ABSTRACT
BACKGROUND: Childhood obesity is a global epidemic and is associated with a higher risk of chronic diseases such as hypertension, diabetes mellitus and other metabolic disorders. Several adipokines including resistin, visfatin, leptin and adiponectin are synthesized and secreted by adipocytes, which play an important role in obesity. PATIENTS & METHODS: A total of 90 subjects (60 controls and 30 obese) between the ages of 5 and 18 years were selected. Serum visfatin, TNF-α, resistin, insulin and adiponectin were measured using ELISA and insulin resistance was calculated by the Homeostasis Model of Assessment-Insulin Resistance. RESULTS: Mean ± standard deviation Homeostasis Model of Assessment-Insulin Resistance, serum TNF-α and visfatin levels were significantly higher in obese subjects (3.99 ± 0.94, 12.99 ± 3.42, 10.89 ± 2.72, respectively) compared with the control group (1.60 ± 0.34, 7.22 ± 2.22 and 4.97 ± 1.57, respectively). Mean ± standard deviation serum adiponectin levels were significantly lower in obese children (5.95 ± 1.02) compared with controls (9.07 ± 1.25). Binary logistic regression shows that adiponectin and visfatin are associated with obesity. CONCLUSION: Circulating levels of adipokines vary in obesity and adiponectin and visfatin are associated with obesity.
Subject(s)
Adipokines/blood , Obesity/blood , Adiponectin/blood , Adolescent , Blood Glucose/metabolism , Case-Control Studies , Child , Child, Preschool , Humans , Insulin/blood , Insulin Resistance , Male , Nicotinamide Phosphoribosyltransferase/blood , Obesity/complications , Resistin/blood , Tumor Necrosis Factor-alpha/bloodABSTRACT
OBJECTIVE OF THE STUDY: To investigate adipocytokines in patients with ischemic cerebrovascular disease and to develop an association between them. METHODS: In this study plasma adiponectin, leptin and Interleukin 6 (IL 6) concentration were measured by ELISA. Blood glucose and lipid profile was done by standard kit methods. RESULTS: A total of 80 subjects with and without CVD were studied. The mean plasma level of IL6 of the forty patients with ischemic CVD was significantly higher than that of the forty subjects without CVD (41.64 + 2.50 versus 22.76 + 0.76 pg/mL; P < 0.001). The mean plasma level of adiponectin was significantly lower in patients with ischemic CVD than that of subjects without CVD (4.36 +/- 0.21 microg/mL versus 6.9 +/-0.241microg/mL; P < 0.001). Serum leptin concentrations were significantly higher (p < 0.001) in stroke patients (51.61 + 1.39) as compared with controls (37.76 + 1.207). Leptin levels were significantly negatively correlated with adiponectin (P < 0.01) and significantly positively correlated (P < 0.01) with interleukin 6 in stroke patients. CONCLUSION: Present report provides additional support to the evidence of involvement of cytokines in inflammatory immune response of patients with cerebrovascular disease.
Subject(s)
Brain Ischemia/immunology , Cerebrovascular Disorders/immunology , Interleukin-6/immunology , Leptin/immunology , Adiponectin/blood , Adiponectin/immunology , Aged , Brain Ischemia/metabolism , Cerebrovascular Disorders/metabolism , Female , Humans , Inflammation/immunology , Inflammation/metabolism , Interleukin-6/blood , Leptin/blood , Male , Middle Aged , Stroke/immunology , Stroke/metabolismABSTRACT
We report a case of a rare disorder of renal amyloidosis occurring as a complication of juvenile rheumatoid arthritis in a 16-year-old adolescent male. He presented with generalized edema and hypertension. The laboratory work-up showed nephrotic-range proteinuria and hypoalbuminemia and normal renal function despite bilateral shrunken kidneys revealed by the abdominal ultrasound. His renal biopsy showed deposition of amyloid fibrils in the form of homogenous eosinophilic material within the glomeruli demonstrating the pathognomonic apple-green birefringence by polarized light microscopy.
