Is There a Direct Link between Sexual Satisfaction and Restrictions during the Second Wave of the COVID-19 Pandemic?

Background: Research suggested that the COVID-19 pandemic-related restrictions decreased sexual function and satisfaction. The present study examines the direct relationship between sexual satisfaction and restrictions during the second wave of the COVID-19 pandemic. Methods: A cross-sectional study was performed in Poland between 3 September 2020 and 18 January 2021. A convenience sample of 1364 adults, aged 18-67 (M = 25.13, SD = 6.45), among whom 62.39% were women, and 23.17% were single, completed anonymous web-based survey. The Sexual Satisfaction Questionnaire (SSQ) and Stringency Index (IS) were used to assess sexual satisfaction and the level of restrictions during the pandemic, respectively. Results: No direct association was found between sexual satisfaction and the level of restrictions during the lockdown. Sexual satisfaction was significantly worse among single participants than those living in a couple. No gender differences were found in sexual satisfaction. Conclusions: Future studies should examine an indirect association between sexual satisfaction and restrictions during the pandemic via stress and anxiety. Single relationship status should be considered a risk factor for sexual satisfaction, so single individuals should be a target group for prevention programs during the pandemic.

Temperature-Stimulated Morphological Features of Advanced High-Strength Medium-Mn TRIP Steel.

Advanced High-Strength Steels (AHSSs) are one of the most rapidly developing group of Fe-based metallic materials. Their excellent combination of high strength, ductility and formability is due to their complex microstructure and strain-induced martensitic transformation of metastable retained austenite (RA), which favors extra ductility of the sheet steels. A deformation temperature is one of the most important factors affecting the phase transformation behavior in these Fe­C­Mn­Al­Si systems. Therefore, the present study aimed at understanding the temperature-dependent phase transformations and structural phenomena in an advanced medium-Mn­Al-alloyed steel. The 3Mn steel was thermomechanically processed and subjected to tensile testing in a temperature range from 20°C to 200°C. The different extent of the strain-induced martensitic transformation and some softening phenomena of bainitic ferrite matrix were revealed using transmission electron microscopy and electron backscatter diffraction techniques. It was found that the thermal stability of RA is strongly dependent on the deformation temperature. Moreover, the dynamic recovery and carbide precipitation play a key role when the deformation temperature is increased to 140°C and higher temperatures.

Metallurgical Characterization of Welded Joint of Nanostructured Bainite: Regeneration Technique versus Post Welding Heat Treatment.

One of the main limitations in application of nanostructured carbide-free bainite as a construction material is the difficulty of joining. This research presents a structural characterization of welded joints of medium carbon 55Si7 grade steel after the welding process with a regeneration technique as well as post welding heat treatment (PWHT). The hardness distribution of the welded joint with regeneration exhibit an overall decrease in hardness when compared to the base material and a significant decrease in hardness was observed in the heat-affected zone (HAZ). Unfavorable hardness distribution was caused by the presence of diffusion-type transformations products (pearlite) in the HAZ and bainite degradation processes. On the other hand, welding with the PWHT promotes the achievement of a comparable level of hardness and structure as in the base material. However, a slight decrease in hardness was observed in the weld zone due to the micro-segregation of the chemical composition caused by the indissoluble solidification structure. Based on the structural analysis, it was found that steel with relatively low hardenability (55Si7) should be welded using PWHT rather than a regeneration technique.

Microstructure Evolution and Mechanical Stability of Retained Austenite in Medium-Mn Steel Deformed at Different Temperatures.

The temperature-dependent microstructure evolution and corresponding mechanical stability of retained austenite in medium-Mn transformation induced plasticity (TRIP) 0.17C-3.1Mn-1.6Al type steel obtained by thermomechanical processing was investigated using scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), and X-ray diffraction (XRD) techniques. Specimens were deformed up to rupture in static tensile tests in the temperature range 20-200 °C. It was found that an increase in deformation temperature resulted in the reduced intensity of TRIP effect due to the higher stability of retained austenite. The kinetics of strain-induced martensitic transformation was affected by the carbon content of retained austenite (RA), its morphology, and localization in the microstructure.

N-Benzyladriamycin-14-valerate (AD 198): a non-cardiotoxic anthracycline that is cardioprotective through PKC-epsilon activation.

N-Benzyladriamycin-14-valerate (AD 198) is one of several novel anthracycline protein kinase C (PKC)-activating agents developed in our laboratories that demonstrates cytotoxic superiority over doxorubicin (Adriamycin; DOX) through its circumvention of multiple mechanisms of drug resistance. This characteristic is attributed at least partly to the principal cellular action of AD 198: PKC activation through binding to the C1b (diacylglycerol binding) regulatory domain. A significant dose-limiting effect of DOX is chronic, dose-dependent, and often irreversible cardiotoxicity ascribed to the generation of reactive oxygen species (ROS) from the semiquinone ring structure of DOX. Despite the incorporation of the same ring structure in AD 198, we hypothesized that AD 198 might also be cardioprotective through its ability to activate PKC-epsilon, a key component of protective ischemic preconditioning in cardiomyocytes. Chronic administration of fractional LD(50) doses of DOX and AD 198 to mice results in histological evidence of dose-dependent ventricular damage by DOX but is largely absent from AD 198-treated mice. The absence of significant cardiotoxicity with AD 198 occurs despite the equal ability of DOX and AD 198 to generate ROS in primary mouse cardiomyocytes. Excised rodent hearts perfused with AD 198 prior to hypoxia induced by vascular occlusion are protected from functional impairment to an extent comparable to preconditioning ischemia. AD 198-mediated cardioprotection correlates with increased PKC-epsilon activation and is inhibited in hearts from PKC-epsilon knockout mice. These results suggest that, despite ROS production, the net cardiac effect of AD 198 is protection through activation of PKC-epsilon.