Esophagus/abnormalities , Abnormalities, Multiple/diagnostic imaging , Abnormalities, Multiple/pathology , Bronchiectasis/diagnostic imaging , Bronchiectasis/pathology , Bronchiectasis/surgery , Child , Child, Preschool , Cystic Adenomatoid Malformation of Lung, Congenital/diagnostic imaging , Cystic Adenomatoid Malformation of Lung, Congenital/pathology , Cysts/diagnostic imaging , Cysts/pathology , Cysts/surgery , Esophagus/pathology , Esophagus/surgery , Female , Humans , Lung/pathology , Male , Pneumonectomy , Tomography, X-Ray Computed
20.
J Pediatr Surg ; 30(12): 1743-5, 1995 Dec.
Article in English | MEDLINE | ID: mdl-8749943

ABSTRACT

A 5-month-old boy who was diagnosed as having hydrops fetalis at 25 weeks' gestation had severe ascites of unknown origin. At the age 12 months, ultrasonography and computed tomography showed multiple cysts in the spleen that were increasing in size rapidly. Splenectomy resulted in complete disappearance of the ascites. These cysts were diagnosed as mesothelial cysts because the cell lining of the splenic cysts stained positively with alcian blue and cytokeratin. The boy's mother had undergone splenectomy for splenic and retroperitoneal lymphangiomas at 4 years of age. Histological reevaluation showed that the lining of her splenic cysts had the same mesothelial components as her son's. Their chromosomal assay showed normal karyotypes. Mesothelial cyst of the spleen appears similar to splenic lymphangioma morphologically; however, bleomycin and OK-432 were not effective. Familial splenic mesothelial (epidermoid) cysts have been reported in three sets of siblings, but this is the first report of their occurrence in mother and son.


Subject(s)
Cysts/genetics , Epithelium , Lymphangioma/genetics , Splenic Diseases/genetics , Splenic Neoplasms/genetics , Adult , Cysts/pathology , Cysts/surgery , Diagnosis, Differential , Epithelium/pathology , Female , Humans , Infant , Lymphangioma/pathology , Lymphangioma/surgery , Male , Spleen/pathology , Splenectomy , Splenic Diseases/pathology , Splenic Diseases/surgery , Splenic Neoplasms/pathology , Splenic Neoplasms/surgery
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