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1.
J Neurosurg Case Lessons ; 4(22)2022 Nov 28.
Article in English | MEDLINE | ID: mdl-36443955

ABSTRACT

BACKGROUND: Rasmussen encephalitis is a rare chronic neurological pathology frequently treated with functional hemispherectomy (or hemispherotomy). This surgical procedure frees patients of their severe epilepsy associated with the disease but may induce cognitive disorders and notably language alterations after disconnection of the left hemisphere. OBSERVATIONS: The authors describe longitudinally 3 cases of female patients with Rasmussen encephalitis who underwent left hemispherotomy in childhood and benefited from a favorable cognitive outcome. In the first patient, the hemispherotomy occurred at a young age, and the recovery of language and cognitive abilities was rapid and efficient. The second patient benefited from the surgery later in childhood. In addition, she presented a reorganization of language and memory functions that seem to have been at the expense of nonverbal ones. The third patient was a teenager during surgery. She benefited from a more partial cognitive recovery with persistent disorders several years after the surgery. LESSONS: Recovery of cognitive functions, including language, occurs after left hemispherotomy, even when performed late in childhood. Therefore, the surgery should be considered as early as possible to promote intercognitive reorganization.

2.
Epilepsy Behav ; 134: 108821, 2022 09.
Article in English | MEDLINE | ID: mdl-35868157

ABSTRACT

Functional hemispherectomy results in good outcomes in cases of refractory epilepsy and constitutes a unique situation in which to study cerebral plasticity and the reorganization of lateralized functions of the brain, especially in cases of infancy or childhood surgery. Previous studies have highlighted the remarkable ability of the brain to recover language after left hemispherectomy. This leads to a reorganization of language networks toward right hemisphere, causing limitation in the development of visuo-spatial abilities, known as a crowding effect in the right hemisphere. Deficits in nonverbal functions have also been described as a more direct consequence of right hemipherectomy, but the results from case studies have sometimes been contradictory. We conducted a group study which may effectively compare patients with left and right hemispherectomy and address the effects of the age of seizure onset and surgery. We analyzed the general visuo-spatial and visuo-perceptive abilities, including face and emotional facial expression processing, in a group of 40 patients aged 7-16 years with left (n = 24) or right (n = 16) functional hemispherectomy. Although the groups did not differ, on average, in general visuo-spatial and visuo-perceptive skills, patients with right hemispherectomy were more impaired in the processing of faces and emotional facial expressions compared with patients with left hemispherectomy. This may reflect a specific deficit in the perceptual processing of faces after right hemispherectomy. Results are discussed in terms of limited plasticity of the left hemisphere for facial and configural processing.


Subject(s)
Drug Resistant Epilepsy , Hemispherectomy , Child , Functional Laterality , Humans , Language , Seizures
3.
Handb Clin Neurol ; 174: 93-110, 2020.
Article in English | MEDLINE | ID: mdl-32977899

ABSTRACT

Since the seminal work on the patient HM, who in his adulthood presented an acquired amnesic syndrome following the resection of the bilateral temporal lobe, other research has described several cases of isolated memory dysfunction in children. This chapter presents developmental and long-lasting memory disorders emerging from an organic or neurologic cause at birth or in infancy. More notably, we focus on developmental amnesic syndrome caused by neonatal bihippocampal damage and memory dysfunction caused by medial temporal developmental epilepsy. We describe these two pediatric populations and present the consequences of hippocampal/medial temporal lobe damage in the development of memory systems. We review episodic memory deficits in children with developmental amnesia and temporal lobe epilepsy and highlight their impact on new learning, personal memories, and independent life. Finally, we provide a brief overview of some of the insights and debates emerging from classic work and recent advances in the context of episodic memory dysfunction displayed by children with hippocampal/medial temporal lobe amnesia and propose new perspectives in child neuropsychology of memory, suggesting new avenues for more ecologic memory assessment and rehabilitation.


