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Bioorg Med Chem Lett
; 16(7): 1799-802, 2006 Apr 01.
Article
in English
| MEDLINE
| ID: mdl-16442794
ABSTRACT
Heptanoic acid lactams, exemplified by 2, were identified as highly selective EP4 agonists via high throughput screening. Lead optimization led to the identification of lactams with a 30-fold increase in EP4 potency in vitro. Compounds demonstrated robust bone anabolic effects when administered in vivo in rat models of osteoporosis.