Comparative efficacy of flapped versus flapless dental implant procedures: A meta-analysis.

Objectives: Dental implant procedures are crucial for replacing missing teeth, with various surgical techniques impacting the outcome. This systematic review and meta-analysis aimed to evaluate the effects of flapped and flapless surgical techniques on implant survival and marginal bone loss (MBL). Methods: We included clinical studies with at least ten subjects, excluding review articles, editorials, and conference abstracts. Studies were sourced from PubMed, Medline, ERIC, and Wiley, published between 2000 and 2022. Data were analyzed using random-effects models to compare implant survival and MBL between flapped and flapless techniques. Results: The review identified 21 studies meeting the inclusion criteria. Flapless techniques showed a higher implant survival rate with an approximate survival rate of 98.6% in prospective cohort studies and 95.9% in retrospective studies. MBL was consistently lower in the flapless group, averaging 0.6-2.1 mm, compared to 1.5-3 mm in the flapped group. Low-risk studies demonstrated more consistent and reliable results, supporting the efficacy of flapless procedures. Conclusion: Flapless implant surgery offers a viable alternative to traditional flapped surgery, showing higher rates of implant survival and less MBL. However, successful outcomes depend on advanced imaging, precise surgical techniques, and adequate training. Further high-quality studies are needed to confirm these findings and refine clinical recommendations.

Melamine Exacerbates Neurotoxicity in D-Galactose-Induced Neuronal SH-SY5Y Cells.

Numerous studies have depicted the role of diet and environmental toxins in aging. Melamine (Mel) is a globally known notorious food adulterant, and its toxicity has been shown in several organs including the brain. However, till now, there are no reports regarding Mel neurotoxicity in aging neurons. So, this study examined the in vitro neurotoxicity caused by Mel in the D-galactose (DG)-induced aging model of neuronal SH-SY5Y cells. In the present study, the neuronal SH-SY5Y cells were treated with DG and Mel separately and in combination to assess the neurotoxicity potential using MTT assay and neurite length measurement. Further, the superoxide dismutase (SOD), catalase (CAT), and total antioxidant activities were evaluated followed by the determination of the intracellular reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and caspase3 (Casp3) activity. The cotreatment of Mel and DG in neuronal SH-SY5Y cells showed maximum cell death than the cells treated with DG or Mel individually and untreated control cells. The neurite length shrinkage and ROS production were maximum in the DG and Mel cotreated cells showing exacerbated toxicity of Mel. The activity of SOD, CAT, and total antioxidants was also found to be lowered in the cotreatment group (Mel + DG) than in Mel- or DG-treated and untreated cells. Further, the combined toxicity of Mel and DG also elevated the Casp3 activity more than any other group. This is the first study showing the increased neurotoxic potential of Mel in an aging model of neuronal SH-SY5Y cells which implicates that Mel consumption by the elderly may lead to increased incidences of neurodegeneration like Alzheimer's disease and Parkinson's disease.

Smoking cessation interventions in patients diagnosed with head and neck cancers: A systematic review of randomized controlled trials.

Objective: According to findings from the previous studies, quitting smoking can significantly reduce mortality from all causes and is linked to better treatment results. Even though quitting smoking has many benefits, little is known about the evidence supporting the particular quit services offered to smokers after a cancer diagnosis. Methods: To find the articles related to area in question, different electronic databases including PubMed/Medline, Google Scholar, and EBSCO were searched on April 1st, 2023. All full text randomized controlled trials with one or more intervention and control groups that assessed the outcomes of smoking cessation interventions were included. Participants of included studies were adults diagnosed with head and neck cancer (HNC) and current smokers or those who had recently quit. There were interventions (pharmacological and/or pharmacological) that aimed to help patients with HNC succeed in quitting smoking. Results: We identified 15352 papers from the initial search from different electronic databases, 2560 remained after excluding duplicates. After screening titles and abstracts for relevance, 2345 articles were removed. Full text articles of remaining 215 papers were assessed in depth by two reviewers for their eligibility, amongst which, 210 articles were excluded. Finally, we included five papers that met the inclusion criteria in the present systematic review. Conclusion: According to the findings of this review, a multi - component strategy might very well benefit patients with HNC who smoke cigarettes after diagnosis. More studies with high methodological quality and standardized outcome measures must be conducted in this population to inform the development of smoking cessation program.

Pathological tooth migration-spontaneous correction of diastema after surgical periodontal therapy: a case report.

A common consequence of moderate to extreme periodontitis is pathologic migration. This denotes tooth movement when the periodontal disease interjects the equilibrium among the elements that preserve physiological tooth position. The balancing factors can migrate the teeth in any direction. The etiology of pathological migration tends to be multifactorial, thus achieving early diagnosis is imperative, which will ultimately lead to the prompt removal of the etiological factors while avoiding severe bone destruction. In this case maxillary central incisors had diastema due to pathological migration with mobility grade I in maxillary left central incisor. Many cases of moderate to severe pathological migration need a suitable, interdisciplinary approach. Nevertheless, since it is possible to detect mild cases of Pathological tooth migration (PTM) at an early stage, spontaneous correction of migrated teeth can be accomplished by periodontal therapy alone. Regardless of the treatment selected, maintenance of stable results should be considered as an aim of treatment.

