Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters











Database
Language
Publication year range
1.
Clin Transl Oncol ; 7(5): 205-12, 2005 Jun.
Article in Spanish | MEDLINE | ID: mdl-15960932

ABSTRACT

INTRODUCTION: Oral trans-mucosal fentanyl citrate (OTFC) is the one drug specifically developed for the management of breakthrough pain. This study assesses the long-term safety and efficacy of OTFC standard clinical conditions. Patients and methods. Six-month observational study performed on cancer patients with episodes of breakthrough pain. Safety was assessed by recording the advent of adverse events and efficacy by the evaluating the intensity of breakthrough pain. RESULTS: 174 cancer patients were recruited into the study. All adverse reactions reported were mild or moderate. OTFC was significantly faster (time to the commencement of pain relief: 12.7 +/- 11.4 vs 32.7 +/- 18.4 minutes; p < 0.001) and potent (post-treatment pain intensity: 3.4 +/- 1.5 vs 4.3 +/- 1.5; p < 0.001) than the previously-used drugs. CONCLUSIONS: This observational study confirms the good safety profile of OTFC as well as its effectiveness over long-term period treatment of breakthrough pain.


Subject(s)
Analgesics, Opioid/administration & dosage , Fentanyl/administration & dosage , Pain, Intractable/drug therapy , Administration, Oral , Adult , Aged , Aged, 80 and over , Analgesics, Opioid/adverse effects , Female , Fentanyl/adverse effects , Humans , Long-Term Care , Male , Middle Aged , Mouth Mucosa , Pain Measurement/methods , Safety , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL