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Facile and highly stereoselective synthesis of the tetracyclic erythrinane core.

Allin, Steven M; James, Stella L; Elsegood, Mark R J; Martin, William P.

J Org Chem ; 67(26): 9464-7, 2002 Dec 27.

Article in English | MEDLINE | ID: mdl-12492356

ABSTRACT

A highly stereoselective synthesis of the tetracyclic core of the Erythrina alkaloids is reported through the application of a Meyers bicyclic lactam template.

Subject(s)

Alkaloids/chemical synthesis , Combinatorial Chemistry Techniques , Erythrina/chemistry , Plants, Medicinal/chemistry , Cyclization , Models, Molecular , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Stereoisomerism , Structure-Activity Relationship

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