ABSTRACT
Prenatal diagnosis is essential in the new era of diagnosis and management of genetic diseases in obstetrics. Multiple ligation-dependent probe amplification (MLPA) is a recent technique for prenatal diagnosis for the relative quantification of 40 different nucleic acid sequences in one single reaction. We had utilized the MLPA technique in detecting aneuploidies in amniotic fluid samples from 25 pregnant women from the Obstetrics and Gynaecology Department UKMMC, versus the quantitative fluorescent polymerase chain reaction (QF-PCR) method. Conclusive results were obtained in 18 cases and all were concordant with that of the QF-PCR. All four cases of trisomies were correctly identified including one case with maternal cell contamination.
Subject(s)
Amniocentesis/methods , Aneuploidy , Genetic Testing/methods , Nucleic Acid Amplification Techniques/methods , Polymerase Chain Reaction/methods , Prenatal Diagnosis/methods , Adult , DNA Probes , Female , Humans , Pregnancy , Young AdultABSTRACT
This is a cross sectional study to determine the relationship of postnatal depression (PND) and socio-cultural practices post-delivery among women in Kota Bharu, Kelantan. Four hundred and twenty one pregnant women were screened for depression between 36 - 42 weeks of pregnancy, 1 week and 4 - 6 weeks postpartum using Edinburgh Postnatal Depression Scale (EPDS). The women also completed questionnaires on socio-demography, psychosocial support and traditional postnatal care. The prevalence of PND at 4-6 weeks postpartum was 20.7%. Depressive symptoms at the end of pregnancy (p<0.05) and one week postpartum (p<0.05), worry about the baby (p<0.05), use of traditional medication (p<0.05) and traditional massage (p<0.05) were significantly associated with PND.
Subject(s)
Attitude to Health/ethnology , Culture , Depression, Postpartum/ethnology , Medicine, Traditional , Mothers/psychology , Adult , Cross-Sectional Studies , Demography , Depression, Postpartum/epidemiology , Depression, Postpartum/therapy , Female , Health Knowledge, Attitudes, Practice , Humans , Malaysia/epidemiology , Pregnancy , Prevalence , Risk Assessment , Risk Factors , Socioeconomic Factors , Surveys and QuestionnairesABSTRACT
Hodgkin's disease (HD) in association with pregnancy is rarely reported. Thus, the data in the management of pregnancy complicated by HD is limited. We report here the management of advanced HD in pregnancy that was treated successfully with chemotherapy.
