Scalp blocks do not affect the accuracy of neuronavigation facial recognition registration.

PURPOSE: Scalp block is a regional anesthesia technique to reduce the sympathetic response to skull pin application and postoperative pain in patients undergoing craniotomy. These blocks are often performed prior to surgical incision, however, the effect that these blocks have on neuronavigation facial tracing recognition accuracy is unclear because they may distort facial anatomy. METHODS: A series of 25 patients undergoing supratentorial craniotomy were administered scalp blocks prior to surgical incision, and their effect on neuronavigation accuracy was assessed. Statistical analysis utilized a two-tailed matched t-test. RESULTS: Bilateral supraorbital and auriculotemporal scalp blocks did not significantly affect the accuracy of facial recognition registration. CONCLUSION: Scalp block does not interfere with neuronavigation facial recognition accuracy during neurosurgical procedures.

Comprehensive Study of HCN: Potential Energy Surfaces, State-to-State Kinetics, and Master Equation Analysis.

Understanding the kinetics of the HCN system is critical to several disciplines in science and engineering, including interstellar chemistry, atmospheric reentry, and combustion, to name a few. This paper constructs a rovibrational state-specific kinetic mechanism for the HCN system, leveraging electronic structure calculations, classical scattering dynamics, and state-to-state kinetics. To this aim, three accurate potential energy surfaces (PESs), 1A', 3A', and 3A″, are constructed using multireference configuration interaction (MRCI) calculations for a comprehensive arrangement of the nuclei. Quasi-classical scattering calculations provide elementary reaction rate constants resulting from the interaction between the CN, CH, and NH molecules with H, N, and C atoms, respectively. The rovibrational collisional model developed comprises 50 million bound-bound and free-bound collisional processes. This model is used to study the dynamics of energy transfer and dissociation in an isochoric and isothermal chemical reactor via the solution of the master equation for a wide temperature range from 1000 to 10,000 K. This study unravels the dynamics of dissociation of the molecules in the HCN system, which the PESs primarily control via the formation of short-lived intermediates that shortcut the dissociation pathway. The exchange processes in CH and NH enhance the dissociation by over 80%. The importance of exchange processes is also highlighted in comparing the quasi-steady state and thermal dissociation rates with state-of-the-art rate models and experimental fits.

Carbon Clusters: Thermochemistry and Electronic Structure at High Temperatures.

This paper studies the thermochemistry and electronic structure of small carbon clusters and hydrocarbons, which are major constituents of pyrolysis gases released into the boundary layer of ablating heat shields. Our focus lies on clusters of up to four carbon atoms. Among other molecules, thermochemistry data for molecules such as C3H and C4H have been determined using the Weizmann-1 (W1) method. These molecules have very limited thermochemistry data recorded in the literature, thereby necessitating new and accurate computations of required properties such as electronic energies of low-lying states, heats of formation, harmonic frequencies, and rotational constants. A study of electronically excited states of these molecules computed using the equations of motion coupled cluster singles doubles method revealed C4 and C4H to be potential sources of radiation absorption in the boundary layer. The excited electronic states of interest are studied further to obtain their optimum geometries, rotational constants, and vibrational frequencies. Moreover, we also study the effect of low-lying excited electronic states on the partition function to assess their effect on the thermodynamics of these pyrolysis gases in the high-temperature regime. Neglecting the excited electronic states records a maximum difference of 12% in the computed specific heat capacity values, Cp values. Finally, comparisons of the equilibrium mole fractions obtained using the thermodynamics computed in this paper with the existing state-of-the-art tables used for hypersonic applications (e.g., JANAF and Gurvich Tables) show an order of magnitude difference in the mixture compositions. It is shown that the rhombic isomer of C4 (1Ag), which is energetically close to the ground state (3Σg-) and usually neglected in composition calculations, contributes to a 28% increase in the equilibrium mole fraction of the C4 molecule.

Rapid Blood Transfusion: The Importance of Hemodilution and Needleless Connectors.

INTRODUCTION:  Large-bore cannulas are critical to administering IV fluids and blood products during resuscitation and treatment of hemorrhage. Although catheter flow rates for crystalloid solutions are well defined, rapid administration of blood products is poorly characterized. In this in vitro study, we examined the effects of hemodilution and needleless connectors on red blood cell (RBC) flow rates. METHODS:  To determine RBC flow rates through large-bore cannulae, a crystalloid solution (Normosol®, Hospira, Lake Forest, IL) or RBC units were warmed and delivered under pressure (360 mmHg) using a Level 1 H-1200 Fast Flow Fluid Warmer (Smiths Medical, St. Paul, MN). Flow rates for crystalloid, packed RBCs and diluted RBCs were determined using a stopwatch. Additionally, the effect of the MaxPlus® clear needleless connector (CareFusion, San Diego, CA) was measured in all three infusion groups. RESULTS:  Flow rates for undiluted RBC units were 53% slower than crystalloid solution (220 mL/min vs. 463 mL/min; p=0.0003), however, when RBC units were diluted to a hematocrit of ~30% flow rate improved to 369 mL/min (p=0.005). The addition of the MaxPlus® needleless connector reduced flow of crystalloid solution by 47% (245 mL/min; p=0.0001), undiluted RBCs by 64% (78 mL/min; p=0.01), and diluted RBCs by 51% (180 mL/min; p=0.00003). Compared to undiluted RBC units, hemodilution increased RBC delivery rate through a MaxPlus® connector by 130% (p=0.004) and by 68% (p=0.02) when the catheter was directly connected to the Level 1 tubing (MaxPlus® excluded). CONCLUSION:  In settings requiring rapid transfusion of RBC units, needleless connectors should not be used and hemodilution should be considered in order to decrease the time required to deliver an equivalent red cell mass.

