ABSTRACT
Temporary occlusion of the left renal artery for 0-180 min after contralateral nephrectomy was undertaken in 51 rabbits. The correlation between the injury of warm ischaemia and kidney function, survival and histology was evaluated. After 0, 60, 90 and 120 min occlusion, all animals survived and normal renal function was restored. After occlusion for 150 min only 4 of 10 animals survived, and normal renal function was not re-established. 180 min occlusion was detrimental to the animals. Only one out of ten survived with severely damaged kidney function. Histological findings were consistent with the experimental observations of renal function.
Subject(s)
Ischemia , Kidney/blood supply , Animals , Blood Pressure , Creatinine/blood , Female , Ischemia/pathology , Kidney/pathology , Kidney/physiopathology , Nephrectomy , Rabbits , Renal Artery/surgery , Time FactorsABSTRACT
The influence of chlorpromazine and heparin pretreament on kidney function and histology has been investigated in rabbit kidneys damaged by warm ischaemia. Three experimental groups were investigated. One in which animals were pretreated with heparin, one group pretreated with heparin and chlorpromazine, and one group without pretreatment. The left renal artery was temporarily clamped for 3 hours and the kidneys recirculated. After 2-3 weeks a delayed contralateral nephrectomy was made, and after another 2-3 weeks all kidneys were studied histologically. Kidney function was measured by determination of serum-creatinine. The experiments showed, that all animals survived with impaired renal function. Pretreatment with chlorpromazine and heparin did not affect the final results. Secerity of the ischaemic damage, histologically evaluated was the same in all groups.
Subject(s)
Chlorpromazine/pharmacology , Heparin/pharmacology , Ischemia/physiopathology , Kidney/blood supply , Animals , Creatinine/blood , Female , Kidney/drug effects , Kidney/physiopathology , Nephrectomy , Rabbits , Renal Artery/surgeryABSTRACT
The influence of chlorpromazine pretreatment on kidney function and survival after temporary occlusion of the renal artery was investigated. Three hours of clamping of the renal artery and contralateral nephrectomy was performed in a group of ten rabbits pretreated with 3.5 mg/kg chlorpromazine and compared with a previously published control group of untreated animals. Chlorpromazine pretreatment improved survival. The kidney function, estimated by serum-creatinine, showed an earlier onset of function and the surviving animals regained nearly normal function. Histological examination revealed mild to moderate ischaemic changes, whereas the control group showed more profound damages.
