ABSTRACT
A significant accumulation of copper, zinc, iron, rubidium and bromine, in addition to platinum, was observed in kidneys and liver of mice treated with cis-DDP. This observation suggests that the toxicity of cis-DDP is due to the overall accumulation of trace elements and not only to the expected high platinum levels. Sodium selenite administration prior to cis-DDP results in fast clearance of all these trace elements from kidneys and liver; control levels are reached within 6 days. This may explain the important reduction in cis-DDP toxicity following selenite administration. An X-ray fluorescence (XRF) facility was used for the evaluation of the trace elements.
Subject(s)
Cisplatin/toxicity , Selenium/pharmacology , Trace Elements/analysis , Animals , Cisplatin/antagonists & inhibitors , Female , Metabolic Clearance Rate/physiology , Mice , Mice, Inbred ICR , Sodium Selenite , Trace Elements/pharmacokineticsABSTRACT
The present study was undertaken to assess the contribution of phosphate feed supplements to the radiation exposure of the population in Israel. The phosphates usually contain appreciable quantities of U and its daughters and the actual exposure of human consumers depends, to a very large extent, on the degree of equilibrium of the decay chain in the feed and through the metabolic process. The concentrations of 238U, 234U, 226Ra and 210Po (210Pb) in poultry feed supplements and in chicken meat (breasts, thighs) and organs (livers, spleens, gizzards) as well as in eggs were determined. From the results, the transfer coefficients of U and Po in chicken meat and in eggs were calculated. The effective dose equivalent to the Israeli population due to the consumption of poultry products which accounts for approximately 70% of all meat consumed in Israel is assessed to be 0.04 mSv y-1.
Subject(s)
Animal Feed/analysis , Food Contamination, Radioactive/analysis , Polonium/analysis , Potassium Compounds , Poultry Products/analysis , Uranium/analysis , Animals , Chickens , Eggs/analysis , Food, Fortified/analysis , Humans , Hydroxides/analysis , Israel , Potassium/analysis , Radiation DosageABSTRACT
Selenium and other trace elements (Cu, Zn, Br, and Rb) were determined in very small (0.75 microL) human serum and mice whole blood samples, by an XRF method. Accurate results of elemental concentration were obtained without the need of exact volume measurement, because of the backscatter correction used. The XRF method is highly sensitive (M.D.L. = 0.06, 0.13, 0.09, 0.07, and 0.05 ppm for Se, Cu, Zn, Br, and Rb, respectively), rapid (counting time--100 s/sample), easy to perform and therefore suitable for routine trace element analyses. The results obtained are in good agreement with the values reported in the literature.
