Zinc Ortho Methyl Carbonodithioate Improved Pre and Post-Synapse Memory Impairment via SIRT1/p-JNK Pathway against Scopolamine in Adult Mice.

Alzheimer's disease (AD) is globally recognized as a prominent cause of dementia for which efficient treatment is still lacking. New candidate compounds that are biologically potent are regularly tested. We, therefore, hypothesized to study the neuroprotective potential of Zinc Ortho Methyl Carbonodithioate (thereafter called ZOMEC) against Scopolamine (SCOP) induced Alzheimer's disease (AD) model using adult albino mice. We post-administered ZOMEC (30 mg/Kg) into two group of mice for three weeks on daily basis that received either 0.9% saline or SCOP (1 mg/Kg) for initial two weeks. The other two groups of mice received 0.9% saline and SCOP (1 mg/Kg) respectively. After memory related behavioral analysis the brain homogenates were evaluated for the antioxidant potential of ZOMEC and multiple protein markers were examined through western blotting. Our results provide enough evidences that ZOMEC decrease oxidative stress by increasing catalase (CAT) and glutathione S transferase (GST) and decreasing the lipid peroxidation (LPO). The SIRT1 and pre and post synaptic marker proteins, synaptophysin (SYP) as well as post synaptic density protein (PSD-95) expression were also enhanced upon ZOMEC treatment. Furthermore, memory impairment was rescued and ZOMEC appreciably abrogated the Aß accumulation, BACE1 expression C and the p-JNK pathway. The inflammatory protein markers, NF-kß and IL-1ß in ZOMEC treated mice were also comparable with control group. The predicted interaction of ZOMEC with SIRT1 was further confirmed by molecular docking. These findings thus provide initial reports on efficacy of ZOMEC in SCOP induced AD model.

Knowledge, attitude, and practice towards blood donation among residential students and teachers of religious institutions in Bangladesh - A cross-sectional study.

The availability of voluntary nonremunerated blood donors is a major concern in low- and middle-income countries because there is a substantial scarcity of safe blood supply against the expected demand. This study explores the status of knowledge, attitude, and practice regarding blood donation among students and teachers of residential religious academic institutions in Jamalpur district in Bangladesh. Religious institutions were selected through simple random sampling, and the cross-sectional survey included 512 participants. Descriptive and inferential statistics were performed with statistical significance defined as p < 0.05. Over 90% of the participants were students, non-smokers, and aged 18-30 years. The majority (92%) did not ever donate blood to anyone, yet over 42% wanted to be regular donors. More than 80% considered blood donation a moral responsibility and an Islamic act. The common reasons for not donating blood were lack of knowledge (40%), lack of opportunity (20%), thinking it was harmful to health (21%), fearing needles (16%), and no financial benefit (6%). Interestingly, more than 67% did not know their blood group, and about 61% of the respondents said they did not hear of or could not remember any blood donation program. The participants had poor knowledge of general eligibility criteria but an overall positive attitude towards blood donation. There was a weak positive correlation between knowledge, attitude, and practice scores. Participants willing to donate blood to strangers were four times more likely to do so regularly. Those who considered blood donation a religious act and a moral responsibility were twice as likely to become regular blood donors. This study reveals that many potential donors are being neglected, although they may be a valuable resource in addressing the ongoing blood donation issue.

ZOMEC via the p-Akt/Nrf2 Pathway Restored PTZ-Induced Oxidative Stress-Mediated Memory Dysfunction in Mouse Model.

