A monosynaptic pathway from dorsal cochlear nucleus to auditory cortex in rat.

Of the three major subdivisions of the auditory thalamus, the medial subdivision is the only one that receives a direct projection from the dorsal cochlear nucleus. Those cells in the medial auditory thalamus that receive the projection from the dorsal cochlear nucleus continue to the auditory cortex. A combination of anterograde and retrograde anatomical tracer injections made in the dorsal cochlear nucleus and the auditory cortex respectively, revealed terminal boutons which were directly apposed onto the dendrites and cell bodies of neurons in the medial auditory thalamus. The presence of a monosynaptic pathway, which transfers information from the first relay in the auditory system to the last, suggests that this pathway may rapidly convey very basic information to the auditory cortex.

A discontinuous tonotopic organization in the inferior colliculus of the rat.

Audible frequencies of sound are encoded in a continuous manner along the length of the cochlea, and frequency is transmitted to the brain as a representation of place on the basilar membrane. The resulting tonotopic map has been assumed to be a continuous smooth progression from low to high frequency throughout the central auditory system. Here, physiological and anatomical data show that best frequency is represented in a discontinuous manner in the inferior colliculus, the major auditory structure of the midbrain. Multiunit maps demonstrate a distinct stepwise organization in the order of best frequency progression. Furthermore, independent data from single neurons show that best frequencies at octave intervals of approximately one-third are more prevalent than others. These data suggest that, in the inferior colliculus, there is a defined space of tissue devoted to a given frequency, and input within this frequency band may be pooled for higher-level processing.