Subject(s)
Electrocardiography , Myocardial Infarction/diagnosis , Respiratory Function Tests , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
In a consecutive series of 750 patients with acute myocardial infarction, 11 (1.46%) suffered neurological complications. The pathogenesis of these neurological incidents (embolia or hypotension) remained uncertain in all the cases presented here. Neurological incidents (3 TIA, 8 strokes) were more frequent in elderly patients, in which they represented a very serious complication with high fatality. No clear relationship could be established with infarct size nor with the anticoagulant therapy.
Subject(s)
Myocardial Infarction/complications , Nervous System Diseases/etiology , Aged , Aphasia, Broca/etiology , Cerebrovascular Disorders/etiology , Facial Paralysis/etiology , Female , Hemiplegia/etiology , Humans , Male , Middle Aged , Speech Disorders/etiologyABSTRACT
Following a brief outline on problems concerning methodology, the cause of death is analysed in 110 patients dying from acute myocardial infarction during hospitalization. Autopsy studied were carried out in 78 cases. Of the various causes, the most frequent were forms of contractile insufficiency (EPA, shock, shock + EPA, biventricular congestive heart failure) which were responsible for 50.90% of cases; followed by cardiac rupture (considered in a single group with electromechanic dissociations of the patients not submitted to autopsy studies since in the experience of the Authors cardiac rupture almost always presents with this pattern) with a frequency of 29%. The frequency of arrhythmias, on the other hand, is very low, particularly in the coronary care unit where it is practically a negligible causa mortis 2.72%): even if sudden death, in patients who were not monitored, is included amongst the arrhythmias, the percentage is still only about 10%. Embolism (usually pulmonary, but systemic in one case) was the cause of death in 5 patients (4.54%). Three patients over 80 years of age died from ischemic cerebral episodes. Age, sex, and site of infarction, do not appear, in the present series, to have a determinant effect in the cause of death; a higher frequency of rupture in the female sex was not, for example, confirmed. On the basis of the observations in the present series, any relationship between cardiac rupture and anticoagulating therapy, steroid treatment, application of endocavitary stimulators, or early ambulation is excluded. It is also excluded that reanimation, as hypothesized by some Authors, may be responsible for rupture.
Subject(s)
Myocardial Infarction/mortality , Acute Disease , Adult , Aged , Arrhythmias, Cardiac/mortality , Female , Heart Failure/mortality , Heart Rupture/etiology , Humans , Italy , Male , Middle Aged , Myocardial Infarction/complications , Pulmonary Edema/mortality , Shock, Cardiogenic/mortalitySubject(s)
Mitral Valve Prolapse/etiology , Myocardial Infarction/complications , Acute Disease , Adult , Aged , Female , Humans , Male , Middle AgedSubject(s)
Arrhythmias, Cardiac/etiology , Electrocardiography , Adult , Arrhythmias, Cardiac/diagnosis , Humans , Male , Middle AgedSubject(s)
Amyl Nitrite , Coronary Disease/diagnosis , Heart Auscultation , Heart Murmurs , Phonocardiography , Adolescent , Adult , Aged , Child , Coronary Disease/complications , Humans , Middle Aged , PostureABSTRACT
Isolated rabbit heart with independent perfusion of a small left ventricular area was used to study the effect of manganese ions on aconitine-induced ventricular tachycardia. Manganese chloride 4 mM in Locke solution exhibited a constant preventive or suppressive effect versus aconitum-induced rhythm disorders. It is concluded that the interpretation of aconitine cardiotoxic effects on the sole basis of phase 3 modifications require further evidence, and that an increased diastolic depolarization rate may well explain, at least in this experimental model, the genesis of arrhythmias induced by this drug.