Subject(s)
Memory Disorders , Memory, Episodic , Amnesia/etiology , Hippocampus , Humans , Memory Disorders/etiology , Neuropsychological Tests , Temporal Lobe
4.
Epilepsy Behav ; 99: 106482, 2019 10.
Article in English | MEDLINE | ID: mdl-31461681

ABSTRACT

PURPOSE: Executive functions (EF) are high-order cognitive skills that have a major influence on quality of life, social skills, and school achievement. We aimed to screen EF daily life abilities in young patients with myoclonic-atonic epilepsy (MAE) using an ecological questionnaire and to correlate EF to epilepsy characteristics. METHODS: Behavioral Rating Inventory of Executive Functions - Preschool (BRIEF-P) and BRIEF - for school-aged patients - parental questionnaires were proposed to patients with MAE and typically developing children (TDC) including Inhibit, Shift, Emotional control, Working memory (WM), Plan/Organize, Initiate, Organization of materials, and Monitor subscales. We included prospectively 12 patients with MAE and 44 TDC aged 3 to 5 years and seven patients with MAE and 21 TDC aged 6-7 years. We performed in addition for all patients an intellectual efficiency evaluation using WPPSI-IV (Wechsler intelligence scale for preschool children version IV) and collected demographics, age at onset of epilepsy, epilepsy duration, response to treatment, number and type of treatments including AEDs (antiepileptic drugs), and ketogenic diet. RESULTS: Four out of 12 patients for BRIEF-P and 6/7 patients for BRIEF had pathological scores for at least one domain. Behavioral Rating Inventory of Executive Functions' questionnaires showed higher pathological scores for WM, Plan/Organize, Initiate, Monitor, and Metacognition Index in patients with MAE compared to TDC suggesting higher problems reported by parents. Working memory scores were higher in the group with MAE than TDC for both BRIEF-P and BRIEF. Response to treatment is a predictor of multiple BRIEF-P domains. Epilepsy duration predicts Shift and WM domains while age at onset predicts WM domain on BRIEF in this syndrome. CONCLUSIONS: This study is the first to assess prospectively EF in young patients with MAE. We show everyday deficits in EF reported by parents. Metacognition and more specifically WM, appear to be a core deficit. Early evaluation of EF using both questionnaires and standardized tools is necessary for early detection of EF deficit and initiating tailored rehabilitation. Given the normal development before seizure onset and the absence of cerebral lesion in MAE, these results are in favor of the impact of epilepsy on EF.


Subject(s)
Behavior Rating Scale/standards , Epilepsies, Myoclonic/physiopathology , Executive Function/physiology , Child , Child, Preschool , Female , Humans , Male
5.
Epilepsy Behav ; 69: 86-94, 2017 04.
Article in English | MEDLINE | ID: mdl-28236728

ABSTRACT

The neural networks involved in language recovery following hemispherotomy of the dominant hemisphere after language acquisition in children remain poorly known. Twelve hemispherotomized children (mean age at surgery: 11.3years) with comparable post-operative neuropsychological patterns underwent multi-task language functional MRI. Three of them had recovered from an initial postoperative aphasia i.e., hemispherotomy was performed on the language-dominant hemisphere. Our main results revealed (1) perisylvian activations in all patients after either left or right hemispherotomy; (2) no differences in activations between groups regarding the side of hemispherotomy; (3) additional activations in pre-frontal (3/3) and hippocampal/parahippocampal and occipito-parietal (2/3) areas, when comparing language activation in each of the three subjects with hemispherotomy of the language-dominant hemisphere to the group of 9 non-dominant hemispherotomized patients. These neural networks support the stronger engagement of learning and memory during language recovery in a hemisphere that was not initially actively subserving language.


Subject(s)
Brain/physiology , Functional Laterality/physiology , Hemispherectomy/trends , Language , Nerve Net/physiology , Neuronal Plasticity/physiology , Adolescent , Brain/diagnostic imaging , Brain/surgery , Brain Mapping/methods , Child , Female , Follow-Up Studies , Humans , Language Disorders/diagnostic imaging , Language Disorders/physiopathology , Language Tests , Magnetic Resonance Imaging/methods , Male , Nerve Net/diagnostic imaging , Nerve Net/surgery , Recovery of Function/physiology , Young Adult
6.
Epilepsy Behav ; 55: 139-45, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26773685

