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1.
Alzheimers Res Ther ; 6(5-8): 53, 2014.
Article in English | MEDLINE | ID: mdl-25478024

ABSTRACT

INTRODUCTION: The aim of this review was to investigate whether there is a faster cognitive decline in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD) over time. METHODS: PsycINFO and Medline were searched from 1946 to February 2013. A quality rating from 1 to 15 (best) was applied to the included studies. A quantitative meta-analysis was done on studies with mini mental state examination (MMSE) as the outcome measure. RESULTS: A total of 18 studies were included. Of these, six (36%) reported significant differences in the rate of cognitive decline. Three studies reported a faster cognitive decline on MMSE in patients with mixed DLB and AD compared to pure forms, whereas two studies reported a faster decline on delayed recall and recognition in AD and one in DLB on verbal fluency. Mean quality scores for studies that did or did not differ were not significantly different. Six studies reported MMSE scores and were included in the meta-analysis, which showed no significant difference in annual decline on MMSE between DLB (mean 3.4) and AD (mean 3.3). CONCLUSIONS: Our findings do not support the hypothesis of a faster rate of cognitive decline in DLB compared to AD. Future studies should apply recent diagnostic criteria, as well as extensive diagnostic evaluation and ideally autopsy diagnosis. Studies with large enough samples, detailed cognitive tests, at least two years follow up and multivariate statistical analysis are also needed.

2.
J Parkinsons Dis ; 3(1): 69-76, 2013.
Article in English | MEDLINE | ID: mdl-23938313

ABSTRACT

BACKGROUND: Cognitive impairment is very common in patients with Parkinson's disease (PD). Brain changes accompanying cognitive decline in PD are still not fully established. METHODS: We applied cortical pattern matching and cortical thickness analyses to the three-dimensional T1-weighted brain MRI scans of 14 age-matched cognitively normal elderly (NC), 12 cognitively normal PD (PDC), and 11 PD dementia (PDD) subjects. We used linear regression models to investigate the effect of diagnosis on cortical thickness. All maps were adjusted for multiple comparisons using permutation testing with a threshold p < 0.01. RESULTS: PDD showed significantly thinner bilateral sensorimotor, perisylvian, lateral parietal, as well as right posterior cingulate, parieto-occipital, inferior temporal and lateral frontal cortices relative to NC (left p(corrected) = 0.06, right p(corrected) = 0.009). PDD showed significantly thinner bilateral sensorimotor, right frontal and right parietal-occipital cortices relative to PDC (right p(corrected) = 0.05). The absolute difference in cortical thickness between PDD and the other diagnostic groups ranged from 3% to 19%. CONCLUSION: Our data shows that cognitive decline in PD is associated with cortical atrophy. PDD subjects have the most widespread gray matter atrophy suggesting more cortical involvement as PD patients progress to dementia.


Subject(s)
Brain Mapping/methods , Brain/pathology , Dementia/pathology , Parkinson Disease/pathology , Aged , Analysis of Variance , Atrophy/pathology , Female , Humans , Magnetic Resonance Imaging , Male
3.
Mov Disord ; 26(8): 1541-4, 2011 Jul.
Article in English | MEDLINE | ID: mdl-21538519

ABSTRACT

BACKGROUND: We investigated to what extent cognitive impairment and dementia were related to the direct medical and nonmedical costs in Parkinson's disease. METHODS: Sixty-one patients with Parkinson's disease from a population-based cohort were assessed for motor and cognitive symptoms in 1993, 1997, and 2001. Data on use of health care and social services were collected. RESULTS: The costs of patients with dementia were 3.3 times higher (€34,980) than those of nondemented patients (€10,626) per year of survival. Institutional care was the largest cost factor, representing 67% of the costs. Cognitive functioning predicted direct costs by 29.4%. Cognitive decline was associated with increased costs, even in nondemented subjects. CONCLUSIONS: Our findings suggest that dementia has a substantial impact on direct costs in Parkinson's disease, mainly due to high costs for institutional care. In addition, there were indications that even patients with mild cognitive impairment have higher nonmedical costs.