Mount Vernon Index vs Yen Angle for Assessment of Anteroposterior Apical Jaw Base Relationship.

AIMS AND OBJECTIVES: This research aimed to determine the predictability and variability of the Yen angle and Mount Vernon Index (MVI) in relation to the other four sagittal discrepancy parameters, as well as to evaluate and explain any correlations that exist. The Lateral Cephalograms of 100 Class I Indian participants aged 17-24 years were recorded. The lateral cephalograms were traced for six distinct AP characteristics, including ANB, Wits appraisal, facial convexity, and beta angle, Yen angle, and MVI. The gathered data were evaluated statistically using S.P.S.S. version 10. To determine the difference between males and females, an independent "t" test was used. The coefficient of variability and correlation methods were used to determine the correctness of the Yen angle and MVI, as well as the association between the variables. RESULTS: The results of this study indicate that the most predictable and highly dependable parameter was the Yen angle (CV = 5.63), followed by the beta angle (5.63), the MVI (CV = 13.6), the ANB, Rickett's analysis, and Wit's analysis. Throughout all five analyses, the most statistically significant positive association between the MVI and the BETA angle was determined. CONCLUSION: The derived inferences from the study included the high reliability of the yen angle for assessing the AP skeletal patterns of a patient, followed by the beta angle and MVI. HOW TO CITE THIS ARTICLE: Doshi JR, Jain P, Jain M, et al. Mount Vernon Index vs Yen Angle for Assessment of Anteroposterior Apical Jaw Base Relationship. Int J Clin Pediatr Dent 2021;14(S-1):S35-S38.

Chain dynamics and glass transition of dry native cellulose solutions in ionic liquids.

Dry native cellulose solutions in 1-butyl-3-methylimidazolium methylphosphonate (EMImMPO3H), 1-butyl-3-methylimidazolium acetate (EMImAc), and 1-butyl-3-methylimidazolium chloride (BMImCl) ionic liquids (IL) were investigated using subambient linear viscoelastic oscillatory shear. Glass transition temperatures (Tg) of solutions with various cellulose concentrations up to 8.0 wt% were observed as the peaks of loss tangent tan(δ) and loss modulus G'' in descending temperature sweeps at 1 rad s-1. Cellulose/IL solutions showed a minimum in Tg at ∼2.0 wt% cellulose content before increasing with cellulose concentration, suggesting a perturbation of the strongly structured IL solvents by the cellulose chains. Isothermal frequency sweeps in the vicinity of Tg were used to construct time-temperature-superposition master curves. The angular frequency shift factor aT as a function of temperature indicates Arrhenius behavior within a 9 K range near Tg, allowing calculation of fragility, which was found to be constant up to 8.0 wt% cellulose concentration. This result implied that increasing cellulose concentration initially decreases Tg due to disrupted ionic regularity of ILs, but does not seem to change their fragility.

Association of Neutral Zone Position with Age, Gender, and Period of Edentulism.

PURPOSE: The changing dynamics of an aging mouth influence the position of the neutral zone (NZ). While the advantage of the NZ concept in complete denture treatment is quite established, what is not clearly understood is its position in relation to the crest of the residual ridge due to conflicting reports from previous studies. The purpose of this study was to investigate the distance and direction of NZ position in relation to crest of the residual ridge in edentulous patients and its association with age, gender, and period of edentulism. MATERIALS AND METHODS: A cross-sectional study was conducted in 133 patients (70 males, 63 females) with a mean age of 58.81 ± 11.78 years. NZ recording was done using admix material by following standard procedures. Two metallic wires were adapted, one on the ridge and another on the center of the occlusal rims, and standardized digital radiographs were made. The position of NZ in relation to the crest of the residual ridge was recorded by noting the direction and measuring the distance between the adapted wires digitally at five locations (right molar, right premolar, incisor, left molar, left premolar regions). RESULTS: Age, gender, and period of edentulism had no significant association with the position of NZ. No specific trend was observed in the in NZ position with a non-significant correlation. CONCLUSIONS: Distance and the direction of neutral zone position in relation to crest of the residual ridge in edentulous patients bear no significant relationship with factors such as age, gender, and period of edentulism.

A Case-control Study for the Assessment of Correlation of Denture-related Sores and Oral Cancer Risk.

