ABSTRACT
Paraneoplastic cerebellar degeneration (PCD) is a rare disorder that is associated with lung or gynecological malignancies and Hodgkin lymphoma. Neurologic symptoms are commonly the initial presenting sign leading to the diagnosis of an underlying malignancy. We are presenting an Asian male with progressive lower extremity weakness with EBV-positive nasopharyngeal carcinoma (NPC) and anti-Yo antibodies. Peculiarly, transient diffuse leptomeningeal enhancement is seen on MR imaging. This is the first report of PCD associated with NPC and thus illustrates that PCD embodies a boarder set of disease than previously described.
Subject(s)
Nasopharyngeal Carcinoma/diagnostic imaging , Nasopharyngeal Neoplasms/diagnostic imaging , Paraneoplastic Cerebellar Degeneration/diagnostic imaging , Humans , Male , Middle Aged , Nasopharyngeal Carcinoma/complications , Nasopharyngeal Carcinoma/therapy , Nasopharyngeal Neoplasms/complications , Nasopharyngeal Neoplasms/therapy , Paraneoplastic Cerebellar Degeneration/complications , Paraneoplastic Cerebellar Degeneration/therapyABSTRACT
A MRI of the lumbal spine was performed on a patient with lumbago. Besides the fact of no evidence for a myelopathy caused by a herniated disc a both-sided iliac vein thrombosis could be seen. In further examination the coincidence of a congenital absence of vena cava inferior with distinctive collateral vessel systems over lumbal and spinal veins and heterozygosis for Factor V Leiden abnormality could be identified as cause for thrombosis. It is very likely that symptoms developed as a result of spinal vein hyperplasia and consecutive myelon compression.
