1.
Org Biomol Chem
; 10(5): 1088-92, 2012 Feb 07.
Article
in English
| MEDLINE
| ID: mdl-22179680
ABSTRACT
We describe the synthesis and coordination behaviour to copper(II) of two close structural triazacyclophane-based mimics of two often encountered aspartic acid and histidine containing metalloenzyme active sites. Coordination of these mimics to copper(I) and their reaction with molecular oxygen leads to the formation of dimeric bis(µ-hydroxo) dicopper(II) complexes.
Subject(s)
Aspartic Acid/chemistry , Aza Compounds/chemistry , Biomimetic Materials/chemistry , Copper/chemistry , Heterocyclic Compounds, 2-Ring/chemistry , Histidine/chemistry , Metalloproteins/chemistry , Aspartic Acid/metabolism , Aza Compounds/metabolism , Biomimetic Materials/metabolism , Catalytic Domain , Coordination Complexes/chemistry , Coordination Complexes/metabolism , Copper/metabolism , Heterocyclic Compounds, 2-Ring/metabolism , Histidine/metabolism , Metalloproteins/metabolism , Oxygen/metabolism
2.
Chem Commun (Camb)
; (36): 4581-3, 2005 Sep 28.
Article
in English
| MEDLINE
| ID: mdl-16158121
ABSTRACT
Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%.
