[Metabolism of xenobiotics in the liver in acute hypoxia of intact mice and mice adapted to oxygen deficiency]. / Metabolizm ksenobiotikov v pecheni pri ostroi gipoksii u intaktnykh i adaptirovannykh k nedostatku kisloroda myshei.

Experiments on white mice were made to study the effect of acute hypoxia in intact and hypoxia adapted animals on the function of liver hydroxylases. It was shown that acute hypoxia (vacuum 462 Pa, exposure 120 min) leads to a decrease in the rate of amidopyrine demethylation by liver microsomal enzymes. Preadaptation to hypoxia reduces the depth of microsomal hydroxylation inhibition in response to hypoxia. Variation in the constant of substrate binding with the enzymatic complex plays in important role in the mechanism of microsomal oxidation inhibition in the liver under hypoxia. The concentration of the hemoproteins P = 450 and b5 does not undergo any substantial changes.

[Comparison of the effect of acute hypoxia on the rat liver lysosomal apparatus against a background of adaptation to hypoxia and the administration of gutimine]. / Sravnenie vliianiia ostroi gipoksii na lizosomal'nyi apparat pecheni krys na fone adaptatsii k gipoksii i vvedeniia gutimina.

Acute hypobaric hypoxia in rats (260 mm Hg., 90 min) was accompanied by a greater liver lysosomes osmotic susceptibility and by an increase in the relative content of the lysosomal enzymes (acid RNAase and acid phosphatase) in the nuclear fraction. This indicates an enrichment of the liver cell lysosomes with secondary lysosomes. No significant signs of labilization of the liver lysosomes were found. The adaptation of rats to hypoxia, as well as administration of the antihypoxant guthimin or of 1,4-bis-(3'-morpholinopropin-1'-yl-1') benzene hinder these changes to occur in the liver lysosomes during the organism reaction to hypoxia. But the effect of stabilization of the lysosomal membranes in a minor component in the antihypoxia action of the treatment.

[Stabilization of biological membranes with various acetylene amines]. / Stabilizatsiia biologicheskikh membran nekotorymi atsetilenovymi aminami.

In experiments with mitochondrial membranes and membranes of the endoplasmatic reticulum of the rats' liver the membrane-stabilizing action of a number of unsaturated amines was evaluated. The acetylene compounds studied reduced the extent of the membranes damage following UV-irradiation, treatment with detergents and their incubation in a hypoosmotic medium. Such an action displayed gutimine and sovcaine. Hydrated compounds, analogues of acetylene amines are devoid of the ability to raise the resistance of the cellular organoids membranes to damaging factors

[Peroxidative oxidation of lipids and the antioxidative activity of acetylene amine]. / Perekisnoe okislenie lipidov i antiokislitel'naia aktivnost' atsetilenovykh aminov

The study acetylene amines were capable of inhibiting the processes of lipids peroxidation both in the enzymatic and non-enzymatic peroxidation system. The inhibitory effect of the study compounds depended upon the degree of the compound unsaturation. An elevation of the unsaturation degree to a definite extent is attended also by an increased inhibitory action on the processes of the lipids peroxidation.