Management of brain tumors presenting in pregnancy: a case series and systematic review.

Patients who present with brain tumors during pregnancy require unique imaging and neurosurgical, obstetrical, and anesthetic considerations. Here, we review the literature and discuss the management of patients who present with brain tumors during pregnancy. Between 2009 and 2019, 9 patients were diagnosed at our institution with brain tumors during pregnancy. Clinical information was extracted from the electronic medical records. The median age at presentation was 29 years (range, 25-38 years). The most common symptoms at presentation included headache (n=5), visual changes (n=4), hemiparesis (n=3), and seizures (n=3). The median gestational age at presentation was 20.5 weeks (range, 11-37 weeks). Of note, 8 patients (89%) delivered healthy newborns, and 1 patient terminated her pregnancy. In addition, 5 patients (56%) required neurosurgical procedures during pregnancy (gestational ages, 14-37 weeks) because of disease progression (n=2) or neurologic instability (n=3). There was 1 episode of postneurosurgery morbidity (pulmonary embolism [PE]) and no surgical maternal mortality. The median length of follow-up was 15 months (range, 6-45 months). In cases demonstrating unstable or progressive neurosurgical status past the point of fetal viability, neurosurgical intervention should be considered. The physiological and pharmacodynamic changes of pregnancy substantially affect anesthetic management. Pregnancy termination should be discussed and offered to the patient when aggressive disease necessitates immediate treatment and the fetal gestational age remains previable, although neurologically stable patients may be able to continue the pregnancy to term. Ultimately, pregnant patients with brain tumors require an individualized approach to their care under the guidance of a multidisciplinary team.

Intraoperative Transcranial Motor-evoked Potential Stimulation Does Not Seem to Cause Seizures.

BACKGROUND: Intraoperative neurophysiological monitoring is of critical importance in evaluating the functional integrity of the central nervous system during surgery of the central or peripheral nervous system. In a large recent study, transcranial motor-evoked potentials (TcMEPs) were found to be associated with a 0.7% risk of inducing a seizure as diagnosed by clinical observation and electromyography in patients having general anesthesia with intravenous anesthetics. The gold standard for seizure diagnosis, however, is electroencephalography (EEG). The aim of this single-institution retrospective study is to ascertain the risk of intraoperative seizures detected using EEG during surgeries in adult patients undergoing intraoperative monitoring with TcMEPs. METHODS: The authors retrospectively reviewed the intraoperative EEG records of 1175 patients anesthetized with a variety of anesthetic agents, including volatile and intravenous anesthetics, to ascertain the rate of EEG-diagnosed seizures attributable to TcMEPs. RESULT: Our analysis did not reveal a single seizure event attributable to TcMEPs in 1175 patients. CONCLUSION: The intraoperative use of TcMEPs does not seem to cause seizures.

Feasibility study of a smartphone pupillometer and evaluation of its accuracy.

Measurement of pupillary characteristics, such as pupillary unrest in ambient light, and reflex dilation have been shown to be useful in a variety of clinical situations. Dedicated pupillometers typically capture images in the near-infrared to allow imaging in both light and darkness. However, because a subset of pupillary measurements can be acquired with levels of visible light suitable for conventional cameras, it is theoretically possible to capture data using general purpose cameras and computing devices such as those found on smartphones. Here we describe the development of a smartphone-based pupillometer and compare its performance with a commercial pupillometer. Smartphone pupillometry software was developed and then compared with a commercial pupillometer by performing simultaneous scans in both eyes, using the smartphone pupillometer and a commercial pupillometer. The raw scans were compared, as well as a selected pupillary index: pupillary unrest in ambient light. In 77% of the scans the software was able to successfully identify the pupil and iris. The raw data as well as calculated values of pupillary unrest in ambient light were in clinically acceptable levels of agreement; Bland-Altman analysis of raw pupil measurements yielded a 95% confidence interval of 0.26 mm. In certain situations a smartphone pupillometer may be an appropriate alternative to a commercial pupillometer.

100% Nitrous Oxide in the Oxygen Line: How Could This Happen in a Modern Anesthesia Machine?

