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5.
Health Qual Life Outcomes ; 7: 90, 2009 Oct 16.
Article in English | MEDLINE | ID: mdl-19835583

ABSTRACT

BACKGROUND: The RANGE (Retrospective ANalysis of GastroEsophageal reflux disease [GERD]) study assessed differences among patients consulting a primary care physician due to GERD-related reasons in terms of: symptoms, diagnosis and management, response to treatment, and effects on productivity, costs and health-related quality of life. This subanalysis of RANGE determined the impact of GERD on productivity in work and daily life. METHODS: RANGE was conducted at 134 primary care sites across six European countries (Germany, Greece, Norway, Spain, Sweden and the UK). All subjects (aged >or=18 years) who consulted with their primary care physician over a 4-month identification period were screened retrospectively, and those consulting at least once for GERD-related reasons were identified (index visit). From this population, a random sample was selected to enter the study and attended a follow-up appointment, during which the impact of GERD on productivity while working (absenteeism and presenteeism) and in daily life was evaluated using the self-reported Work Productivity and Activity Impairment Questionnaire for patients with GERD (WPAI-GERD). RESULTS: Overall, 373,610 subjects consulted with their primary care physician over the 4-month identification period, 12,815 for GERD-related reasons (3.4%); 2678 randomly selected patients attended the follow-up appointment. Average absenteeism due to GERD was highest in Germany (3.2 hours/week) and lowest in the UK (0.4 hours/week), with an average of up to 6.7 additional hours/week lost due to presenteeism in Norway. The average monetary impact of GERD-related work absenteeism and presenteeism were substantial in all countries (from euro55/week per employed patient in the UK to euro273/patient in Sweden). Reductions in productivity in daily life of up to 26% were observed across the European countries. CONCLUSION: GERD places a significant burden on primary care patients, in terms of work absenteeism and presenteeism and in daily life. The resulting costs to the local economy may be substantial. Improved management of GERD could be expected to lessen the impact of GERD on productivity and reduce costs.


Subject(s)
Absenteeism , Cost of Illness , Efficiency , Gastroesophageal Reflux , Activities of Daily Living , Adolescent , Europe , Female , Gastroesophageal Reflux/complications , Gastroesophageal Reflux/psychology , Humans , Male , Observation , Quality of Life , Surveys and Questionnaires , Workplace , Young Adult
6.
Curr Med Res Opin ; 25(11): 2777-84, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19785512

ABSTRACT

OBJECTIVE: To describe the management of gastro-oesophageal reflux disease (GERD) in primary care, as part of the RANGE (Retrospective ANalysis of GERD) study. METHODS: Over 4 months, at 134 primary care practices in six European countries, 12 815 patients consulted for GERD-related reasons. A random selection of these patients was invited to enter the study. Data were then collected retrospectively (from the initial consultation) and prospectively (from a follow-up visit). This included information on GERD diagnosis, symptoms and complications, medication use and healthcare resource utilisation. RESULTS: Of 12 815 patients who underwent consultation for GERD-related reasons, 2678 were randomly selected and accepted the invitation to participate in the study. Across countries, 28-47% of patients reported a significant GERD symptom load at initial consultation. Thereafter, 30-100% of patients were prescribed a proton pump inhibitor (PPI), but a significant GERD symptom load was still experienced by 15-30% (all patients combined) at follow-up (median 5.0-7.5 months after initial consultation). In the majority of patients (65-88%), no diagnostic procedures were performed between initial consultation and follow-up. During the follow-up period, the most common form of healthcare utilisation comprised additional GERD-related consultations with a physician. CONCLUSIONS: The findings of this pan-European study indicate that current management of primary care patients with GERD is far from optimal, and accounts for a marked burden on patients and healthcare systems alike. A more structured approach to GERD management, by tailoring treatment according to the impact of the disease, may reduce this burden.


Subject(s)
Gastroesophageal Reflux/therapy , Primary Health Care , Adult , Aged , Algorithms , Anti-Ulcer Agents/therapeutic use , Europe/epidemiology , Female , Gastroesophageal Reflux/diagnosis , Gastroesophageal Reflux/epidemiology , Health Resources/statistics & numerical data , Humans , Male , Middle Aged , Office Visits/statistics & numerical data , Practice Patterns, Physicians' , Recurrence , Retrospective Studies
8.
Health Qual Life Outcomes ; 7: 60, 2009 Jul 02.
Article in English | MEDLINE | ID: mdl-19573227

