ABSTRACT
OBJECTIVE: To determine whether the inferior vena cava (IVC) measurement by bedside ultrasound (US-IVC) predicts improvement in renal function in patients with acute kidney injury (AKI). DESIGN: Prospective observational study. SETTING: Medical intensive care unit. PATIENTS: 33 patients with AKI were included. INTERVENTION: US-IVC was done on admission. The patients' management was done by the primary teams, who were unaware of the US-IVC findings. Two groups of patients were identified. Group 1 included patients who were managed in concordance with their US-IVC (potential volume responders who had a positive fluid balance at 48 h after admission and potential volume nonresponders who had an even or negative fluid balance at 48 hours after admission). Group 2 included patients in whom the fluid management was discordant with their US-IVC. MEASUREMENTS AND MAIN RESULTS: At 48 hours, Group 1 patients had a greater improvement in creatinine [85% versus 31%, p = 0.0002], creatinine clearance (78 ± 93% versus 8 ± 64%, p = 0.002), and urine output (0.86 ± 0.54 versus 0.45 ± 0.36 ml/Kg/h, p = 0.03). CONCLUSION: In critically ill patients with AKI, concurrence of fluid therapy with IVC predicted fluid management, as assessed by bedside ultrasound, was associated with improved renal function at 48 hours. This trial is registered with ClinicalTrials.gov registration number: NCT02064244.
Subject(s)
Arteriovenous Malformations , Hematuria , Iliac Aneurysm , Iliac Artery/abnormalities , Pulmonary Embolism , Urinary Bladder , Vascular Surgical Procedures/methods , Arteriovenous Malformations/diagnostic imaging , Arteriovenous Malformations/physiopathology , Arteriovenous Malformations/surgery , Decompression, Surgical/methods , Disease Management , Female , Hematuria/diagnosis , Hematuria/etiology , Hematuria/therapy , Humans , Iliac Aneurysm/diagnostic imaging , Iliac Aneurysm/physiopathology , Iliac Aneurysm/surgery , Middle Aged , Pulmonary Artery/diagnostic imaging , Pulmonary Artery/pathology , Pulmonary Embolism/diagnostic imaging , Pulmonary Embolism/physiopathology , Radiography , Risk Assessment , SyndromeSubject(s)
Lung Diseases/diagnosis , Lung , Ossification, Heterotopic/diagnosis , Biopsy , Humans , Lung/diagnostic imaging , Lung/pathology , Lung Diseases/diagnostic imaging , Lung Diseases/pathology , Male , Middle Aged , Ossification, Heterotopic/diagnostic imaging , Ossification, Heterotopic/pathology , Predictive Value of Tests , Prognosis , Tomography, X-Ray ComputedABSTRACT
A 61 year-old man presented with progressive shortness of breath. Computed tomography scan of the chest showed diffuse ground glass infiltrates and dilated pulmonary vessels in the right lung in addition to bilateral pulmonary masses with obstruction of the left main pulmonary bronchus. The patient underwent bronchoscopy with destruction of the tumor obstructing the left main pulmonary bronchus, resulting in clinical improvement and resolution of the right pulmonary infiltrates. We hypothesize that the patient developed right pulmonary edema secondary to hypoxic vasoconstriction of the left lung. This case suggests a rare mechanism of unilateral pulmonary edema and supports inclusion of pulmonary edema in the differential diagnosis of unilateral pulmonary infiltrates in the setting of contralateral bronchial obstruction.
Subject(s)
Bronchoscopy/methods , Lung , Pulmonary Edema , Airway Obstruction/complications , Airway Obstruction/diagnosis , Airway Obstruction/physiopathology , Airway Obstruction/surgery , Diagnosis, Differential , Disease Management , Humans , Lung/pathology , Lung/physiopathology , Male , Middle Aged , Pulmonary Edema/diagnosis , Pulmonary Edema/etiology , Pulmonary Edema/physiopathology , Pulmonary Edema/therapy , Tomography, X-Ray ComputedABSTRACT
Japanese yew is a widely used ornamental plant. However, most people are unaware that it is also a poisonous plant. It has potent cardiac toxicities that can lead to sudden cardiac death. A 37-year-old female patient presented to the emergency room with altered mental status and sustained ventricular tachycardia (VT). Electrocardiogram (ECG) after cardioversion showed profound QRS prolongation and ST-segment elevation suggestive of either hyperkalaemia, acute myocardial ischaemia, or Brugada syndrome. Her electrolytes and coronary angiography were normal. After improvement of the patient's mental status, she admitted that she has been consuming Japanese yew from her yard for several months. Few hours later, QRS duration normalised, but mild ST-segment elevation persisted in the right pre-cordial leads, making it more suspicious for Brugada syndrome. However, a procainamide challenge test and electrophysiology study failed to induce typical Brugada pattern ECG and VT. The absence of coronary artery disease and electrolytes disturbances points toward the fact that her arrhythmia and ECG changes are secondary to yew intoxication. The patient was monitored for a few days. She was haemodynamically stable and has not had any arrhythmia. This case highlights the importance of public awareness of severe toxicity from Japanese yew or other yew plants. Yews contain taxines that are responsible for the ECG abnormalities due to its inhibitory effect on the cardiac sodium and calcium channels. They cause conduction abnormalities, VT, and ST-segment elevation that can resemble acute myocardial infarction, hyperkalaemia, and Brugada syndrome.
