ABSTRACT
INTRODUCTION: The identification, diagnosis, follow-up, and treatment of patients with secondary progressive multiple sclerosis (SPMS) show significant differences between health care professionals in Argentina. AIM: To provide consensus recommendations on the management of patients with SPMS in Argentina to optimize patient care. DEVELOPMENT: A panel of expert neurologists from Argentina dedicated to the diagnosis and care of multiple sclerosis patients gathered during 2019 and 2020 to carry out a consensus recommendation on the diagnosis and treatment of SPMS patients in Argentina. To achieve consensus, the methodology of 'formal consensus-RAND/UCLA method' was used. Recommendations were established based on published evidence and the expert opinion. Recommendations focused on how to define SPMS and how to follow SPMS patients. CONCLUSION: The recommendations of this consensus guidelines attempt to optimize the care of SPMS patients in Argentina.
TITLE: Consenso sobre la identificación y seguimiento de la esclerosis múltiple secundaria progresiva en Argentina.Introducción. Existen diferencias significativas en el diagnóstico, la identificación y el seguimiento de pacientes con esclerosis múltiple secundaria progresiva (EMSP) entre los profesionales de la salud a cargo de su tratamiento. Objetivo. Proveer recomendaciones sobre el tratamiento de los pacientes con EMSP en Argentina con el fin de optimizar su cuidado. Desarrollo. Un grupo de neurólogos expertos en esclerosis múltiple de Argentina elaboró un consenso para el tratamiento de pacientes con EMSP en la región mediante metodología de ronda de encuestas a distancia y reuniones presenciales. Se establecieron 33 recomendaciones basadas en la evidencia publicada y en el criterio de los expertos que participaron. Las recomendaciones se enfocaron en el diagnóstico y el seguimiento de los pacientes con EMSP. Conclusión. Las recomendaciones establecidas en el presente consenso permitirían optimizar el cuidado y el seguimiento de los pacientes con EMSP en Argentina.
Subject(s)
Multiple Sclerosis, Chronic Progressive/diagnosis , Multiple Sclerosis, Chronic Progressive/therapy , Argentina , Humans , Practice Guidelines as TopicABSTRACT
During the last 20 years increasing experimental evidence has associated organic acid metabolism with plant tolerance to environmental stress. Current knowledge shows that organic acids not only act as intermediates in carbon metabolism but also as key components in mechanisms that some plants use to cope with nutrient deficiencies, metal tolerance and plant-microbe interactions operating at the root-soil interphase. In this review we summarize recent knowledge on the physiology and occurrence of organic acids in plants and their special relevance concerning nitrate reduction, phosphorus and iron acquisition, aluminum tolerance and soil ecology. We also discuss novel findings in relation to the biotechnological manipulation of organic acids in transgenic models ranging from cell cultures to whole plants. This novel perspective of organic acid metabolism and its potential manipulation may represent a way to understand fundamental aspects of plant physiology and lead to new strategies to obtain crop varieties better adapted to environmental and mineral stress.
ABSTRACT
The effect of alpha-asarone, a chemical with hypocholesterolemic properties extracted from Guatteria gaumeri, on SCE induction was studied both in human lymphocytes in vitro and in murine bone marrow cells in vivo. A slight but consistent increase in SCE was observed in both biological systems.
Subject(s)
Anisoles/toxicity , Anticholesteremic Agents/toxicity , Bone Marrow/drug effects , Lymphocytes/drug effects , Mutagenesis , Plants, Medicinal , Sister Chromatid Exchange , Allylbenzene Derivatives , Animals , Bone Marrow Cells , Cell Division/drug effects , Cells, Cultured , Chi-Square Distribution , DNA Replication/drug effects , Humans , Least-Squares Analysis , Lethal Dose 50 , Male , Mexico , Mice , Mice, Inbred BALB C , Mitotic Index/drug effectsABSTRACT
PIP: An analysis of age at menarche in Mexico is presented. Data concern 1,500 girls in the urban population of Leon. Consideration is given to differences by socioeconomic status, height, and weight. (summary in ENG)^ieng
Subject(s)
Body Height , Body Weight , Menarche , Adipose Tissue , Adolescent , Body Water/analysis , Child , Data Collection , Female , HumansSubject(s)
Poliomyelitis/transmission , Cuba , Feces/microbiology , Female , Humans , Infant , Infant, Newborn , Male , Poliomyelitis/microbiology , Poliovirus/isolation & purificationABSTRACT
A nutritional inquest was carried out in 1857 children attending kindergartens in Córdoba, Argentina, in 1974. Determinations were made for the socioeconomical level each child belonged (NES) and clinical and anthropometric examinations. Nutritional inquests were carried out in 414 of these children, psychological examinations in 51, and biochemical inquests in 61 children.