ABSTRACT

PURPOSE: Hemispherotomy (H) is the standard treatment used to cure hemispheric epileptic syndromes in childhood. The postoperative linguistic profile involves hemispheric specialization processes and developmental cognitive plasticity. This research concerns pragmatic aspects of language as a tool for communication which involves both linguistic and extralinguistic communication in context. Our aim was to analyze whether any correlation exists with age at surgery and side of surgery on pragmatic skills following H. METHOD: Forty children who underwent H (23 females, 16 right H) were evaluated at a mean age of 12.8 years (±2.6) with two receptive tasks (oral comprehension and syntactic judgment), the Children's Communication Checklist (CCC) rating scale, and the Behavioral Rating Inventory of Executive Function (BRIEF) questionnaire in order to evaluate the role of executive functions on pragmatic skills. Children operated on before the age of 18 months were considered the "early" group (5 right H and 9 left H), while those operated on later were called the "late" group (11 right H and 15 left H). KEY FINDINGS: The whole group had significant deficits in all three measures. We demonstrated a statistically significant crossed interaction between the side of H and the age at H with pragmatic language impairments (F(1,36)=17.48; p=.0002) and disorders in executive function (F(1,36)=5.80; p=.021) in left early H and in right late H patients. These findings are consistent with the previous studies of pragmatic language impairments concerning adolescents and adults with right hemisphere damage and emphasize the contribution of structural language in the early stage of verbal communication. SIGNIFICANCE: These results emphasize for the first time that hemispherotomized children have pragmatic language impairments that are independent of receptive language. Our findings are congruent with the recent theory on pragmatic language development in childhood with evidence of a participation of the left hemisphere at the early age followed by right hemispheric specialization and involvement of executive functions, independently of receptive language.


Subject(s)
Dominance, Cerebral/physiology , Epilepsy/surgery , Language Disorders/etiology , Language , Neurosurgical Procedures/adverse effects , Speech/physiology , Adolescent , Child , Communication , Comprehension/physiology , Female , Humans , Language Tests , Male
7.
Epilepsy Behav ; 53: 51-7, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26519666

ABSTRACT

PURPOSE: Hemispherotomy (H) is the gold standard treatment to cure epilepsy in Rasmussen encephalitis (RE). Linguistic prognosis after surgery remains the main issue when the dominant hemisphere is involved. The topic of the present research is to specify the long-term linguistic profile of the right hemisphere after left dominant H for RE. METHODS: We followed 6 children 8.4 to 14.6 years of age who underwent left H for RE. Preoperatively, four children experienced aphasia, but for two, worsening occurred after surgery. Age at H ranged from 4.1 to 8.4 years. The mean duration of epilepsy was 1.2 years and 5.6 years for follow-up. Neuropsychological evaluation included longitudinal follow-up of intellectual efficiency measurement and a long-term outcome of language using various components of receptive and expressive oral speech with computerized tasks. KEY FINDINGS: Preoperatively, verbal comprehension index (VCI) was dramatically decreased in 4/6 patients, and performance reasoning index (PRI) was low in 5/6 participants, demonstrating a global impact of RE itself. Postoperatively, all children recovered sufficiently to attend a regular VCI (above 70) in a mean of 5 years after H, and 5/6 recovered normal or adapted school. There was a dissociation in favor of VCI, while PRI decreased in 5/6 patients. We found a specific linguistic profile for these children recovering language in the right hemisphere: normal verbal comprehension, and weakness of grammatical judgment, word repetition, statement production, semantic verbal fluency and metaphonological abilities. Language recovery scores were statistically correlated with those of Working Memory Index. SIGNIFICANCE: This study emphasizes for the first time the ability of the right hemisphere to functionally reorganize language over a long period of time following left H for RE. Syntactic abilities and phonology remain low and support the hypothesis of an early left hemispheric specialization. Nevertheless, lexico-semantic processes recover in the right hemisphere that could reflect a pre-existing potential of both hemispheres. Our results support a decision to proceed to H in classical left RE disease until the late childhood even if there is no complete aphasia before surgery. These data should be taken in account in the overall postoperative follow-up and rehabilitation strategy.


