[Immunocytogenesis and formation of antibodies in experimentally aged animals (author's transl)]. / Uber die Immunozytogenese und Synthese der Antikörper bei experimentell gealterten Ratten

The authors use white rats with experimentally induced Progeria-like syndrome of Selye. The immunologic response following inoculation with the extracellular microbe-parasite D, pneumoniae and the intracellular parasite Br. abortus 19 is studied serologically, cellularly and biochemically. The experimentally aged rats show diminished and retarded plasmocyte reaction and weaker and slower agglutinine synthesis as compared with the controls. The immunochemical analysis of the serums of the experimentally aged rats reveals changes in the serum fractions and an affected ratio of albumin/globulin. The data suggest a disturbed adaptation and a reversal to an older ontogenic form of the aged organism.

[Cellular immunity against bacteria (intracellular and extracellular parasites) in experimentally aged rats (author's transl)]. / Zelluläre Immunität gegunüber Bakterien (intra- und extrazelluläre Parasiten) bei experimentell gealterten Ratten

The authors study the activity of RES in rats with Progeria-like syndrome of Selye, at the occasion of a repeated infection with bacteria--intracellular parasites (Brucella abortus 19) and bacteria--extracellular parasites (Diplococcus pneumoniae). They establish that immunization improves the activity of RES of the experimentally aged rats; still, its phagocytic and digestive functions remain by far feebler than those of the rats unsubjected to experimental ageing. By the aged animals the RES insufficiency is more pronounced towards the intracellular bacterium Brucella abortus 19, than towards the extracellular Diplococcus pneumoniae.

[Resistance against intra- and extracellular bacteria in experimentally aged rats (author's transl)]. / Resistenz gegen intra- und extrazelluläre Bakterien bei experimentell gealterten Ratten

The authors study the cellular activity of RES against the microbes intracellular and extracellular parasites in rats with pronounced Progeria-like syndrome of Selye. RES of the experimentally aged animals copes, through with a certain delay, with the invading extracellular bacterium Diplococcus pneumoniae, but is utterly helpless against the intracellular microbe Br. abortus 19. These relations are completly inverted in the rats that have not been experimentally aged.

[Morphology of the cells in the peritoneal exsudate and phosphatase activity of the peritoneal macrophages experimentally aged rats treated with the intracellular bacterium Brucella abortus 19 (author's transl)]. / Morphologie der Zellen im peritonealen Exsudat und die Phosphatase-Aktivität der peritonealen Makrophagen von experimentell gealterten Ratten, behandelt mit Brucella abortus 19

The authors study the morphology of the cells in the peritoneal exsudate and the phosphatase activity of the peritoneal macrophages, obtained from rats with Selye's Progeria-like syndrome. Judging by their morphologic characteristics the macrophages of the experimentally aged rats, before and after contact with Brucella abortus 19 do not differ from those obtained from the unsubjected to experimental ageing rats. The acid phosphatase activity and the adenosinetriphosphatase activity of the macrophages prior to contact with Brucella abortus 19 are nearly identical for both groups of animals. Following contact the activity of the enzymes increases but this increase is slower by aged rats and reaches its maximum 1--2 days later.