Subject(s)
Aminoquinolines/therapeutic use , Bowen's Disease/drug therapy , Fluorouracil/therapeutic use , Neoplasms, Radiation-Induced/drug therapy , Nicotinic Acids/therapeutic use , Skin Neoplasms/drug therapy , Aminoquinolines/administration & dosage , Antineoplastic Agents/administration & dosage , Antineoplastic Agents/therapeutic use , Biopsy , Bowen's Disease/etiology , Bowen's Disease/pathology , Dermatologic Agents/administration & dosage , Dermatologic Agents/therapeutic use , Dose-Response Relationship, Drug , Drug Administration Routes , Drug Therapy, Combination , Fluorouracil/administration & dosage , Follow-Up Studies , Hand , Humans , Imiquimod , Male , Middle Aged , Neoplasms, Radiation-Induced/pathology , Nicotinic Acids/administration & dosage , Skin Neoplasms/etiology , Skin Neoplasms/pathologyABSTRACT
The immune response modulator, imiquimod, has a wide ranging utility in dermatology. Some rare adverse events are easily explained based upon its mechanism of action (such as induction of vitiligo and worsening of psoriasis). We report the occurrence of cutaneous vasodilatory side effects, angioedema and urticaria, which accompanied the treatment of basal cell carcinomas in two patients. These phenomena must be quite rare considering a paucity of similar reports in the literature.
Subject(s)
Adjuvants, Immunologic/adverse effects , Aminoquinolines/adverse effects , Angioedema/chemically induced , Antineoplastic Agents/adverse effects , Urticaria/chemically induced , Adjuvants, Immunologic/administration & dosage , Administration, Cutaneous , Aminoquinolines/administration & dosage , Antineoplastic Agents/administration & dosage , Carcinoma, Basal Cell/drug therapy , Female , Humans , Imiquimod , Male , Middle Aged , Skin/pathology , Skin Neoplasms/drug therapyABSTRACT
A simple maneuver is presented which simultaneously facilitates both adequate surgical site exposure and sufficient traction. A single suture with high tensile strength can be utilized to this end. This technique is especially helpful when the cutaneous surgeon is operating alone.
Subject(s)
Dermatologic Surgical Procedures , Dermatology/methods , Ear Auricle/surgery , Ear Neoplasms/surgery , Skin Neoplasms/surgery , Humans , Suture Techniques , SuturesSubject(s)
Epidermal Cyst/diagnosis , Foreign-Body Reaction/diagnosis , Hair Diseases/diagnosis , Aged , Diagnosis, Differential , Humans , MaleABSTRACT
Tungiasis is a cutaneous infestation caused by the burrowing flea, Tunga penetrans. This infection typically results in the development of one or more wart-like fibrous papulonodules. The causative flea is endogenous to Central and South America, sub-Sarahan Africa and portions of India; consequently, tungiasis is rarely reported in North America. However, because of increasing air travel to and from endemic areas due to business and pleasure, it is imperative that this entity remain in the differential diagnosis when evaluating clinically suggestive lesions in a patient who also has a history of recent travel. We report a case of tungiasis in a 24-year-old Caucasian woman who presented with 7-week history of a non-healing, eroded nodule on the medial aspect of her left great toe. Significant history included travel to Tanzania during three months immediately prior to presentation. Following the presumptive clinical diagnosis of tungiasis, surgical removal of the flea and its contents was performed and the base of the lesion was curetted, without complication. The specimen was sent for histopathologic correlation which confirmed the diagnosis.