A new mechanistic approach to overcome the neurodegenerative disorders caused by oxidative stress in Alzheimer's disease (AD) is highly stressed in this article. Thus, a newly formulated drug (zinc ortho-methyl carbonodithioate (ZOMEC)) was investigated for five weeks on seven-week-old BALB/c male mice. ZOMEC 30 mg/kg was postadministered intraperitoneally during the third week of pentylenetetrazole (PTZ) injection. The brain homogenates of the mice were evaluated for their antioxidant potential for ZOMEC. The results including catalase (CAT), glutathione S transferase (GST), and lipid peroxidation (LPO) demonstrated that ZOMEC significantly reverted the oxidative stress stimulated by PTZ in the mouse brain. ZOMEC upregulated p-Akt/Nrf-2 pathways (also supported by molecular docking methods) to revoke PTZ-induced apoptotic protein markers. ZOMEC reversed PTZ-induced neuronal synapse deficits, improved oxidative stress-aided memory impairment, and inhibited the amyloidogenic pathway in mouse brains. The results suggested the potential of ZOMEC as a new, safe, and neurotherapeutic agent to cure neurodegenerative disorders by decreasing AD-like neuropathology in the animal PTZ model.

A Cumulants-Based Human Brain Decoding.

Human cognition is influenced by the way the nervous system processes information and is linked to this mechanical explanation of the human body's cognitive function. Accuracy is the key emphasis in neuroscience which may be enhanced by utilising new hardware, mathematical, statistical, and computational methodologies. Feature extraction and feature selection also play a crucial function in gaining improved accuracy since the proper characteristics can identify brain states efficiently. However, both feature extraction and selection procedures are dependent on mathematical and statistical techniques which implies that mathematical and statistical techniques have a direct or indirect influence on prediction accuracy. The forthcoming challenges of the brain-computer interface necessitate a thorough critical understanding of the complicated structure and uncertain behavior of the brain. It is impossible to upgrade hardware periodically, and thus, an option is necessary to collect maximum information from the brain against varied actions. The mathematical and statistical combination could be the ideal answer for neuroscientists which can be utilised for feature extraction, feature selection, and classification. That is why in this research a statistical technique is offered together with specialised feature extraction and selection methods to increase the accuracy. A score fusion function is changed utilising an enhanced cumulants-driven likelihood ratio test employing multivariate pattern analysis. Functional MRI data were acquired from 12 patients versus a visual test that comprises of pictures from five distinct categories. After cleaning the data, feature extraction and selection were done using mathematical approaches, and lastly, the best match of the projected class was established using the likelihood ratio test. To validate the suggested approach, it is compared with the current methods reported in recent research.

Is Childhood Overweight/Obesity Perceived as a Health Problem by Mothers of Preschool Aged Children in Bangladesh? A Community Level Cross-Sectional Study.

Childhood obesity is rapidly rising in many developing countries such as Bangladesh; however, the factors responsible for this increase are not well understood. Being the primary caregivers of children, particularly in developing countries, maternal perceptions and knowledge could be important factors influencing the weight status of children. This study aimed to assess maternal perceptions of childhood obesity and associated socio-demographic factors in Bangladesh. A cross-sectional study using stratified random sampling was conducted among 585 mothers whose children aged 4 to 7 years attended preschools in a district town. Body Mass Index of the children was calculated and weight status categorized according to the Centers for Disease Control (CDC) criteria. Maternal perceptions were assessed using a self- or interviewer-administered questionnaire. Multinomial logistic regression was used to obtain crude and adjusted odds ratios. Fourteen percent of children were overweight or obese and approximately 30% were underweight. Only 3.1% of children were perceived as overweight/obese by their mothers. Over one-third (35%) of mothers perceived that childhood overweight/obesity could be a health problem and over two-thirds (68.6%) were not aware of any health consequences of childhood obesity. Maternal perceptions were significantly associated with maternal education, family income, and weight status of the child but were not associated with the sex of the child. We have identified knowledge gaps regarding maternal perception of childhood obesity and its contributing factors in a developing country. These findings can be used to develop and test parent-focused educational interventions for preventing childhood obesity in Bangladesh.

Melorheostosis with renal arterio-venous malformation: A case report with review of literature.

Melorheostosis, also known as Leri's disease and flowing periosteal hyperostosis, is a rare cause of pain and stiffness in a limb. The appearance is of "candle greasing" down one side of one or several bones of the body. We describe a case referred to tertiary care center with suspicion of renal cell carcinoma with diffuse bone metastasis. After reassessment, the patient was diagnosed melorheostosis with renal AV malformation. He was reassured about the benign nature of the disease and is asymptomatic.