The inadvertent crossover between O2 and N2O pipelines has become extremely rare in practice. We describe a case where it was possible to ventilate with 100% N2O instead of the intended 100% O2 on a modern anesthesia delivery system (Dräger Apollo; Drägerwerk AG & Co KgaA, Lübeck, Germany). This was the result of the incorrect assembly of diameter index safety system (DISS) components during preventative maintenance that defeated the DISS failsafe system. To make incorrect assembly easier to avoid, DISS component labeling could be more prominent and color-coded, or the internal construction of the gas manifold could incorporate DISS.

Plasma nitrite as an indicator of cerebral ischemia during extracranial/intracranial bypass surgery in moyamoya patients.

BACKGROUND AND PURPOSE: Nitric oxide (NO) plays a key role in ischemia and shows potential as a biomarker for ischemia. We measured mixed venous nitrite (NO2-) as a proxy for NO, during controlled cerebral ischemia in patients with moyamoya disease (MMD) during direct extracranial/intracranial (EC/IC) bypass surgery with temporary occlusion of the M4 branch of the middle cerebral artery (MCA) to permit anastomosis with the superficial temporal artery (STA). This small, focal ischemic event is not reliably detected using cerebral oximetry, somatosensory evoked potentials (SSEPs) or electroencephalography (EEG). METHODS: We enrolled nine adult MMD patients (n=8 female, n=1 male) undergoing direct EC/IC bypass surgery. Nitrite was measured at least one hour prior to MCA occlusion, and before, during and after anastomosis. Cortical function was monitored using either multi-lead EEG and SSEPs, or frontal EEG activity. RESULTS: Mixed venous NO2- was significantly elevated (p<0.05) within 12 min following arterial occlusion vs. baseline. An M4 branch of the MCA was cross clamped for a median duration of 18 (IQR = 5) minutes during anastomosis. One patient with elevated NO2- showed a transient neurologic deficit that resolved 3 days post-operatively. CONCLUSIONS: Mixed venous NO2- was significantly elevated shortly following cerebral artery occlusion vs. baseline in a majority of the study subjects, suggesting that NO2- is a potential biomarker for ischemia. Since all patients received identical burst suppression anesthesia and vasopressors, the fact that NO2- was not elevated during cross-clamp in all patients supports the conclusion that the NO2- elevation is likely due to ischemia.

Paradoxical Critical Hyperkalemia After Acetazolamide for Cerebrovascular Reactivity Study: A Case Report.

We present the case of a 42-year-old man with moyamoya disease presenting for cerebral revascularization surgery who developed critical hyperkalemia following a single intravenous (iv) dose of 1000 mg of acetazolamide 1 day preoperatively for a cerebrovascular reactivity study. His potassium increased from 5.1 to 6.7 mmol/L. Prompt treatment of this abnormality allowed this patient to undergo surgery the next day uneventfully. A paradoxical, critical increase in potassium can result from a single 1000-mg iv dose of acetazolamide.

An Anesthesia Attempt to Be Green: How Do You Waste Your Carbon Dioxide Absorbers?

Operating room waste is categorized as noncontaminated solid waste (SW) and regulated medical waste (RMW). RMW is treated by autoclaving at an increased economic and environmental cost. We evaluated these costs with a focus on the disposable carbon dioxide (CO2) absorbers. At our institution, exhausted CO2 absorbers were discarded as RMW. We collaborated with product representatives, anesthesia and perioperative staff, and waste management personnel to identify opportunities and barriers for recycling and waste reduction. Ultimately, we agreed to discard CO2 absorbers as SW instead of RMW, a strategy that is practical, less expensive, and more environmentally appropriate.

Acetaminophen Does Not Reduce Postoperative Opiate Consumption in Patients Undergoing Craniotomy for Cerebral Revascularization: A Randomized Control Trial.

Background Postoperative management in patients undergoing craniotomy is unique and challenging. We utilized a population of patients who underwent bilateral extracranial-to-intracranial (EC-IC bypass) revascularization procedures for moyamoya disease and hypothesized that 1 gram (gm) of intravenous (IV) acetaminophen given immediately after intubation and again 45 minutes prior to the end of craniotomy may be more effective than saline in minimizing opiate consumption and decreasing pain scores. Methods In a double-blind, randomized, placebo-controlled crossover pilot study, 40 craniotomies in 20 patients were studied. A random number generator assigned patients to receive either 1 gram of IV acetaminophen or an equal volume of normal saline immediately after intubation and again 45 minutes prior to the end of their first operation. For the second surgery, patients received the study drug (IV acetaminophen or normal saline) that they did not receive during their first surgery. Results In the IV acetaminophen group, the average 24-hour postoperative fentanyl equivalent consumption was decreased but the difference was not statistically significant: 228 micrograms compared to 312 micrograms in the placebo group (Figure 1; p = 0.09). Pain scores did not significantly differ between the IV acetaminophen group and the placebo group in postoperative hours 0-12 (Figure 2; p = 0.44) or 24 (Figure 3; p = 0.77). Conclusion Our study demonstrates that in patients receiving bilateral craniotomies for moyamoya disease, IV acetaminophen when given immediately after intubation and again 45 minutes prior to closure does not significantly decrease 12- or 24-hour postoperative opiate consumption.