ABSTRACT
The case of a 66-year-old female patient with late diagnosis of giant anal canal mucinous adenocarcinoma invading the gluteal and vulvar regions is reported. Because of the patient's severe clinical status and disease morbidity, surgical resection of the lesion was accomplished, with no adjuvant chemo- or radiotherapy. In the postoperative period, the patient received hyperbaric oxygen therapy, which facilitated and even accelerated local healing. Total closure of the raw flesh area was achieved, with no recurrence signals of cancer being detected after one-year follow-up. We are convinced that, in this difficult case, hyperbaric oxygen therapy played a crucial role in patient recovery and wound healing, allowing for early closure with good progression.
Subject(s)
Adenocarcinoma, Mucinous/therapy , Anus Neoplasms/therapy , Hyperbaric Oxygenation/methods , Adenocarcinoma, Mucinous/pathology , Adenocarcinoma, Mucinous/surgery , Aged , Anal Canal/pathology , Anus Neoplasms/pathology , Anus Neoplasms/surgery , Buttocks/pathology , Combined Modality Therapy/methods , Female , Humans , Neoplasm Invasiveness/pathology , Perineum/pathology , Tumor Burden , Vaginal Neoplasms/pathology , Vaginal Neoplasms/therapyABSTRACT
This is a study of 3 cases of the Laurence-Moon-Bardet-Biedl syndrome in two families. In one family the parents were consaguineous (first cousins). The authors studied the main symptoms and insist on the importance of the ophthalmological manifestation. No hypophyseal involvement was observed in these cases.
Subject(s)
Laurence-Moon Syndrome/complications , Adolescent , Child , Chromosome Aberrations , Female , Fingers/abnormalities , Humans , Hypogonadism/complications , Laurence-Moon Syndrome/classification , Laurence-Moon Syndrome/genetics , Laurence-Moon Syndrome/pathology , Male , Mental Disorders/complications , Obesity/complications , Retinal Diseases/complications , Toes/abnormalitiesABSTRACT
Epidermal Growth Factor is a polypeptide isolated from mouse submaxillary glands and evaluated by histological studies. The healing of 7.3 mm diameter central corneal epithelial wounds after treatment with epidermal Growth Factor was measured by standardized photography. The results suggest that topically-administrated Epidermal Growth Factor, at a frequency of four (p less than 0.02) and six (p less than 0.001) times daily, significantly increases the corneal epithelial healing rate compared to the vehicle control. Histological examination of the control eyes enucleated after seven days of treatment showed an epithelium four to five layers in thickness. The basal cells had a round shape and round, centrally-positioned nuclei. The Epidermal Growth Factor treated group (six times daily) had an epithelial thickness of five to six layers. The basal cells were taller and more tightly-packed with oval nuclei oriented towards the apex of the cell.
Subject(s)
Cornea/drug effects , Epidermal Growth Factor/therapeutic use , Wound Healing/drug effects , Animals , Cornea/pathology , Corneal Ulcer/drug therapy , Corneal Ulcer/pathology , Disease Models, Animal , Epithelium/drug effects , Epithelium/pathology , Female , Male , Ophthalmic Solutions , RabbitsABSTRACT
E apresentado 1 caso de retinite por virus citomegalico (CMV), que se desenvolveu em um paciente submetido a transplante renal, em uso prolongado de terapia imunossupressiva. Os autores descrevem as caracteristicas da lesao e meios diagnosticos disponiveis, e chamam a atencao para a necessidade de um controle oftalmologico dos pacientes em uso prolongado de terapia imunossupressiva.
Subject(s)
Middle Aged , Humans , Male , Cytomegalovirus , Retinitis , Immunosuppressive AgentsABSTRACT
Sao apresentados 2 casos de uveite anterior aguda nao granulomatosa associada a espondilite anquilosante juvenil (EAJ). Os autores chamam atencao para a maior frequencia com que se vem relatando casos de EAJ,ressaltando o diagnostico diferencial entre esta afeccao e a artrite reumatoide juvenil no que respeita a oculopatia que pode acometer as 2 doencas. Ressaltam tambem a alta incidencia de uveite anterior aguda nao granulomatosa com a espondilite anquilosante, sua relacao com a tipagem positiva de antigenos HLA-B27, bem como a importancia do diagnostico precoce da EAJ, que muitas vezes pode ser auxiliado pelo oftalmologista. Os autores comentam,ainda, que o quadro ocular observado na EAJ, caracterizado por uma uveite anterior aguda nao granulomatosa, e em tudo semelhante ao que se verifica na espondilite anquilosante do adulto e naqueles casos em que o HLA-B27 e positivo mas nao ha comprometimento sistemico
Subject(s)
Adolescent , Humans , Male , Spondylitis, Ankylosing , Uveitis , HLA AntigensABSTRACT
Os autores relatam um caso de histiocitoma fibroso benigno na orbita, mostrando os aspectos clinicos e os achados histopatologicos da lesao. Com base na literatura chamam a atencao para a raridade do tumor e tecem comentarios sobre o diagnostico diferencial e o tratamenteo
Subject(s)
Orbital Neoplasms , Histiocytoma, Benign FibrousABSTRACT
Os autores descrevem 2 casos de uveite cronica anterior de achados semelhantes aos da artrite reumatoide juvenil, porem sem comprometimento articular ou sistemico. Embasados nos dados da literatura fazem o diagnostico de uveite cronica da adolescente e propoem para esta patologia o nome sindrome de Perkins, em homenagem ao autor que melhor estudou a doenca