Subject(s)
Dominance, Cerebral , Encephalitis/physiopathology , Encephalitis/surgery , Hemispherectomy , Language , Adolescent , Aphasia , Child , Comprehension , Dominance, Cerebral/physiology , Encephalitis/psychology , Epilepsy/surgery , Female , Follow-Up Studies , Humans , Language Tests , Linguistics , Male , Memory, Short-Term , Neuropsychological Tests , Postoperative Period , Semantics , Speech , Verbal Behavior
8.
Epilepsy Behav ; 44: 86-9, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25659044

ABSTRACT

While the current literature on children suffering from temporal lobe epilepsy (CTLE) mostly focuses on material-related episodic memory deficits according to seizure-onset lateralization, the present study examined associative episodic memory according to the type of information to memorize (e.g., factual, spatial, and sequential) and further investigated subjective and objective recollection. Eleven children with left temporal lobe epilepsy (LTLE), 10 children with right temporal lobe epilepsy (RTLE), among whom 9 displayed hippocampal sclerosis (HS), and 42 healthy controls completed the WHAT-WHEN-WHERE protocol (Guillery-Girard et al., 2013). Group comparisons were first conducted according to the affected side and second according to the underlying pathology. Results showed associative memory impairments in patients irrespective of the affected side. Moreover, this study revealed that HS is particularly deleterious to associative and subjective recollection in CTLE. In addition, this study emphasizes the need for assessing episodic memory in childhood TLE beyond material specificity.


Subject(s)
Association Learning/physiology , Epilepsy, Temporal Lobe/physiopathology , Hippocampus/pathology , Memory Disorders/physiopathology , Memory, Episodic , Mental Recall/physiology , Adolescent , Child , Epilepsy, Temporal Lobe/complications , Female , Functional Laterality , Humans , Male , Memory Disorders/etiology , Sclerosis/pathology , Temporal Lobe/pathology
9.
Child Neuropsychol ; 21(4): 451-64, 2015.
Article in English | MEDLINE | ID: mdl-24814800

ABSTRACT

This study addresses the relation between lexico-semantic body knowledge (i.e., body semantics) and spatial body representation (i.e., structural body representation) by analyzing naming performances as a function of body structural topography. One hundred and forty-one children ranging from 5 years 2 months to 10 years 5 months old were asked to provide a lexical label for isolated body part pictures. We compared the children's naming performances according to the location of the body parts (body parts vs. head features and also upper vs. lower limbs) or to their involvement in motor skills (distal segments, joints, and broader body parts). The results showed that the children's naming performance was better for facial body parts than for other body parts. Furthermore, it was found that the naming of body parts was better for body parts related to action. These findings suggest that the development of a spatial body representation shapes the elaboration of semantic body representation processing. Moreover, this influence was not limited to younger children. In our discussion of these results, we focus on the important role of action in the development of body representations and semantic organization.


Subject(s)
Body Image , Knowledge , Semantics , Child , Child, Preschool , Female , Humans , Male , Motor Skills , Reaction Time/physiology
10.
Neurocase ; 21(2): 144-7, 2015.
Article in English | MEDLINE | ID: mdl-24471481

ABSTRACT

We report a longitudinal case study of a left-handed girl who underwent left hemispherotomy at 7 years for Rasmussen encephalitis (RE). Presurgical evaluation showed mild hemiparesis, no visual defect, and light neuropsychological impairment with short-term memory weakness. Language fMRI showed a right hemispheric dominance. Postoperatively, the patient exhibited right hemiplegia and hemianopsia but preserved intellectual capacities. She became seizure-free, and antiepileptic medication was discontinued. Long-term follow-up showed very high verbal intelligence at 11 years of age (VCI of 155) and improvement in working memory as well as language and reading abilities. Furthermore, a significant visuoverbal discrepancy became increasingly pronounced. Thus, early surgical treatment of epilepsy avoided the global cognitive deterioration usually associated with RE. Finally, such a high level of verbal functioning combined with low spatial reasoning with a single hemisphere provides additional information on the neurocognitive profile of children with RE after hemispherotomy.


