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Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda.
Bergmann, Clara; van Loon, Welmoed; Habarugira, Felix; Tacoli, Costanza; Jäger, Julia C; Savelsberg, Darius; Nshimiyimana, Fabian; Rwamugema, Elias; Mbarushimana, Djibril; Ndoli, Jules; Sendegeya, Augustin; Bayingana, Claude; Mockenhaupt, Frank P.
Emerg Infect Dis ; 27(1): 294-296, 2021 01.
Article in English | MEDLINE | ID: mdl-33350925

ABSTRACT

Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.


Subject(s)
Antimalarials , Malaria, Falciparum , Antimalarials/pharmacology , Antimalarials/therapeutic use , Drug Resistance/genetics , Humans , Malaria, Falciparum/drug therapy , Malaria, Falciparum/epidemiology , Mutation , Plasmodium falciparum/genetics , Protozoan Proteins/genetics , Rwanda/epidemiology
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