Subject(s)
Cognition Disorders/economics , Cognition Disorders/etiology , Cost of Illness , Parkinson Disease/complications , Parkinson Disease/economics , Aged , Aged, 80 and over , Cognition Disorders/psychology , Cohort Studies , Female , Humans , Male , Middle Aged , Neuropsychological Tests , Parkinson Disease/psychology , Retrospective Studies
4.
Mov Disord ; 25(6): 687-95, 2010 Apr 30.
Article in English | MEDLINE | ID: mdl-20437538

ABSTRACT

Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini-Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend-level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between-group differences in radial distance ranged between 20-30% for caudate and 5-20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend-level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement.


Subject(s)
Caudate Nucleus/pathology , Cerebral Ventricles/pathology , Dementia/pathology , Hippocampus/pathology , Parkinson Disease/pathology , Aged , Aged, 80 and over , Analysis of Variance , Brain Mapping , Dementia/complications , Female , Humans , Image Processing, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Male , Parkinson Disease/complications
6.
J Neurol Neurosurg Psychiatry ; 78(3): 254-9, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17028119

ABSTRACT

BACKGROUND: Dementia is common in Parkinson's disease, but the underlying brain pathology is not yet fully understood. AIM: To examine the changes in the brain of patients with Parkinson's disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging. METHODS: Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson's disease and dementia (PDD; n = 16) and Parkinson's disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used. RESULTS: Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found. CONCLUSION: These findings show that dementia in Parkinson's disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.


Subject(s)
Brain/pathology , Cognition Disorders/pathology , Dementia/pathology , Parkinson Disease/complications , Aged , Case-Control Studies , Cognition Disorders/etiology , Dementia/etiology , Female , Humans , Magnetic Resonance Imaging , Male
7.
Mov Disord ; 21(9): 1343-9, 2006 Sep.
Article in English | MEDLINE | ID: mdl-16721732

ABSTRACT

The aim of this study was to establish the rate of progression from mild cognitive impairment (MCI) to dementia in patients with Parkinson's disease (PD). PD patients without dementia were recruited in 1997 from an ongoing prospective epidemiological study. The assessment included neurological and psychiatric examinations, a clinical interview based on the Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM-III-R) criteria for dementia, and a battery of neuropsychological tests. PD was diagnosed according to established criteria, dementia was diagnosed according to the DSM-III-R criteria, and subtypes of MCI were classified according to modified Petersen's criteria. Seventy-two nondemented PD patients were included. A total of 34 were cognitively intact, whereas 38 were diagnosed with MCI (amnestic, n = 6; single nonmemory domain, n = 17; multiple domains slightly impaired, n = 15). Fifty-nine patients (82%) completed follow-up examination 4 years later, and 18 (62%) of the patients with MCI and 6 (20%) of the cognitively intact PD patients were demented (P = 0.001). Single domain nonmemory MCI and multiple domains slightly impaired MCI were associated with later development of dementia (P = 0.003; P = 0.04), whereas amnestic MCI subtype was not (P = 0.76). We conclude that patients with PD and MCI had a higher risk of developing dementia than cognitively intact PD patients, suggesting that MCI in PD is an early manifestation of dementia. However, these findings should be interpreted with caution due to the relatively small number of subjects included in this study.


Subject(s)
Cognition Disorders/diagnosis , Dementia/diagnosis , Parkinson Disease/diagnosis , Aged , Aged, 80 and over , Amnesia/diagnosis , Diagnostic and Statistical Manual of Mental Disorders , Disability Evaluation , Disease Progression , Humans , Mental Status Schedule , Middle Aged , Neurologic Examination , Neuropsychological Tests , Norway
8.
Mov Disord ; 21(3): 337-42, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16211595