Subject(s)
Brain/physiopathology , Encephalitis/physiopathology , Encephalitis/psychology , Intelligence/physiology , Brain Mapping , Child , Encephalitis/surgery , Female , Functional Laterality/physiology , Hemispherectomy , Humans , Intelligence Tests , Magnetic Resonance Imaging , Neuropsychological Tests , Reading
11.
Dev Neuropsychol ; 39(5): 365-84, 2014.
Article in English | MEDLINE | ID: mdl-25090015

ABSTRACT

This longitudinal study investigates executive functions (EF) in children with transposition of the great arteries (TGA) compared to typically developing children at a key age period between 5 and 7 years. We explored the presence and evolution of specific impairments on three core EF components (inhibition, working memory, and cognitive flexibility). Ninety children were evaluated for three consecutive years. Results demonstrated significant delays in inhibition and cognitive flexibility despite normal working memory. Impairments did not systematically worsen with age. EF impairments after TGA are dynamic and may affect selective components. Cyanotic congenital heart disease is associated with altered EF development.


Subject(s)
Executive Function , Transposition of Great Vessels/psychology , Aging/physiology , Aging/psychology , Case-Control Studies , Child , Child, Preschool , Cognition , Female , Humans , Inhibition, Psychological , Longitudinal Studies , Male , Memory, Short-Term , Transposition of Great Vessels/physiopathology
12.
Dev Med Child Neurol ; 56(6): 564-71, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24444170

ABSTRACT

AIM: Theory of mind impairments are part of the cognitive morbidities associated with transposition of the great arteries (TGA). We sought to assess core components of social cognition in school-aged children with TGA. METHOD: Thirty-eight children with neonatal corrected TGA (27 males, 11 females; mean age 7y 3mo, SD 1y 2mo) and a comparison group (n=31; 24 males, 7 females; mean age 7y 4mo, SD 1y 1mo) participated in this study. All children completed measures of facial expression recognition, emotion comprehension, and second-order cognitive and affective false-belief tasks. The association of medical pre-, intra-, and postoperative variables with cognitive outcomes was explored. RESULTS: After controlling for potential covariates, children with TGA performed significantly less accurately in the mental category of the emotion comprehension battery (p=0.002) and on second-order affective false-belief tasks (p<0.05). Preoperative variables including an associated ventricular septal defect (p=0.02), a younger age at open-heart surgery (p=0.03), and a prenatal diagnosis of TGA (p=0.02) were significantly associated with better outcomes. INTERPRETATION: School-aged children with TGA display significant impairment on complex affective mental state understanding even though facial expression recognition was generally preserved. Preoperative factors may be important determinants for long-term outcomes after cyanotic congenital heart disease.


Subject(s)
Cognition Disorders/psychology , Emotional Intelligence , Facial Expression , Postoperative Complications/psychology , Recognition, Psychology , Theory of Mind , Transposition of Great Vessels/surgery , Child , Child, Preschool , Cognition Disorders/diagnosis , Comorbidity , Comprehension , Female , Follow-Up Studies , Heart Septal Defects, Ventricular/psychology , Heart Septal Defects, Ventricular/surgery , Humans , Infant , Infant, Newborn , Male , Neuropsychological Tests/statistics & numerical data , Postoperative Complications/diagnosis , Prognosis , Psychometrics , Transposition of Great Vessels/psychology
13.
Neurocase ; 20(1): 87-99, 2014.
Article in English | MEDLINE | ID: mdl-23116198

ABSTRACT

We present a 16 year-old right-handed case who underwent a left temporo-occipital resection to treat intractable epilepsy. Pre- and post-surgical evaluations showed an average intellectual quotient, preserved abilities in language and visuo-spatial functions and increased reading and spelling deficits (difficulties with irregular words, homophones and phonologically valid spelling errors of irregularly spelled words, associated with preserved performances in non-words). This pattern of characteristic lexical route deficits highlights the major role of the temporo-occipital areas in reading acquisition. We discussed the consequences of temporo-occipital dysfunction on reading.