ABSTRACT

BACKGROUND: The impact of gastroesophageal reflux disease (GERD) on the daily lives of patients managed in primary care is not well known. We report the burden of GERD in a large population of patients managed in primary care, in terms of symptoms and impact on patients' daily lives. METHODS: RANGE (Retrospective ANalysis of GERD) was an observational study that was conducted at 134 primary care sites across six European countries. All adult subjects who had consulted their primary care physician (PCP) during a 4-month identification period were screened retrospectively and those consulting at least once for GERD-related reasons were identified. From this population, a random sample of patients was selected to enter the study and attended a follow-up appointment, during which the Reflux Disease Questionnaire (RDQ), the GERD Impact Scale (GIS) and an extra-esophageal symptoms questionnaire were self-administered. Based on medical records, data were collected on demographics, history of GERD, its diagnostic work-up and therapy. RESULTS: Over the 4-month identification period, 373,610 subjects consulted their PCP and 12,815 (3.4%) did so for GERD-related reasons. From 2678 patients interviewed (approximately 75% of whom reported taking medication for GERD symptoms), symptom recurrence following a period of remission was the most common reason for consultation (35%). At the follow-up visit, with regard to RDQ items (score range 0-5, where high score = worse status), mean Heartburn dimension scores ranged from 0.8 (Sweden) to 1.2 (UK) and mean Regurgitation dimension scores ranged from 1.0 (Norway) to 1.4 (Germany). Mean overall GIS scores (range 1-4, where low score = worse status) ranged from 3.3 (Germany) to 3.5 (Spain). With regard to extra-esophageal symptoms, sleep disturbance was common in all countries in terms of both frequency and intensity. CONCLUSION: In this large European observational study, GERD was associated with a substantial impact on the daily lives of affected individuals managed in the primary care setting.


Subject(s)
Activities of Daily Living , Gastroesophageal Reflux , Primary Health Care , Quality of Life , Europe , Female , Gastroesophageal Reflux/physiopathology , Gastroesophageal Reflux/psychology , Humans , Male , Middle Aged , Observation , Retrospective Studies
9.
ISME J ; 3(7): 797-807, 2009 Jul.
Article in English | MEDLINE | ID: mdl-19360025

ABSTRACT

This study provides a comprehensive survey of the spatial and temporal bacterial composition of biliary stent biofilms. The bacterial diversity, distribution and dynamics of 59 biliary and 4 pancreatic stent communities from 40 patients being treated at two different hospitals, which implant stents either simultaneously or consecutively, were characterized by single-strand conformation polymorphism (SSCP) analysis. Fifty-one phylotypes belonging to 5 bacterial phyla and 24 bacterial families were detected across 63 stents. This is a much broader diversity than previously detected through culture-dependent methods, particularly in regard to the diversity of obligate anaerobes. Stent bacterial diversity was patient-dependent and more similar when stents were implanted simultaneously rather than consecutively. Stent bacterial community composition differed between hospitals specifically because of the difference in abundance of Bifidobacteria. Co-colonization of Veillonella sp., Streptococcus anginosus and organisms closely related to Fusobacterium nucleatum revealed a potentially important attachment and survival strategy that has yet to be reported in biliary stents. This work reveals a more complete survey of the identities of bacterial species that form biofilms in biliary stents, their co-colonization patterns and the natural variation in species composition between different patients, hospitals and locations along the stent. Consideration of the community composition from individual patients will allow tailoring of prophylactic antibiotic treatments and thus will make the management of stent biofilms more effective.


Subject(s)
Bacteria/classification , Bacteria/isolation & purification , Biodiversity , Common Bile Duct/microbiology , Stents/microbiology , Cluster Analysis , DNA, Ribosomal/genetics , Humans , Molecular Sequence Data , Phylogeny , Polymorphism, Single-Stranded Conformational , RNA, Ribosomal, 16S/genetics , Sequence Analysis, DNA
10.
Eur J Gen Pract ; 15(3): 154-60, 2009 Nov.
Article in English | MEDLINE | ID: mdl-21047190

ABSTRACT

OBJECTIVE: To report on the primary care consultation rates and clinical characteristics of patients with gastro-oesophageal reflux disease (GERD) as part of the RANGE (Retrospective ANalysis of GERD) observational study. METHODS: RANGE was conducted at 134 primary care centres across six European countries. All subjects who consulted their primary care physician during a 4-month identification period were screened retrospectively. Those consulting for GERD-related reasons were identified, and a randomly selected cohort underwent clinical interview. RESULTS: Out of 373,610 consultations in the six countries, 12,815 (3.4%) were for GERD-related reasons (inter-country range: 1.4-7.4%). From 2678 patients interviewed (24.7% of whom had been previously diagnosed with reflux oesophagitis), symptom recurrence following remission was the most common reason for primary care consultation (35.1%; range: 22.3-51.7%). Some 12.7% of patients (range: 9.1-21.4%) consulted due to persistence of previous symptoms, and 16.2% (range: 8.2-35.6%) had never consulted before regarding GERD-related symptoms. CONCLUSION: consultation rates for GERD-related reasons, and the clinical characteristics of consulting patients, vary widely across Europe. Symptom recurrence after an initial period of remission, and persistent symptoms, were important reasons for consultation, emphasizing the need for improved management of primary care patients with GERD across Europe.


Subject(s)
Gastroesophageal Reflux/therapy , Practice Patterns, Physicians'/statistics & numerical data , Primary Health Care/statistics & numerical data , Referral and Consultation/statistics & numerical data , Adult , Aged , Data Collection , Europe/epidemiology , Female , Gastroesophageal Reflux/epidemiology , Humans , Male , Middle Aged , Recurrence , Retrospective Studies
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