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1.
Dermatologie (Heidelb) ; 74(9): 711-714, 2023 Sep.
Article in German | MEDLINE | ID: mdl-37341750

ABSTRACT

We report the case of a healthy young man who presented to our clinic with itchy skin lesions in the area of a tattoo on the back of the left hand. Bioptic and cultural confirmation of the pathogens led to the diagnosis of Mycobacterium chelonae infection. We initiated antibiotic therapy using azithromycin and linezolid with good response. Our case underlines that besides allergic skin reactions, infections as a complication after tattooing should also be included in the differential diagnosis.


Subject(s)
Mycobacterium Infections, Nontuberculous , Tattooing , Humans , Male , Adult , Mycobacterium Infections, Nontuberculous/diagnosis , Mycobacterium Infections, Nontuberculous/drug therapy , Tattooing/adverse effects , Skin Diseases, Bacterial/diagnosis , Anti-Bacterial Agents/therapeutic use , Mycobacterium chelonae , Azithromycin/therapeutic use , Linezolid/therapeutic use , Biopsy , Skin/pathology , Treatment Outcome
2.
Dermatologie (Heidelb) ; 73(7): 560-562, 2022 Jul.
Article in German | MEDLINE | ID: mdl-34633470

ABSTRACT

An 83-year-old woman presented to our outpatient clinic with bullous pemphigoid with a unilateral sparing of the left arm after axillary lymphadenectomy because of breast cancer. Cases of localized manifestations of bullous pemphigoid are mainly caused by lymphedema or radiation. The absence of blistering after lymphadenectomy is a rare and interesting manifestation. Pathophysiologically, blister formation may be attenuated or absent altogether due to decreased T­cell activation and thus reduced inflammatory infiltrate because of the absence of peripheral lymph nodes.


Subject(s)
Lymphedema , Pemphigoid, Bullous , Aged, 80 and over , Blister/pathology , Female , Humans , Lymph Node Excision/adverse effects , Lymph Nodes/surgery , Lymphedema/etiology , Pemphigoid, Bullous/etiology
3.
Hautarzt ; 66(10): 720-2, 2015 Oct.
Article in German | MEDLINE | ID: mdl-26311032

ABSTRACT

Cutaneous polyarteritis nodosa, a special form of polyarteritis nodosa (PAN) without systemic involvement, is classified as one of the ANCA-negative vasculitides of small and medium-sized vessels. It is a very rare disease with unknown etiology and occurs more commonly in women over the age of 40. Typical skin lesions are subcutaneous nodules, livedo racemosa, and ulcerations. We report the case of a 46-year-old woman presenting to our outpatient department who reported having very painful ulcerations of the lower legs with unknown origin for 6 months.


Subject(s)
Leg Ulcer/diagnosis , Leg Ulcer/etiology , Polyarteritis Nodosa/complications , Polyarteritis Nodosa/diagnosis , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Chronic Disease , Diagnosis, Differential , Female , Humans , Leg Ulcer/drug therapy , Middle Aged , Mycophenolic Acid/administration & dosage , Mycophenolic Acid/analogs & derivatives , Polyarteritis Nodosa/drug therapy , Treatment Outcome
4.
Hautarzt ; 66(4): 223-5, 2015 Apr.
Article in German | MEDLINE | ID: mdl-25732966

ABSTRACT

Condylomata acuminata (CA) are one of the most common sexually transmitted infections in the sexually active population. Due to the stigmatizing character of the disease and the high rate of relapse after therapy, CA may significantly affect patients' quality of life. Here, we report the case of successful treatment of multiple CA of the penis and scrotum in a 53-year-old man with ingenol mebutate gel.


Subject(s)
Condylomata Acuminata/drug therapy , Condylomata Acuminata/pathology , Diterpenes/administration & dosage , Penile Diseases/drug therapy , Penile Diseases/pathology , Humans , Male , Middle Aged , Treatment Outcome
5.
Am J Obstet Gynecol ; 165(5 Pt 1): 1552-7, 1991 Nov.
Article in English | MEDLINE | ID: mdl-1659787

ABSTRACT

The therapeutic effect of a single, oral dose of itraconazole was studied in rats inoculated intravaginally with Candida albicans and in which an established vaginal infection was present. We used light microscopy, transmission and scanning electron microscopy to document the structural alterations in the 3 days after treatment. The most important observations include the speed (within 24 hours) with which itraconazole inhibits the further penetration of the fungus into the vaginal squamous epithelium, the ability of the drug to reach and structurally alter intracellularly located fungal elements, and the prolonged drug effect of a single dose leading to complete eradication of the fungus from the vagina within 3 days.


Subject(s)
Antifungal Agents/therapeutic use , Candida albicans/drug effects , Candidiasis, Vulvovaginal/drug therapy , Ketoconazole/analogs & derivatives , Administration, Oral , Animals , Candida albicans/ultrastructure , Candidiasis, Vulvovaginal/pathology , Female , Itraconazole , Ketoconazole/therapeutic use , Microscopy, Electron , Rats , Rats, Inbred Strains
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