Subject(s)
Dyslexia, Acquired/surgery , Epilepsies, Partial/surgery , Epilepsy, Temporal Lobe/surgery , Adolescent , Dyslexia, Acquired/diagnosis , Dyslexia, Acquired/physiopathology , Epilepsies, Partial/pathology , Epilepsies, Partial/physiopathology , Epilepsy, Temporal Lobe/pathology , Epilepsy, Temporal Lobe/physiopathology , Female , Humans , Male
14.
Orphanet J Rare Dis ; 8: 176, 2013 Nov 13.
Article in English | MEDLINE | ID: mdl-24225340

ABSTRACT

BACKGROUND: Dravet syndrome (DS) is currently considered as an epileptic encephalopathy, a condition in which epilepsy causes deterioration or developmental delay but preliminary data suggested that cognitive course may worsen independently from epilepsy. Our objective was to prospectively analyze the neuropsychological features in a large cohort of DS patients and its relationships with epilepsy and SCN1A mutation. METHODS: 81 examinations were performed in 67 patients with typical DS (9m-24y, 15 longitudinally studied) using Brunet-Lezine (developmental/intelligence quotient [DQ/IQ] and DQ sub-scores), Achenbach, Conners, and a semi-quantitative psychomotor score (SQPS). We studied the correlation between DQ/IQ/SQPS and age, epilepsy characteristics, and whether patients presented SCN1A mutation. RESULTS: DQ/IQ significantly decreased with age (r = -.53, p < .001), from normal before 2y (mean 80, range 64-105) to low after 3y (mean 48, range 30-69), with hyperactivity and attention disorders hampering learning abilities especially up to 6y. However, raw (not age-adjusted) DQ sub-scores increased with age during the first decade, showing that there is no regression. We did not find any significant correlation between DQ/IQ at last evaluation and epilepsy data, i.e. first seizure (age, type, duration, fever), seizures during the course (type, fever sensitivity), status epilepticus (age of onset, number, fever), photosensitivity, and treatment, except for myoclonus and focal seizures which were associated with a lower QD/IQ after 3y. SCN1A mutated patients (n = 58) seemed to exhibit worse psychomotor course than non-mutated ones (n = 9) (severe SQPS in 26% vs 0%), although their epilepsy tended to be less severe (tonic seizures in 12% vs 44% [p = 0.04], first status epilepticus before 6 m in 26% vs 67% [p = .02], mean number of SE 2.5 vs 4.5 [p = .09]). DQ sub-scores were dissociated throughout the whole course: from onset hand-eye coordination was significantly lower than language, posture and sociability (p < .01). Dissociation seemed to be more frequent in mutated than in non-mutated patients (motor SQPS was normal for in 77% vs 44% [p = 0.017] whereas language SQPS was normal for 47% vs 100%). CONCLUSIONS: Although psychomotor/cognitive delay declines with age, there is no regression. In addition, encephalopathy is not a pure consequence of epilepsy but SCN1A mutation seems to play an additional, direct role.


Subject(s)
Epilepsies, Myoclonic/physiopathology , Epilepsy/physiopathology , Intellectual Disability/etiology , Spasms, Infantile/etiology , Adolescent , Adult , Child , Child, Preschool , Epilepsies, Myoclonic/genetics , Epilepsy/etiology , Female , Humans , Infant , Intellectual Disability/genetics , Lennox Gastaut Syndrome , Longitudinal Studies , Male , Mutation , NAV1.1 Voltage-Gated Sodium Channel/genetics , Spasms, Infantile/genetics , Young Adult
15.
Front Behav Neurosci ; 7: 126, 2013.
Article in English | MEDLINE | ID: mdl-24098276

ABSTRACT

Episodic memory refers to the capacity to bind multimodal memories to constitute a unique personal event. Most developmental studies on episodic memory focused on one specific component, i.e., the core factual information. The present study examines the relevance of a novel episodic paradigm to assess its developmental trajectories in a more comprehensive way according to the type of association (item-feature, item-location, and item-sequence associations) with measures of both objective and subjective recollection. We conducted a behavioral study aimed at testing the effects of age in a large sample of 160 children, adolescents, and young adults (6-23 years old). We confronted the behavioral data to the neural correlates in a subgroup of 30 children using voxel-based morphometry. Behavioral data outlined differential developmental trajectories according to the type of association, with a continuous increase of factual associative memory efficiency until 10 years, a linear increase of performance in spatial associative memory that pursues until early adulthood and an abrupt increase in temporal associative memory efficiency between 9 and 10. Regarding recollection, measures showed a more pronounced enhancement from 9 to 10 years. Hence, behavioral data highlight a peculiar period in late childhood (8-10 years old) crucial for the developmental time course of episodic memory. Regarding structural data, we found that the improvement of associative memory efficiency was related to a decrease in gray matter volume in a large cerebral network including the dorsolateral and ventrolateral prefrontal cortex (and superior and anterior temporal regions), and the hippocampus bilaterally. These data suggest that multimodal integration would probably be related to the maturation of temporal regions and modulated by a fronto-parietal network. Besides, our findings emphasize the relevance of the present paradigm to assess episodic memory especially in the clinical setting.

