ABSTRACT
Review of the literature discloses 76 cases of carcinoma metastatic to the palatine tonsil. Of these cases reported or mentioned, 51 were detailed sufficiently or occurred frequently enough to allow analysis. We add two new cases of hypernephroma, and also study the courses of patients with primaries of the stomach, breast, lung and melanoma and seminoma. Bilateral tonsilar involvement is found to be very common in melanoma and not uncommon in seminoma and adenocarcinomas of the stomach and breast. It is uncommon for bronchogenic carcinoma and hypernephroma to metastasize to both palatine tonsils. When laterality is present the left tonsil is more commonly involved than the right, except by melanoma. Regarding neoplastic involvement of the primary organ, the left side gives rise to malignancies more often than the right side. Only seminoma has a high incidence of other metastases. The mean time interval between development of the primary and the tonsillar secondary is one year or less in seminomas, bronchogenic carcinomas and adenocarcinomas of the stomach, but 2 1/2 years or more for adenocarcinomas of the breast and kidney and melanomas. The mean time of survival after appearance of the tonsillar metastasis is nine months or less, regardless of the cell type of the primary malignancy.
Subject(s)
Adenocarcinoma/pathology , Tonsillar Neoplasms/pathology , Adenocarcinoma/physiopathology , Adult , Female , Humans , Kidney Neoplasms/pathology , Lung Neoplasms/pathology , Male , Middle Aged , Neoplasm Metastasis , Neoplasm Recurrence, Local , Tonsillar Neoplasms/physiopathologyABSTRACT
Hyperplasia induced by N-2-fluorenylacetamide requires the continuous presence of the chemical for its maintenance. Feeding the chemical at levels of 8 to 86 ppm results in a dose-response related urinary bladder hyperplasia and, after 9 to 12 months, in bladder neoplasia at the higher dose levels. Neoplasia of the lungs, liver, parotid gland, lacrimal gland, harderian gland, and submaxillary gland was also observed. Measurement of oncogenic viruses revealed no synergism with 2-FAA and no relationship between virus counts and neoplasia. Calcareous pericarditis was observed and most general toxicological effects occurred in the liver. A pronounced sex difference in response was observed with the males giving greater responses than the females in all instances.
