1.
Bioorg Med Chem Lett
; 13(1): 107-10, 2003 Jan 06.
Article
in English
| MEDLINE
| ID: mdl-12467627
ABSTRACT
A novel class of thymidine phosphorylase (TP) inhibitors has been designed based on analogy to the enzyme substrate as well as known inhibitors. Flexible docking studies, using a homology model of human TP, of the designed N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as well as their synthetic precursors provide insight into the observed experimental trends in binding affinity.