ABSTRACT
Eosinophilic granuloma EG is a benign self-limiting disease, which belongs to the spectrum of Langerhans' cell histiocytosis LCH. The etiology of LCH remains unknown, although the evidence indicates that it is a clonal proliferative disorder of Langerhans cells, it has also been characterized as reactive disorder, neoplastic process and a berrant immune response. Eosinophilic granuloma is characterized by single or multiple skeletal lesions occurring predominately in children, adolescents and young adults, it accounts for 70% of LCH. It is more common in males, and the common sites are the skull, mandible, ribs, spines and long bones particularly the femur and the humerus. The estimated incidence of EG is 3-4 per million of the population. Vertebral bone involvement is rarely seen and usually affects the vertebral body. We are reporting an unusual case of EG in a female child presented with a solitary lesion at posterior element of lumbar vertebra.
Subject(s)
Eosinophilic Granuloma/diagnosis , Lumbar Vertebrae/pathology , Spinal Diseases/diagnosis , Biopsy, Needle , Bone Transplantation/methods , Child , Combined Modality Therapy , Curettage/methods , Eosinophilic Granuloma/surgery , Female , Follow-Up Studies , Humans , Immunohistochemistry , Low Back Pain/diagnosis , Low Back Pain/etiology , Lumbar Vertebrae/surgery , Risk Assessment , Severity of Illness Index , Spinal Diseases/surgery , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
Eosinophilic granuloma EG is a well-recognized benign form of Langerhans cell histiocytosis, most commonly involving the skull bones. In this paper, we report an 8-year-old girl with EG of posterior element of vertebra; she had complete resolution with surgical curettage and bone grafting.