ABSTRACT

We describe the pattern of cognitive profiles within a community-based sample of patients with Parkinson's disease (PD) and dementia (PDD) using cluster analyses, and compare the results with data from patients with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Fifty patients with PDD and 39 with AD from Stavanger, Norway, and 62 patients with DLB from San Diego, CA, USA were diagnosed by either standardized clinical procedures or criteria (all PDD and all AD cases) or necropsy (all DLB cases). Four subgroups were identified: two subgroups with a subcortical cognitive profile (one with mild and one with moderate dementia severity), one subgroup with global impairment and severe dementia, and one subgroup with a cortical cognitive profile and moderate dementia. Of the patients with PDD and with DLB, 56% and 55%, respectively, had a subcortical cognitive profile, compared with only 33% of the AD patients. Conversely, 30% of the patients with PDD and 26% of those with DLB had a cortical cognitive profile, compared with 67% of the patients with AD. These findings suggest that in some patients with PDD, frontosubcortical changes are the main contributing factor to dementia, whereas in other patients, cortical and hippocampal changes are more important.


Subject(s)
Alzheimer Disease/epidemiology , Cognition Disorders/diagnosis , Cognition Disorders/epidemiology , Lewy Body Disease/epidemiology , Parkinson Disease/epidemiology , Aged , Alzheimer Disease/pathology , Brain/pathology , Cohort Studies , Female , Humans , Lewy Body Disease/pathology , Male , Neuropsychological Tests , Parkinson Disease/pathology , Severity of Illness Index
9.
J Geriatr Psychiatry Neurol ; 18(3): 149-54, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16100104

ABSTRACT

Although mild cognitive impairment and dementia are common and have important clinical consequences for patients with Parkinson's disease (PD) and their caregivers, it is still unclear whether cognitive symptoms may predict the development of dementia in PD patients. The objective of this study was to determine whether cognitive deficits in nondemented PD patients predicted the development of dementia 4 years later. A total of 76 nondemented PD patients from an epidemiological study of PD in the county of Rogaland, Norway, were assessed at baseline and 4 years later with neurological, psychiatric, and neuropsychological evaluations. Twenty-five (42%) new cases of dementia were diagnosed after 4 years. Time to complete the third card of the Stroop test was the only variable that was independently associated with dementia. The authors concluded that poor performance on a test sensitive to executive dysfunction predicted later development of dementia in PD patients. This finding may have important clinical implications as a marker of subsequent development of dementia.


Subject(s)
Cognition Disorders/epidemiology , Dementia/epidemiology , Parkinson Disease/epidemiology , Aged , Cognition Disorders/diagnosis , Dementia/diagnosis , Female , Follow-Up Studies , Humans , Male , Neuropsychological Tests , Predictive Value of Tests , Residence Characteristics
10.
Dement Geriatr Cogn Disord ; 15(3): 126-31, 2003.
Article in English | MEDLINE | ID: mdl-12584427

ABSTRACT

Cognitive deficits are often associated with Parkinson's disease (PD), although their prevalence in PD patients without dementia is still unknown. In order to describe the neuropsychological profile of PD patients without dementia, a sample of 103 PD patients was compared with a control group consisting of 38 healthy elderly subjects. Psychometric assessment consisted of the Mini Mental State Examination, the Dementia Rating Scale and a battery of neuropsychological tests. The Beck Depression Inventory was used to assess depression in PD patients. Dementia was diagnosed in 27 patients. Among non-demented subjects, 34 (45%) had no cognitive impairment and 42 (55%) had a mild cognitive impairment. Subjects with mild cognitive impairment were older, had a later onset of the disease, and more severe motor symptoms than cognitively intact subjects. Identification of mild cognitive impairment is important, since these symptoms are important for patient management and may also facilitate to determine prognosis.


Subject(s)
Cognition Disorders/diagnosis , Parkinson Disease/psychology , Aged , Case-Control Studies , Cognition Disorders/etiology , Dementia/complications , Dementia/diagnosis , Female , Humans , Male , Neuropsychological Tests , Parkinson Disease/complications , Psychometrics , Severity of Illness Index , Task Performance and Analysis
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