ABSTRACT
Significantly lower frequency of relapse, incidence of pulmonitis and pericarditis, leukopenia and thrombocytopenia stage IV and longer recurrence-free survival were reported after acceleration of multifractionation of STD of 1.35Gy was used for treatment of patients with primary Hodgkin's disease, as compared with standard fractionation. When STD was reduced to 1.2Gy (modified multifractionation), subtotal exposure of lymph nodes was followed by a significant drop in frequency and severity of leukopenia and thrombocytopenia stage III-IV. The latter complications, rates decreased further, with perspective response to therapy, as irradiation was limited to that of areas exposed during modified multifractionation.
Subject(s)
Dose Fractionation, Radiation , Hodgkin Disease/radiotherapy , Adult , Aged , Biomedical Research , Disease-Free Survival , Female , Humans , Incidence , Kaplan-Meier Estimate , Leukopenia/epidemiology , Leukopenia/etiology , Male , Middle Aged , Pericarditis/epidemiology , Pericarditis/etiology , Pneumonia/epidemiology , Pneumonia/etiology , Radiotherapy/adverse effects , Recurrence , Retrospective Studies , Russia/epidemiology , Severity of Illness Index , Thrombocytopenia/epidemiology , Thrombocytopenia/etiology , Treatment OutcomeABSTRACT
An analysis of the clinico-morphological characteristics of 9 so-called "granulomatous thymomas" in female patients aged 15-36 years revealed primary malignant granulomas in the thymus. There were no epithelial structures in extrathoracic lesions, typical of Hodgkin's disease. Therefore, similar therapeutic measures may be taken in treating patients with "granulomatous thymoma" and Hodgkin's disease.
