Subject(s)
Autoantibodies/immunology , Autoimmune Diseases of the Nervous System/diagnosis , Autoimmune Diseases of the Nervous System/immunology , Membrane Proteins/immunology , Nerve Tissue Proteins/immunology , Proteins/immunology , Adolescent , Autoimmune Diseases of the Nervous System/therapy , Diagnosis, Differential , Humans , Intracellular Signaling Peptides and Proteins , MaleABSTRACT
A teenage woman migrating from Syria arrived in May 2015 in Germany. She gave birth to a healthy child in early 2016, but became febrile shortly after delivery. Blood cultures revealed Brucella melitensis. In retrospect, she reported contact with sheep in Syria and recurrent pain in the hip joints over about five months before diagnosis of brucellosis. We discuss consequences for adequate treatment of mother and child as well as for clinical and laboratory management.
Subject(s)
Brucella melitensis/isolation & purification , Brucellosis/diagnosis , Refugees , Sheep Diseases/microbiology , Administration, Oral , Adolescent , Animals , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Antibiotics, Antitubercular/administration & dosage , Antibiotics, Antitubercular/therapeutic use , Brucellosis/drug therapy , Brucellosis/microbiology , Doxycycline/administration & dosage , Doxycycline/therapeutic use , Drug Combinations , Emigration and Immigration , Germany , Humans , Rifampin/therapeutic use , Sheep , Syria , Treatment Outcome , ZoonosesABSTRACT
Niemann-Pick disease, a neurovisceral lysosomal lipid storage disorder, is a rare disorder that is unknown to many clinicians. The disease, that often has its onset during childhood or adolescence, shows a polymorphic clinical picture, including psychiatric symptoms. Because of its infrequence, Niemann-Pick disease is diagnosed with an average delay of 6 years. This report presents a case of an adolescent male whose symptoms had led to various hospitalisations and psychiatric diagnoses. When he presented with psychotic symptoms in our department, thorough diagnosis revealed Niemann-Pick disease type C1 as the underlying disease.
