[Spinal mechanisms of neuroplasticity induced by neuromidin in treatment of traumatic neuropathies]. / Osobennosti spinal'nykh mekhanizmov neiroplastichnosti pri primenenii neiromidina v lechenii travmaticheskikh neiropatii.

AIM: To analyze the spinal mechanisms of neuroplastic changes induced by neuromidin (ipidacrine) in a model of traumatic axonotomy of the sciatic nerve in rats. MATERIAL AND METHODS: The histological study of the material from the anterior horn (lumbar portion of spinal cord) was performed in 6 rats using electron microscopy. RESULTS AND CONCLUSION: The comparative analysis of neuromorphological changes in rats of control and main groups revealed the neuroprotective and modifying effects of neuromidin on the spinal neuroplasticity.

[A comparative analysis of the efficacy of neuromidin and galantamine in Alzheimer's disease]. / Sravnitel'nyi analiz effektivnosti neiromidina i galantamina pri bolezni Al'tsgeimera.

OBJECTIVE: To evaluate the cognitive changes in patients with mild to moderate Alzheimer's disease after the treatment with acetylcholinesterase inhibitors - neuromidin and galantamine. MATERIAL AND METHODS: Fifty-eight patients with probable Alzheimer's disease, aged 60-84 years (mean 73.2±6.7), were enrolled in a 20-week double-blind parallel group study. All patients were randomized in 2 groups: group 1 (n=28) received neuromidin, group 2 (n=30) - galantamine. Treatment efficacy was evaluated with the ADAS-cog/11 scale. RESULTS: Both drugs significantly improved or stabilized cognitive function in the patients. The most marked changes were obtained in the group of patients treated with neuromidin (р<0.05). CONCLUSION: The results suggest that the effectiveness of anticholinesterase treatment of Alzheimer's disease could be determined not only by the central but also peripheral cholinergic action.