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Int J Biol Sci ; 15(5): 1072-1079, 2019.
Article in English | MEDLINE | ID: mdl-31182926

ABSTRACT

Epidermal growth factor receptor (EGFR), a cancer-driven gene, plays an important role in tumorigenesis of lung cancer. Cryptotanshinone (CT) is the main constituent of salia miltiorrhiza and has been found to affect tumor progression. However, the mechanism of CT on lung cancer is still not clear. Here we found that CT could suppress the proliferation of non-small cell lung cancer (NSCLC) by inhibiting EGFR. We further confirmed that knockdown of EGFR also suppressed cell proliferation and arrested cell cycle progression. Furthermore, we evaluated EGFR was a direct target gene of miR-146a-5p which was upregulated by CT. In general, our results proved that CT could restrain NSCLC via miR-146a-5p/EGFR axis. CT and miR-146a-5p have the potential to be positive candidates in drug development of NSCLC.


Subject(s)
Carcinoma, Non-Small-Cell Lung/metabolism , MicroRNAs/metabolism , Phenanthrenes/pharmacology , A549 Cells , Cell Cycle/drug effects , Cell Cycle/genetics , Cell Line, Tumor , Cell Proliferation/drug effects , Cell Proliferation/genetics , ErbB Receptors/metabolism , HEK293 Cells , Humans , Immunoblotting
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