ABSTRACT
Distribution of calcium and phosphorus was investigated with quantitative and qualitative methods in teeth of rats chronically treated with low doses of corticosteroids for 3 generations. In animals from 2nd and 3rd generation, scanning electron microscopy revealed focal lesions in enamel and dentin. The disturbances of the mineral metabolism in teeth of corticosteroid-treated rats were also reflected by abnormal calcium and phosphorus content in enamel and dentin, as assessed by X-ray microanalysis.
Subject(s)
Adrenal Cortex Hormones/toxicity , Calcium/metabolism , Phosphorus/metabolism , Prenatal Exposure Delayed Effects , Tooth/metabolism , Animals , Dental Enamel/drug effects , Dental Enamel/metabolism , Dentin/drug effects , Dentin/metabolism , Female , Male , Pregnancy , Rats , Rats, Wistar , Time Factors , Tissue Distribution , Tooth/drug effectsSubject(s)
Natal Teeth/ultrastructure , Tooth, Deciduous/ultrastructure , Female , Humans , Infant, Newborn , MaleSubject(s)
Dental Enamel/ultrastructure , Mucopolysaccharidosis IV/pathology , Child, Preschool , Dental Enamel/abnormalities , Dental Enamel/analysis , Electron Probe Microanalysis , Female , Humans , Microscopy, Electron, Scanning , Mucopolysaccharidosis IV/metabolism , Tooth, Deciduous/analysis , Tooth, Deciduous/ultrastructureABSTRACT
The experiments were carried out on Wistar rats with rickets experimentally induced. The following examinations were made: radiological examinations of the jaws, a teeth analysis in the microanalyser for the distribution of fundamental elements, and ultrastructure observations in the scanning electron microscope. The jaws of the experimental rats were smaller in the radiological picture. The disturbed arrangement of the enamel prisms was found in the enamel substructure of the experimental rats. Phosphorus values in the enamel and dentine were lower in the experimental animals. Calcium to phosphorus ratio was higher in the rachitic rats. Disturbances of calcium-phosphorus balance were observed.