16.
J Pediatr ; 163(4): 1105-10.e1, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23768817

ABSTRACT

OBJECTIVES: To characterize the prevalence of use of early remedial services and its associated demographic, medical, and cognitive factors in children aged 4-6 years with corrected transposition of the great arteries (TGA). STUDY DESIGN: This was a prospective study of neurocognitive outcomes after TGA. Children underwent formal neuropsychological testing including general intelligence and a comprehensive battery of executive functions (EF) including motor and interference control, short-term memory, and working memory as well as cognitive flexibility. Parental reports on the children's behavior and EF were also evaluated. Demographic factors and preoperative, intraoperative, and postoperative factors as well as cognitive factors were examined according to the current use of remediation. RESULTS: Forty-five patients (67% male) and their parents participated in this study. Twenty-four (53%) patients were receiving remedial services. Male sex, a postnatal diagnosis of TGA, and a longer postoperative intensive care unit stay were significantly associated with use of remediation. Children receiving remediation had lower EF scores, had more severe EF deficits as observed by formal testing, and were rated as having more behavioral daily life difficulties. However, in the group without remediation, 13 children (43%) also displayed EF deficits rated as moderate to severe. CONCLUSIONS: Demographic and medical factors could help identify children at higher risk for neurocognitive delays. Evaluation of executive functioning from an early age may influence referral for remediation.


Subject(s)
Developmental Disabilities/therapy , Early Intervention, Educational , Transposition of Great Vessels/physiopathology , Transposition of Great Vessels/surgery , Child , Child, Preschool , Developmental Disabilities/diagnosis , Emotions , Female , Humans , Intelligence Tests , Male , Neuropsychological Tests , Parents , Prospective Studies , Risk
17.
Handb Clin Neurol ; 111: 797-802, 2013.
Article in English | MEDLINE | ID: mdl-23622227

ABSTRACT

Epilepsy surgery is now widely accepted as an effective therapeutic option for carefully selected children with medically refractory epilepsy. The surgical procedure may cause cognitive deficits or exacerbate existing impairments, but it may also improve cognitive abilities by the restoration of functions located in adjacent or contralateral areas that had been secondarily affected by the epilepsy or the underlying pathology. Compared to adults, better cognitive outcome has been reported in children, a finding probably due to the developing state of the brain, which possesses considerable structural and functional plasticity. More extensive and effective surgery such as hemispherectomy is more commonly used in the pediatric population, and this must also influence surgical outcome. However, studies related to cognitive outcome of epilepsy surgery in children are limited, and controversial results are often reported. In this chapter, we provide a current overview of the literature on cognitive outcomes in children who undergo different types of epilepsy surgery, including focal resections as well as corpus callosotomy and hemispherectomy. Early surgical intervention appears to be a rational option for the treatment of childhood epilepsy since many cognitive deficits are linked to the epileptic process and may disappear when seizures are controlled.


Subject(s)
Cognition Disorders/etiology , Neurosurgical Procedures/adverse effects , Postoperative Complications/physiopathology , Epilepsy/surgery , Humans
18.
Cortex ; 49(5): 1386-93, 2013 May.
Article in English | MEDLINE | ID: mdl-22901711

