Subject(s)
Education, Nursing, Continuing , Motivation , Nurses/psychology , Certification , Florida , Humans , Sampling Studies , Surveys and QuestionnairesSubject(s)
Antipsychotic Agents/metabolism , Bile/metabolism , Perazine/metabolism , Animals , Biotransformation , Common Bile Duct/physiology , Common Bile Duct/surgery , Fistula , Hydroxylation , Injections, Intravenous , Kinetics , Male , Perazine/administration & dosage , Portal Vein , Rats , Sulfur Radioisotopes , Tissue DistributionABSTRACT
N-[gamma-(2-Chlorophenothiazin-10-yl)propyl]ethylenediamine (Cl-PPED), a common metabolite of prochlorperazine and perphenazine, was orally administered to male rats at a dose of 50 mg/kg, and its concentrations in plasma, liver, lung, kidney, and brain were followed from 6 hr to 40 days after dosage. Small quantities were measured by two-dimensional thin-layer chromatography of a fluorescent derivative and in situ fluorometry of the chromatograms. The kinetic behavior of Cl-PPED in brain differed from that in other tissues in that the concentration maximum was achieved later and the elimination half-life was distinctly longer (8 days vs. 1.2-3 days). Cl-PPED was evenly among the three major brain regions. Subcellular fractionation of liver and brain revealed preferential localization in mitochondria.