INTRODUCTION: Oral cancer is one of the most common cancers in the world. Although multifactorial, the exact pathogenesis of oral cancer is still unclear. Apart from tobacco chewing and smoking, chronic long-term irritation by ill-fitting denture is also said to be an important risk factor for the development of oral cancer. Literature quotes some amount of evidence that correlates long-term denture irritation as a risk factor for the development of oral cancer. Hence, we analyzed the correlation of denture-related sores as a risk factor for the development of oral cancer. MATERIALS AND METHODS: The present case-control study included 140 newly diagnosed oral cancer cases and 140 patients as the control healthy group. One-hour questionnaire was framed and was conducted to the control group and the study group by 10 experienced interviewers who were trained for such type of analysis. Assessment of the patients' socioeconomic status, cigarette smoking habit, alcohol drinking habit, and oral health status was done and compared on the two study groups. Logistic regression models along with multivariate models were used for the assessment of the results. RESULTS: In the control group and the cancer patient group, total of 140 new cancer cases and 140 subjects were included. Out of 140 patients in the cancer group, 16 were nonsmokers, while 110 smoked cigarette in the cancer patient group. As far as alcohol consumption is concerned, 42 patients in the control group and 102 patients in the oral cancer group were chronic heavy drinkers. Fried food intake was high in both the groups. Significant correlation was obtained while comparing the heavy smokers, heavy alcohol consumers, and oral health status in both the study groups. CONCLUSION: Our results favor the hypothesis that positive correlation exists between oral cancer risk and recurrent denture sores. CLINICAL SIGNIFICANCE: People wearing denture prosthesis should be periodically visualized for identification of any mucosal alteration or changes at the earliest.

Expression of Myofibroblasts in Oral Squamous Cell Carcinoma: An Immunohistochemical Study.

INTRODUCTION: Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancy affecting the orafacial region and with a high mortality rate. The fact that stroma of the tumor modulates and facilitates the progression and metastasis of the malignancy has been shown in the past studies. The cells of the activated stroma that are responsible for the progression and metastasis of the tumor are the fibroblasts having smooth muscle properties. These myofibroblasts are said to secrete numerous inflammatory mediators and factors which are said to play a crucial role in tumor progression. Therefore, we evaluated the presence of myofibroblasts in OSCC, by immunohisto-chemistry using alpha smooth muscle actin (a-SMA) antibody. MATERIALS AND METHODS: We evaluated a total of 50 biopsy specimens from the archives of the oral pathology, where 20 specimens out of 50 were of well-differentiated OSCC (WDOSCC), 20 were of poorly differentiated OSCC (PDOSCC), and 10 were of normal healthy controls. All the specimens were stained by immunohistochemically using with monoclonal antihuman α-SMA. Etemad-Moghadam et al method was used for assessing the myofibroblast distribution. Staining index was evaluated for the groups and compared. All the results were analyzed by Statistical Package for the Social Sciences (SPSS) software. RESULTS: The mean percentage of myofibroblasts score for WDOSCC and PDOSCC were 2.88 and 2.92 respectively. The mean staining intensity score in WDOSCC and PDOSCC were 2.88 and 2.55 respectively. Statistically significant results were obtained while comparing the final staining index score between the OSCC group and normal control group. No significant correlation could be obtained while comparing the mean staining index score in between WDOSCC and PDOSCC. CONCLUSION: Malignant epithelium might induce the adjacent stromal tissue to produce myofibroblasts. These specialized cells may be utilized as therapeutic targets for the treatment of OSCC. CLINICAL SIGNIFICANCE: Proliferation of myofibroblasts may be used as a stromal marker of premalignancy and malignancy.

Efficacy of xanthan based chlorhexidine gel as an adjunct to scaling and root planing in treatment of the chronic periodontitis.

AIM: The aim of this study was to evaluate the clinical effectiveness of locally delivered xanthan-based Chlosite(®) gel as an adjunctive therapy to scaling and root planing in treatment of chronic periodontitis. MATERIALS AND METHODS: In a randomized controlled clinical study, 30 patients were selected. Pocket depth between 5 and 7 mm was selected and each patient had two sites on the same side of the mouth. A total of 30 control sites were scaled and root planed and 30 test sites were scaled and root planed and Chlosite(®) gel was added. The clinical parameters, probing depth (PD), clinical attachment level (CAL), plaque index (PI) and bleeding on probing (BOP), gingival index were recorded at baseline, 6 weeks, 3 months and 6 months. STATISTICAL ANALYSIS: Paired/unpaired t-test was used, significance was placed at 5% level of significance, i.e., P < 0.05 was considered as a significant. RESULTS: From baseline to a period of 6 months, significant difference was found between test and control group for PD, CAL, PI and BOP, P value being PD (P = 0.002), CAL index (P = 0.014), respectively. CONCLUSION: Subgingival injection of xanthan-based Chlosite(®) gel adjunct with scaling and root planing appeared to cause significant improvement compared with scaling and root planing alone in persons with chronic periodontitis.

Modified bluegrass appliance: a nonpunitive therapy for thumb sucking in pediatric patients-a case report with review of the literature.

Oral habits in form of digit/thumb sucking are common phenomenon and part of childhood behavior. They are normally associated with oral pleasure, hunger, anxiety, and sometimes psychological disturbances. Chronic practice can cause major orthopedic alterations to the skeletal structures of the oral cavity and lower face. Aversive approaches in form of punitive therapy have been moderately effective. Modified bluegrass appliance is nonpunitive therapy to treat sucking habits. It acts as a habit reversal technique and installs positive reinforcement in children. Modified blue grass appliance proved to be very comfortable to patients and encourages neuromuscular stimulations.