ABSTRACT

INTRODUCTION: Recognition memory may be enhanced for emotional stimuli compared to neutral ones. Neuropsychological studies in adults with temporal lobe epilepsy (TLE) have reported disorders in this emotional memory enhancement but few studies have focused on children and adolescents with TLE. However these young patients are at particular risk for memory impairments. METHODS: We included 25 patients aged 8-18 years with temporal lobe resection (TLR) for refractory TLE and compared them with 50 age-matched healthy controls for emotional memory recognition tasks involving faces and words. Recollection and familiarity memory processes were explored using the R/K/G paradigm and identification of emotional facial expressions was evaluated. RESULTS: In the control group, recognition was enhanced for emotional faces and words compared to neutral ones. In patients, no memory enhancement effect was found, except for fearful faces. Memory enhancement for fearful faces relied on familiarity-based judgments in patients whereas it was supported by recollection in controls. In left-TLR patients, memory recognition of emotional material was correlated with identification of emotional facial expressions whereas this was not the case for right-TLR patients. CONCLUSION: Together, these findings indicate that temporal lobe integrity is crucial for children to develop normal interactions between emotions and memory. In the case of early lesions, fearful expressions might possibly increase memory for faces but through familiarity rather than through recollection as in healthy individuals.


Subject(s)
Emotions/physiology , Epilepsy, Temporal Lobe/physiopathology , Face/physiopathology , Memory/physiology , Temporal Lobe/physiopathology , Adolescent , Child , Epilepsy, Temporal Lobe/pathology , Epilepsy, Temporal Lobe/surgery , Facial Expression , Humans , Judgment/physiology , Neuropsychological Tests , Recognition, Psychology , Temporal Lobe/pathology , Temporal Lobe/surgery
19.
Front Hum Neurosci ; 7: 901, 2013.
Article in English | MEDLINE | ID: mdl-24399958

ABSTRACT

Enhanced memory for emotional faces is a significant component of adaptive social interactions, but little is known on its neural developmental correlates. We explored the role of amygdaloid complex (AC) and medial temporal lobe (MTL) in emotional memory recognition across development, by comparing fMRI activations of successful memory encoding of fearful and neutral faces in children (n = 12; 8-12 years) and adolescents (n = 12; 13-17 years). Memory for fearful faces was enhanced compared with neutral ones in adolescents, as opposed to children. In adolescents, activations associated with successful encoding of fearful faces were centered on baso-lateral AC nuclei, hippocampus, enthorhinal and parahippocampal cortices. In children, successful encoding of fearful faces relied on activations of centro-mesial AC nuclei, which was not accompanied by functional activation of MTL memory structures. Successful encoding of neutral faces depended on activations in anterior MTL region (hippocampal head and body) in adolescents, but more posterior ones (hippocampal tail and parahippocampal cortex) in children. In conclusion, two distinct functional specializations emerge from childhood to adolescence and result in the enhancement of memory for these particular stimuli: the specialization of baso-lateral AC nuclei, which is associated with the expertise in processing emotional facial expression, and which is intimately related to the specialization of MTL memory network. How the interplay between specialization of AC nuclei and of MTL memory structures is fundamental for the edification of social interactions remains to be elucidated.

20.
J Pediatr ; 161(1): 94-8.e1, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22284567

ABSTRACT

OBJECTIVES: To assess the effect of prenatal diagnosis of congenital heart disease on neurocognitive outcomes in children with d-transposition of the great arteries (TGA) after surgical correction. STUDY DESIGN: A prospective study of children born with a TGA between 2003 and 2005 and aged 4 to 6 years was conducted. General intelligence, language, executive functions, and social cognition scores and preoperative, intraoperative, and postoperative factors were evaluated according to time of TGA diagnosis. Neurocognitive data were also compared with a control group. RESULTS: Forty-five eligible patients (67% male) were examined; 29 had a prenatal diagnosis of TGA and 16 did not. All children were comparable in age, sex, and demographic variables. Diagnostic groups did not differ in preoperative, intraoperative, and postoperative variables. Preoperative acidosis was more frequent in the postnatal group (18% versus 3%). All patients had normal IQ scores, language, and verbal working memory. However, neurocognitive deficits were more prevalent and more severe in children with a postnatal-TGA. Prenatal diagnosis was associated with better outcomes in executive functions. CONCLUSIONS: Prenatal diagnosis of TGA is associated with better neurocognitive outcomes. Time of diagnosis may influence the development of early complex cognitive skills such as executive functions.


Subject(s)
Cognition , Nervous System/growth & development , Prenatal Diagnosis , Transposition of Great Vessels/diagnosis , Child , Child, Preschool , Female , Humans , Male , Prospective Studies , Transposition of Great Vessels/surgery , Treatment Outcome
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